Zong, Dali ; Jakob, Burkhard ; Lundholm, Lovisa (2023)
Editorial: DNA damage response in the context of chromatin.
In: Frontiers in Cell and Developmental Biology, 10
doi: 10.3389/fcell.2022.1095652
Artikel, Bibliographie

Grandt, Caine Lucas ; Brackmann, Lara Kim ; Poplawski, Alicia ; Schwarz, Heike ; Marini, Federico ; Hankeln, Thomas ; Galetzka, Danuta ; Zahnreich, Sebastian ; Mirsch, Johanna ; Spix, Claudia ; Blettner, Maria ; Schmidberger, Heinz ; Marron, Manuela (2023)
Identification of lncRNAs involved in response to ionizing radiation in fibroblasts of long-term survivors of childhood cancer and cancer-free controls.
In: Frontiers in Oncology, 13
doi: 10.3389/fonc.2023.1158176
Artikel, Bibliographie

Brackmann, Lara Kim ; Foraita, Ronja ; Schwarz, Heike ; Galetzka, Danuta ; Zahnreich, Sebastian ; Hankeln, Thomas ; Löbrich, Markus ; Poplawski, Alicia ; Grabow, Desiree ; Blettner, Maria ; Schmidberger, Heinz ; Marron, Manuela (2022)
Late health effects and changes in lifestyle factors after cancer in childhood with and without subsequent second primary cancers - the KiKme case-control study.
In: Frontiers in oncology, 12
doi: 10.3389/fonc.2022.1037276
Artikel, Bibliographie

Smit, Timo Eric (2022)
Kardiotoxizität weltraumrelevanter Schwerionenstrahlung: In vitro Effekte auf Funktion und Pathophysiologie von Kardiomyozyten.
Technische Universität Darmstadt
doi: 10.26083/tuprints-00020924
Dissertation, Erstveröffentlichung, Verlagsversion

Freund, Isabel (2022)
Nek1 - developmental involvement in DNA repair and role as a target in radiotherapy.
Technische Universität Darmstadt
doi: 10.26083/tuprints-00021560
Dissertation, Erstveröffentlichung, Verlagsversion

Wei, Na (2022)
RNA involvement during non-homologous end joining of resected DNA double strand breaks in G1.
Technische Universität Darmstadt
doi: 10.26083/tuprints-00021565
Dissertation, Erstveröffentlichung, Verlagsversion

Pfeffel, Daniel (2022)
Investigating the interplay of replication, transcription, and BER for the induction of DSBs after oxidative stress.
Technische Universität Darmstadt
doi: 10.26083/tuprints-00022399
Dissertation, Erstveröffentlichung, Verlagsversion

Thomas, Holly (2022)
Investigating the importance of RAD54 and NEK1 in homologous recombination within the developing mouse.
Technische Universität Darmstadt
doi: 10.26083/tuprints-00022952
Dissertation, Erstveröffentlichung, Verlagsversion

Goetting, Isabell ; Larafa, Safa ; Eul, Katharina ; Kunin, Mikhail ; Jakob, Burkhard ; Matschke, Johann ; Jendrossek, Verena (2022)
Targeting AKT-Dependent Regulation of Antioxidant Defense Sensitizes AKT-E17K Expressing Cancer Cells to Ionizing Radiation.
In: Frontiers in Oncology, 12
doi: 10.3389/fonc.2022.920017
Artikel, Bibliographie

Averbeck, Nicole B. ; Barent, Carina ; Jakob, Burkhard ; Syzonenko, Tatyana ; Durante, Marco ; Taucher-Scholz, Gisela (2022)
The Ubiquitin Ligase RNF138 Cooperates with CtIP to Stimulate Resection of Complex DNA Double-Strand Breaks in Human G1-Phase Cells.
In: Cells, 11 (16)
doi: 10.3390/cells11162561
Artikel, Bibliographie

Llorens-Agost, Marta ; Ensminger, Michael ; Le, Hang Phuong ; Gawai, Anugrah ; Liu, Jie ; Cruz-García, Andrés ; Bhetawal, Sarita ; Wood, Richard D. ; Heyer, Wolf-Dietrich ; Löbrich, Markus (2021)
Publisher Correction: POLθ-mediated end joining is restricted by RAD52 and BRCA2 until the onset of mitosis.
In: Nature cell biology
doi: 10.1038/s41556-021-00797-5
Artikel, Bibliographie

Llorens-Agost, Marta ; Ensminger, Michael ; Le, Hang Phuong ; Gawai, Anugrah ; Liu, Jie ; Cruz-García, Andrés ; Bhetawal, Sarita ; Wood, Richard D. ; Heyer, Wolf-Dietrich ; Löbrich, Markus (2021)
POLθ-mediated end joining is restricted by RAD52 and BRCA2 until the onset of mitosis.
In: Nature cell biology, 23 (10)
doi: 10.1038/s41556-021-00764-0
Artikel, Bibliographie

Elbakry, Amira ; Löbrich, Markus (2021)
Homologous Recombination Subpathways : a Tangle to Resolve.
In: Frontiers in genetics, 12
doi: 10.3389/fgene.2021.723847
Artikel, Bibliographie

Elbakry, Amira (2021)
Factors regulating late stages of homologous recombination and sub-pathway choice in G2.
Technische Universität Darmstadt
doi: 10.26083/tuprints-00017575
Dissertation, Erstveröffentlichung, Verlagsversion

Elbakry, Amira ; Juhász, Szilvia ; Chan, Ki Choi ; Löbrich, Markus (2021)
ATRX and RECQ5 define distinct homologous recombination subpathways.
In: Proceedings of the National Academy of Sciences of the United States of America, 118 (3)
doi: 10.1073/pnas.2010370118
Artikel, Bibliographie

Averbek, Sera (2021)
Effects of O-GlcNAcylation on radiation-induced DNA double-strand break repair.
Technische Universität Darmstadt
doi: 10.26083/tuprints-00020192
Dissertation, Erstveröffentlichung, Verlagsversion

Llorens-Agost, Marta ; Ensminger, Michael ; Le, Hang Phuong ; Heyer, Wolf-Dietrich ; Löbrich, Markus (2021)
Turning end-joining upside down in mitosis.
In: Molecular & cellular oncology, 8 (6)
doi: 10.1080/23723556.2021.2007029
Artikel, Bibliographie

Averbek, Sera ; Jakob, Burkhard ; Durante, Marco ; Averbeck, Nicole B. (2021)
O-GlcNAcylation affects the pathway choice of DNA double-strand break repair.
In: International Journal of Molecular Sciences, 22 (11)
doi: 10.3390/ijms22115715
Artikel, Bibliographie

Mirsch, Johanna ; Hintz, Lisa ; Maier, Andreas ; Fournier, Claudia ; Löbrich, Markus (2020)
An assessment of radiation doses from radon exposures using a mouse model system.
In: International journal of radiation oncology, biology, physics, 108 (3)
doi: 10.1016/j.ijrobp.2020.05.031
Artikel, Bibliographie

Brackmann, Lara Kim ; Poplawski, Alicia ; Grandt, Caine Lucas ; Schwarz, Heike ; Hankeln, Thomas ; Rapp, Steffen ; Zahnreich, Sebastian ; Galetzka, Danuta ; Schmitt, Iris ; Grad, Christian ; Eckhard, Lukas ; Mirsch, Johanna ; Blettner, Maria ; Scholz-Kreisel, Peter ; Hess, Moritz ; Binder, Harald ; Schmidberger, Heinz ; Marron, Manuela (2020)
Comparison of time and dose dependent gene expression and affected pathways in primary human fibroblasts after exposure to ionizing radiation.
In: Molecular Medicine, 26 (1)
doi: 10.1186/s10020-020-00203-0
Artikel, Bibliographie

Güllülü, Ömer (2020)
Spatial and functional interrelationship of a heterotetramer Survivin-DNA-PKcs complex in the repair of DNA double-strand breaks.
Technische Universität Darmstadt
doi: 10.25534/tuprints-00015406
Dissertation, Erstveröffentlichung, Verlagsversion

Zahnreich, Sebastian ; Poplawski, Alicia ; Hartel, Carola ; Eckhard, Lukas Stefan ; Galetzka, Danuta ; Hankeln, Thomas ; Löbrich, Markus ; Marron, Manuela ; Mirsch, Johanna ; Ritter, Sylvia ; Scholz-Kreisel, Peter ; Spix, Claudia ; Schmidberger, Heinz (2020)
Spontaneous and Radiation-Induced Chromosome Aberrations in Primary Fibroblasts of Patients With Pediatric First and Second Neoplasms.
In: Frontiers in oncology, 10
doi: 10.3389/fonc.2020.01338
Artikel, Bibliographie

Freund, Isabel ; Hehlgans, Stephanie ; Martin, Daniel ; Ensminger, Michael ; Fokas, Emmanouil ; Rödel, Claus ; Löbrich, Markus ; Rödel, Franz (2020)
Fractionation-Dependent Radiosensitization by Molecular Targeting of Nek1.
In: Cells, 9 (5)
doi: 10.3390/cells9051235
Artikel, Bibliographie

Frohns, Florian ; Frohns, Antonia ; Kramer, Johanna ; Meurer, Katharina ; Rohrer-Bley, Carla ; Solovei, Irina ; Hicks, David ; Layer, Paul G. ; Löbrich, Markus (2020)
Differences in the Response to DNA Double-Strand Breaks between Rod Photoreceptors of Rodents, Pigs, and Humans.
In: Cells, 9 (4)
doi: 10.3390/cells9040947
Artikel, Bibliographie

Barent, Carina (2020)
Relevanz der Ubiquitinierung für die Resektionsregulation in G1-Phase-Zellen an schwerioneninduzierten DNA-Doppelstrangbrüchen.
Technische Universität Darmstadt
doi: 10.25534/tuprints-00011439
Dissertation, Erstveröffentlichung

Ensminger, Michael ; Löbrich, Markus (2020)
One end to rule them all: Non-homologous end-joining and homologous recombination at DNA double-strand breaks.
In: The British journal of radiology, 93 (1115)
doi: 10.1259/bjr.20191054
Artikel, Bibliographie

Löbrich, Markus ; Jeggo, Penny A. (2019)
Hazards of human spaceflight.
In: Science (New York, N.Y.), 364 (6436)
doi: 10.1126/science.aaw7086
Artikel, Bibliographie

Köhler, Tim (2019)
Auswirkungen elektromagnetischer Strahlung auf die elektrophysiologischen Eigenschaften neuronaler und kardialer Zellnetzwerke.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Lengert, Nicor ; Mirsch, Johanna ; Weimer, Ratna N. ; Schumann, Eik ; Haub, Peter ; Drossel, Barbara ; Löbrich, Markus (2018)
AutoFoci, an automated high-throughput foci detection approach for analyzing low-dose DNA double-strand break repair.
In: Scientific reports, 8 (1)
Artikel, Bibliographie

Shibata, Atsushi ; Jeggo, Penny ; Löbrich, Markus (2018)
The pendulum of the Ku-Ku clock.
In: DNA repair, 71
Artikel, Bibliographie

Elbakry, Amira ; Juhász, Szilvia ; Mathes, Arthur ; Löbrich, Markus (2018)
DNA repair synthesis and histone deposition partner during homologous recombination.
In: Molecular & cellular oncology, 5 (5)
Artikel, Bibliographie

Juhász, Szilvia ; Elbakry, Amira ; Mathes, Arthur ; Löbrich, Markus (2018)
ATRX Promotes DNA Repair Synthesis and Sister Chromatid Exchange during Homologous Recombination.
In: Molecular cell, 71 (1)
Artikel, Bibliographie

Gawai, Anugrah (2018)
Characterization of Rad52 protein function during DNA double-strand break repair in G2 phase mammalian cells.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Syzonenko, Tatyana (2018)
Investigations to the DNA resection regulation of ion-induced DSBs in G1 cells and the resection limitations of the cells in quiescent state.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Abdollahi Mirzanagh, Elham ; Taucher-Scholz, Gisela ; Jakob, Burkhard (2018)
Application of Fluorescence Lifetime Imaging Microscopy of DNA Binding Dyes to Assess Radiation-Induced Chromatin Compaction Changes.
In: International Journal of Molecular Sciences, 19 (8)
doi: 10.3390/ijms19082399
Artikel, Bibliographie

Mofidi, Amir (2017)
DNA-double strand break repair and cell cycle control of murine stem cells after exposure to ionizing radiation.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Jeggo, Penny A. ; Löbrich, Markus (2017)
DNA non-homologous end-joining enters the resection arena.
In: Oncotarget, 8 (55)
Artikel, Bibliographie

Löbrich, Markus ; Jeggo, Penny (2017)
A Process of Resection-Dependent Nonhomologous End Joining Involving the Goddess Artemis.
In: Trends in biochemical sciences, 42 (9)
Artikel, Bibliographie

Essary, T. ; Oppermann, J. ; Weipert, F. ; Löbrich, Markus ; Roedel, C. ; Roedel, F. ; Hehlgans, S. (2017)
Modulation of the cellular Radiation Response in colorectal Cells after Inhibition of the DNA-Repair Factor Nek1.
In: Strahlentherapie und Onkologie, 193
Artikel, Bibliographie

Steinlage, Monika (2017)
Characterization of the slow DNA double-strand break repair component in G1 phase.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Biehs, Ronja ; Steinlage, Monika ; Barton, Olivia ; Juhász, Szilvia ; Künzel, Julia ; Spies, Julian ; Shibata, Atsushi ; Jeggo, Penny A. ; Löbrich, Markus (2017)
DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination.
In: Molecular cell, 65 (4)
Artikel, Bibliographie

Mirsch, Johanna (2017)
Biologischer Nachweis niedriger Dosen ionisierender Strahlung.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Shreder, Kateryna (2017)
Impact of ionizing radiation on adipokine-induced inflammation in musculoskeletal diseases (MSD): Investigations in primary cells and MSD patients.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Erbeldinger, Nadine (2017)
Microvascular Damage as Initial Event of Scar Formation after Carbon Ion Irradiation of Cardiac Substructures.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Mayer, Margot (2017)
Einfluss ionisierender Strahlung auf die elektrophysiologischen Eigenschaften sich entwickelnder neuronaler Netzwerke.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Anugwom (geb. Biehs), Ronja (2017)
Resection-dependent canonical non-homologous end-joining induces genomic rearrangements.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Waizenegger, Anja (2016)
Investigation of factors involved in late stages of homologous recombination.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Simoniello, Palma ; Wiedemann, Julia ; Zink, Joana ; Thoennes, Eva ; Stange, Maike ; Layer, Paul G. ; Kovacs, Maximilian ; Podda, Maurizio ; Durante, Marco ; Fournier, Claudia (2016)
Exposure to carbon ions triggers proinflammatory signals and changes in homeostasis and epidermal tissue organization to a similar extent as photons.
In: Frontiers in oncology, 5
doi: 10.3389/fonc.2015.00294
Artikel, Bibliographie

Wiedemann, Julia (2016)
Untersuchung von entzündungsrelevanter interzellulärer Kommunikation nach Bestrahlung in einem 3D-Haut-Modell.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Spies, Julian ; Waizenegger, Anja ; Barton, Olivia ; Sürder, Michael ; Wright, William D. ; Heyer, Wolf-Dietrich ; Löbrich, Markus (2016)
Nek1 Regulates Rad54 to Orchestrate Homologous Recombination and Replication Fork Stability.
In: Molecular cell, 62 (6)
Artikel, Bibliographie

Wess, Johannes (2016)
Untersuchungen zur Prozessierung von Intermediaten der DNA-Doppelstrangbruchreparatur in der Mitose nach Bestrahlung in der G2-Phase.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Large, Martin (2015)
Cellular and molecular aspects of the anti-inflammatory effects of low-dose radiation therapy.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Taubmann, Andreas (2015)
Untersuchung der DNA-Doppelstrangbruch-Reparatur über Homologe Rekombination am Übergang von der G2-Phase in die Mitose.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Maier, Andreas (2015)
Entwicklung einer Radonkammer und Messung der Radonlöslichkeit in Gewebe.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Lengert, Laurin (2015)
Theoretische und experimentelle Methoden zur Verbesserung der Unterscheidbarkeit alternativer Modelle der Proteinrekrutierung.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Spies, Julian (2015)
Die Beteiligung von Nek1 an der Homologen Rekombination.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Jeggo, Penny A. ; Löbrich, Markus (2015)
How cancer cells hijack DNA double-strand break repair pathways to gain genomic instability.
In: The Biochemical journal, 471 (1)
Artikel, Bibliographie

Mirsch, Johanna ; Tommasino, Francesco ; Frohns, Antonia ; Conrad, Sandro ; Durante, Marco ; Scholz, Michael ; Friedrich, Thomas ; Löbrich, Markus (2015)
Direct measurement of the 3-dimensional DNA lesion distribution induced by energetic charged particles in a mouse model tissue.
In: Proceedings of the National Academy of Sciences of the United States of America, 112 (40)
Artikel, Bibliographie

Knorr, Sabine (2014)
In Silico Strategies to Modulate DNA Damage Response.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Krasnyanska, Julia (2014)
DNA‐Doppelstrangbruchreparatur im DT40‐Zellsystem.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Petraki, Chrysi Eirini (2014)
The role of the inhibitor of apoptosis protein Survivin in cellular radiation response.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Becker, Linda Carmen Annabelle (2014)
Influence of repair proteins and chromatin modifiers on mobility of DNA double-strand breaks induced by heavy ion irradiation.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Reul, Christian (2014)
Mechanisms and factors determining DSB repair pathway choice in G2.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Frohns, Antonia ; Frohns, Florian ; Naumann, Steffen C. ; Layer, Paul G. ; Löbrich, Markus (2014)
Inefficient Double-Strand Break Repair in Murine Rod Photoreceptors with Inverted Heterochromatin Organization.
In: Current biology : CB, 24 (10)
Artikel, Bibliographie

Makharashvili, Nodar ; Tubbs, Anthony T. ; Yang, Soo-Hyun ; Wang, Hailong ; Barton, Olivia ; Zhou, Yi ; Deshpande, Rajashree A. ; Lee, Ji-Hoon ; Löbrich, Markus ; Sleckman, Barry P. ; Wu, Xiaohua ; Paull, Tanya T. (2014)
Catalytic and Noncatalytic Roles of the CtIP Endonuclease in Double-Strand Break End Resection.
In: Molecular cell, 54 (6)
Artikel, Bibliographie

Längle, Adriana (2014)
Ionotrope Glutamatrezeptoren als Targetstrukturen zur Modulation der Strahlenwirkung bei Glioblastomzellen.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Herrlitz, Maren Linda (2014)
Elucidation of DNA methylation changes in response to ionizing radiation induced double strand breaks.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Kakarougkas, Andreas ; Ismail, Amani ; Chambers, Anna L. ; Riballo, Enriqueta ; Herbert, Alex D. ; Künzel, Julia ; Löbrich, Markus ; Jeggo, Penny A. ; Downs, Jessica A. (2014)
Requirement for PBAF in Transcriptional Repression and Repair at DNA Breaks in Actively Transcribed Regions of Chromatin.
In: Molecular cell, 55 (5)
Artikel, Bibliographie

Iloff, Lucie (2014)
Untersuchungen zur Induktion und Reparatur von DNA-Schäden durch Hydroxyurea.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Ensminger, Michael ; Iloff, Lucie ; Ebel, Christian ; Nikolova, Teodora ; Kaina, Bernd ; Löbrich, Markus (2014)
DNA breaks and chromosomal aberrations arise when replication meets base excision repair.
In: The Journal of cell biology, 206 (1)
Artikel, Bibliographie

Barton, Olivia ; Naumann, Steffen C. ; Diemer-Biehs, Ronja ; Künzel, Julia ; Steinlage, Monika ; Conrad, Sandro ; Makharashvili, Nodar ; Wang, Jiadong ; Feng, Lin ; Lopez, Bernard S. ; Paull, Tanya T. ; Chen, Junjie ; Jeggo, Penny A. ; Löbrich, Markus (2014)
Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1.
In: The Journal of cell biology, 206 (7)
Artikel, Bibliographie

Wang, Jiadong ; Aroumougame, Asaithamby ; Löbrich, Markus ; Li, Yujing ; Chen, David ; Chen, Junjie ; Gong, Zihua (2014)
PTIP associates with Artemis to dictate DNA repair pathway choice.
In: Genes & development, 28 (24)
Artikel, Bibliographie

Roth, Bastian (2013)
Exposure to sparsely and densely ionizing irradiation results in an immediate activation of K+ channels in A549 cells and in human peripheral blood lymphocytes.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Frohns, Antonia (2013)
Untersuchung der DNA-Schadensantwort in der murinen Retina nach ionisierender Strahlung.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Ebel, Christian (2013)
Studien zur Reparatur Camptothecin- und Methylmethansulfonat-induzierter DNA-Schäden.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Dettmering, Till (2013)
Effects of carbon ion irradiation on inflammatory processes and normal tissue damage in the endothelium and the rat lung.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Helm, Alexander (2013)
Influence of High- and Low-LET Radiation on the Cardiac Differentiation of Mouse Embryonic Stem Cells.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Singh, Mayank ; Hunt, Clayton R. ; Pandita, Raj K. ; Kumar, Rakesh ; Yang, Chin-Rang ; Horikoshi, Nobuo ; Bachoo, Robert ; Serag, Sara ; Story, Michael D. ; Shay, Jerry W. ; Powell, Simon N. ; Gupta, Arun ; Jeffery, Jessie ; Pandita, Shruti ; Chen, Benjamin P. C. ; Deckbar, Dorothee ; Löbrich, Markus ; Yang, Qin ; Khanna, Kum Kum ; Worman, Howard J. ; Pandita, Tej K. (2013)
Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest.
In: Molecular and cellular biology, 33 (6)
Artikel, Bibliographie

Beuke, Marcus (2013)
Untersuchung zur Relokalisierung heterochromatischer DNA Läsionen.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Geuting, Verena ; Reul, Christian ; Löbrich, Markus (2013)
ATM Release at Resected Double-Strand Breaks Provides Heterochromatin Reconstitution to Facilitate Homologous Recombination.
In: PLoS genetics, 9 (8)
Artikel, Bibliographie

Kakarougkas, Andreas ; Ismail, Amani ; Klement, Karolin ; Goodarzi, Aaron A. ; Conrad, Sandro ; Freire, Raimundo ; Shibata, Atsushi ; Löbrich, Markus ; Jeggo, Penny A. (2013)
Opposing roles for 53BP1 during homologous recombination.
In: Nucleic acids research, 41 (21)
Artikel, Bibliographie

Fischer, Ulrike ; Rheinheimer, Stefanie ; Krempler, Andrea ; Löbrich, Markus ; Meese, Eckart (2013)
Glioma-amplified sequence KUB3 influences double-strand break repair after ionizing radiation.
In: International journal of oncology, 43 (1)
Artikel, Bibliographie

Reichert, Sebastian (2012)
Der Apoptoseinhibitor Survivin als molekulare Zielstruktur einer Modulation der intrinsischen Strahlenresistenz von Tumorzellen.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Brand, Michael ; Sommer, Matthias ; Achenbach, Stephan ; Anders, Katharina ; Lell, Michael ; Löbrich, Markus ; Uder, Michael ; Kuefner, Michael A. (2012)
X-ray induced DNA double-strand breaks in coronary CT angiography: Comparison of sequential, low-pitch helical and high-pitch helical data acquisition.
In: European journal of radiology, 81 (3)
Artikel, Bibliographie

Löbrich, Markus (2012)
Double strand break repair and checkpoint control after low radiation doses [Abstracts of the 34th Annual Meeting of the United Kingdom Environmental Mutagen Society, 29th June – 1st July 2011].
In: Mutagenesis, 27 (1)
Artikel, Bibliographie

Ensminger, Michael (2011)
Untersuchungen zur Reparatur Methylmethansulfonat-induzierter DNA-Schäden.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Conrad, Sandro ; Künzel, Julia ; Löbrich, Markus (2011)
Sister chromatid exchanges occur in G2-irradiated cells.
In: Cell cycle (Georgetown, Tex.), 10 (2)
Artikel, Bibliographie

Shibata, Atsushi ; Conrad, Sandro ; Birraux, Julie ; Geuting, Verena ; Barton, Olivia ; Ismail, Amani ; Kakarougkas, Andreas ; Meek, Katheryn ; Taucher-Scholz, Gisela ; Löbrich, Markus ; Jeggo, Penny A. (2011)
Factors determining DNA double-strand break repair pathway choice in G2 phase.
In: The EMBO journal
Artikel, Bibliographie

Jakob, Burkhard ; Splinter, Jörn ; Conrad, Sandro ; Voss, Kay-Obbe ; Zink, Daniele ; Durante, Marco ; Löbrich, Markus ; Taucher-Scholz, Gisela (2011)
DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin.
In: Nucleic acids research, 39 (15)
Artikel, Bibliographie

Deckbar, Dorothee ; Jeggo, Penny A. ; Löbrich, Markus (2011)
Understanding the limitations of radiation-induced cell cycle checkpoints.
In: Critical reviews in biochemistry and molecular biology, 46 (4)
Artikel, Bibliographie

Beucher, Andrea ; Deckbar, Dorothee ; Schumann, Eik ; Krempler, Andrea ; Frankenberg-Schwager, Marlis ; Löbrich, Markus (2011)
Elevated radiation-induced γH2AX foci in G2 phase heterozygous BRCA2 fibroblasts.
In: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 101 (1)
Artikel, Bibliographie

Jeggo, Penny A. ; Geuting, Verena ; Löbrich, Markus (2011)
The role of homologous recombination in radiation-induced double-strand break repair.
In: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 101 (1)
Artikel, Bibliographie

Quennet, Verena ; Beucher, Andrea ; Barton, Olivia ; Takeda, Shunichi ; Löbrich, Markus (2011)
CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1.
In: Nucleic acids research, 39 (6)
Artikel, Bibliographie

Splinter, Jörn (2010)
Distribution and dynamics of charged particle-induced DNA double-strand breaks.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Barton, Olivia (2010)
Checkpointkontrolle und Reparatur Heterochromatin-assoziierter DNA-Doppelstrangbrüche in bestrahlten G2-Phase Zellen.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Noon, Angela T. ; Shibata, A. ; Rief, N. ; Löbrich, M. ; Stewart, G. S. ; Jeggo, P. A. ; Goodarzi, A. A. (2010)
53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair.
In: Nature Cell Biology, 12 (2)
Artikel, Bibliographie

Löbrich, Markus ; Shibata, Atsushi ; Beucher, Andrea ; Fisher, Anna ; Ensminger, Michael ; Goodarzi, Aaron A. ; Barton, Olivia ; Jeggo, Penny A. (2010)
gammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization.
In: Cell cycle (Georgetown, Tex.), 9 (4)
Artikel, Bibliographie

Kuefner, Michael A. ; Hinkmann, Fabian M. ; Alibek, Sedat ; Azoulay, Sascha ; Anders, Katharina ; Kalender, Willi A. ; Achenbach, Stephan ; Grudzenski, Saskia ; Löbrich, Markus ; Uder, Michael (2010)
Reduction of X-ray induced DNA double-strand breaks in blood lymphocytes during coronary CT angiography using high-pitch spiral data acquisition with prospective ECG-triggering.
In: Investigative radiology, 45 (4)
Artikel, Bibliographie

Shibata, Atsushi ; Barton, Olivia ; Noon, Angela T. ; Dahm, Kirsten ; Deckbar, Dorothee ; Goodarzi, Aaron A. ; Löbrich, Markus ; Jeggo, Penny A. (2010)
Role of ATM and the damage response mediator proteins 53BP1 and MDC1 in the maintenance of G(2)/M checkpoint arrest.
In: Molecular and cellular biology, 30 (13)
Artikel, Bibliographie

Deckbar, Dorothee ; Stiff, Thomas ; Koch, Barbara ; Reis, Caroline ; Löbrich, Markus ; Jeggo, Penny A. (2010)
The limitations of the G1-S checkpoint.
In: Cancer research, 70 (11)
Artikel, Bibliographie

Kuefner, M. A. ; Grudzenski, S. ; Hamann, J. ; Achenbach, S. ; Lell, Michael ; Anderson, K. ; Schwab, S. A. ; Häberle, L. ; Löbrich, M. ; Uder, M. (2010)
Effect of CT scan protocols on x-ray-induced DNA double-strand breaks in blood lymphocytes of patients undergoing coronary CT angiography.
In: European radiology
Artikel, Bibliographie

Grudzenski, Saskia ; Raths, Antonia ; Conrad, Sandro ; Rübe, Claudia E. ; Löbrich, Markus (2010)
Inducible response required for repair of low-dose radiation damage in human fibroblasts.
In: Proceedings of the National Academy of Sciences of the United States of America, 107 (32)
Artikel, Bibliographie

Nikolova, Teodora ; Ensminger, Michael ; Löbrich, Markus ; Kaina, Bernd (2010)
Homologous recombination protects mammalian cells from replication-associated DNA double-strand breaks arising in response to methyl methanesulfonate.
In: DNA repair, 9 (10)
Artikel, Bibliographie

Goodarzi, Aaron A. ; Jeggo, Penny ; Löbrich, Markus (2010)
The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax.
In: DNA repair, 9 (12)
Artikel, Bibliographie

Grudzenski, Saskia (2009)
Einfluss von Kontrastmittel und der applizierten Röntgendosis auf die Induktion und Reparatur von DNA-Doppelstrangbrüchen.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Beucher, Andrea (2009)
Untersuchungen zur Reparatur von DNA-Doppelstrangbrüchen in der G2-Phase des Zellzyklus.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Grudzenski, S. ; Küfner, M. A. ; Heckmann, M. B. ; Uder, M. ; Löbrich, M. (2009)
Contrast Medium-enhanced Radiation Damage Caused by CT Examinations.
In: Radiology
Artikel, Bibliographie

Küfner, M. A. ; Grudzenski, S. ; Schwab, S. A. ; Wiederseiner, M. ; Heckmann, M. ; Bautz, W. ; Löbrich, M. ; Uder, M. (2009)
DNA double-strand breaks and their repair in blood lymphocytes of patients undergoing angiographic procedures.
In: Investigative Radiology, 44 (8)
Artikel, Bibliographie

Küfner, M. A. ; Grudzenski, S. ; Schwab, S. A. ; Azoulay, S. ; Heckmann, M. ; Heinrich, M. C. ; Löbrich, M. ; Uder, M. (2009)
X-ray-induced DNA double-strand breaks after angiographic examinations of different anatomic regions.
In: Rofo, 181 (4)
Artikel, Bibliographie

Rübe, C. E. ; Grudzenski, S. ; Kühne, M. ; Dong, X. ; Rief, N. ; Löbrich, M. ; Rübe, C. (2008)
DNA double-strand break repair of blood lymphocytes and normal tissues analysed in a preclinical mouse model: implications for radiosensitivity testing.
In: Clinical Cancer Research, 14 (20)
Artikel, Bibliographie

Goodarzi, A. A. ; Noon, A. ; Deckbar, D. ; Ziv, Y. ; Shiloh, Y. ; Löbrich, M. ; Jeggo, P. A. (2008)
ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin.
In: Molecular Cell, 31 (2)
Artikel, Bibliographie

Toulany, M. ; Kehlbach, R. ; Florczak, U. ; Sak, A. ; Wang, S. ; Chen, J. ; Löbrich, M. ; Rodemann, H. P. (2008)
Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair.
In: Molecular Cancer Therapeutics, 7 (7)
Artikel, Bibliographie

Rothkamm, K. ; Gunasekara, K. ; Warda, S. ; Krempler, A. ; Löbrich, M. (2008)
Radiation-induced HPRT mutations resulting from misrejoined DNA double-strand breaks.
In: Radiation Research, 169 (6)
Artikel, Bibliographie

Seifert, M. ; Scherer, S. J. ; Edelmann, W. ; Böhm, M. ; Meineke, V. ; Löbrich, M. ; Tilgen, W. ; Reichrath, J. (2008)
The DNA-mismatch repair enzyme hMSH2 modulates UV-B-induced cell cycle arrest and apoptosis in melanoma cells.
In: Journal of Investigative Dermatology, 128 (1)
Artikel, Bibliographie

Jeggo, P. A. ; Löbrich, M. (2007)
DNA double-strand breaks: their cellular and clinical impact?
In: Oncogene, 26 (56)
Artikel, Bibliographie

Löbrich, M. ; Jeggo, P. A. (2007)
The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.
In: Nature Reviews Cancer, 7 (11)
Artikel, Bibliographie

Kegel, P. ; Riballo, E. ; Kühne, M. ; Jeggo, P. A. ; Löbrich, M. (2007)
X-irradiation of cells on glass slides has a dose doubling impact.
In: DNA Repair, 6 (11)
Artikel, Bibliographie

Krempler, A. ; Deckbar, D. ; Jeggo, P. A. ; Löbrich, M. (2007)
An imperfect G2M checkpoint contributes to chromosome instability following irradiation of S and G2 phase cells.
In: Cell Cycle, 6 (14)
Artikel, Bibliographie

Hunt, C. R. ; Pandita, R. K. ; Laszlo, A. ; Higashikubo, R. ; Agarwal, M. ; Kitamura, T. ; Gupta, A. ; Rief, N. ; Horikoshi, N. ; Baskaran, R. ; Lee, J. H. ; Löbrich, M. ; Paull, T. T. ; Roti Roti, J. L. ; Pandita, T. K. (2007)
Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status.
In: Cancer Research, 67 (7)
Artikel, Bibliographie

Deckbar, D. ; Birraux, J. ; Krempler, A. ; Tchouandong, L. ; Beucher, A. ; Walker, S. ; Stiff, T. ; Jeggo, P. A. ; Löbrich, M. (2007)
Chromosome breakage after G2 checkpoint release.
In: Journal of Cell Biology, 176 (6)
Artikel, Bibliographie

Chen, B. P. ; Uematsu, N. ; Kobayashi, J. ; Lerenthal, Y. ; Krempler, A. ; Yajima, H. ; Löbrich, M. ; Shiloh, Y. ; Chen, D. J. (2007)
Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.
In: Journal of Biological Chemistry, 282 (9)
Artikel, Bibliographie

Jeggo, P. A. ; Löbrich, M. (2006)
Contribution of DNA repair and cell cycle checkpoint arrest to the maintenance of genomic stability.
In: DNA Repair, 5 (9-10)
Artikel, Bibliographie

Löbrich, M. ; Kiefer, J. (2006)
Assessing the likelihood of severe side effects in radiotherapy.
In: International Journal of Cancer, 118 (11)
Artikel, Bibliographie

Jeggo, P. A. ; Löbrich, M. (2006)
Radiation-induced DNA damage responses.
In: Radiation Protection Dosimetry, 122 (1-4)
Artikel, Bibliographie

Kühne, M. ; Urban, G. ; Frankenberg, D. ; Löbrich, M. (2005)
DNA double-strand break misrejoining after exposure of primary human fibroblasts to CK characteristic X rays, 29 kVp X rays and 60Co gamma rays.
In: Radiation Research, 164 (5)
Artikel, Bibliographie

Löbrich, M. ; Jeggo, P. A. (2005)
The two edges of the ATM sword: co-operation between repair and checkpoint functions.
In: Radiotherapy and Oncology, 76 (2)
Artikel, Bibliographie

Löbrich, M. ; Jeggo, P. A. (2005)
Harmonising the response to DSBs: a new string in the ATM bow.
In: DNA Repair, 4 (7)
Artikel, Bibliographie

Löbrich, M. ; Rief, N. ; Kühne, M. ; Heckmann, M. ; Fleckenstein, J. ; Rübe, C. ; Uder, M. (2005)
In vivo formation and repair of DNA double-strand breaks after computed tomography examinations.
In: Proceedings of the National Academy of Sciences USA, 102 (25)
Artikel, Bibliographie

Jeggo, P. A. ; Löbrich, M. (2005)
Artemis links ATM to double strand break rejoining.
In: Cell Cycle, 4 (3)
Artikel, Bibliographie

Riballo, E. ; Kühne, M. ; Rief, N. ; Doherty, A. ; Smith, G. C. M. ; Recio, M. J. ; Reis, C. ; Dahm, K. ; Fricke, A. ; Krempler, A. ; Parker, A. R. ; Jackson, S. P. ; Gennery, A. ; Jeggo, P. A. ; Löbrich, M. (2004)
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.
In: Molecular Cell, 16 (5)
Artikel, Bibliographie

Stiff, T. ; O'Driscoll, M. ; Rief, N. ; Iwabuchi, K. ; Löbrich, M. ; Jeggo, P. A. (2004)
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation.
In: Cancer Research, 64 (7)
Artikel, Bibliographie

Kühne, M. ; Riballo, E. ; Rief, N. ; Rothkamm, K. ; Jeggo, P. A. ; Löbrich, M. (2004)
A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity.
In: Cancer Research, 64 (2)
Artikel, Bibliographie

Krüger, I. ; Rothkamm, K. ; Löbrich, M. (2004)
Enhanced fidelity for rejoining radiation-induced DNA double-strand breaks in the G2 phase of Chinese hamster ovary cells.
In: Nucleic Acids Research, 32 (9)
Artikel, Bibliographie

Rothkamm, K. ; Krüger, I. ; Thompson, L. H. ; Löbrich, M. (2003)
Pathways of DNA double-strand break repair during the mammalian cell cycle.
In: Molecular Cell Biology, 23 (16)
Artikel, Bibliographie

Rothkamm, K. ; Löbrich, M. (2003)
Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses.
In: Proceedings of the National Academy of Sciences USA, 100 (9)
Artikel, Bibliographie

Rothkamm, K. ; Löbrich, M. (2002)
Misrepair of radiation-induced DNA double-strand breaks and its relevance for tumorigenesis and cancer treatment (review).
In: International Journal of Oncology, 21 (2)
Artikel, Bibliographie

Rydberg, B. ; Heilbronn, L. ; Holley, W. R. ; Löbrich, M. ; Zeitlin, C. ; Chatterjee, A. ; Cooper, P. K. (2002)
Spatial distribution and yield of DNA double-strand breaks induced by 3-7 MeV helium ions in human fibroblasts.
In: Radiation Research, 158 (1)
Artikel, Bibliographie

Rief, N. ; Löbrich, M. (2002)
Efficient rejoining of radiation-induced DNA double-strand breaks in centromeric DNA of human cells.
In: Journal of Biological Chemistry, 277 (23)
Artikel, Bibliographie

Kühne, M. ; Rothkamm, K. ; Löbrich, M. (2002)
Physical and biological parameters affecting DNA double strand break misrejoining in mammalian cells.
In: Radiation Protection Dosimetry, 99 (1-4)
Artikel, Bibliographie

Tabocchini, M. A. ; Belli, M. ; Campa, A. ; Löbrich, M. ; Sapora, O. ; Simone, G. ; Stenerlow, B. (2002)
Induction and repair of DNA damage in human cells at different stages of differentiation.
In: Radiation Protection Dosimetry, 99 (1-4)
Artikel, Bibliographie

Rothkamm, K. ; Kühne, M. ; Jeggo, P. A. ; Löbrich, M. (2001)
Radiation-induced genomic rearrangements formed by nonhomologous end-joining of DNA double-strand breaks.
In: Cancer Research, 61 (10)
Artikel, Bibliographie

Tabocchini, M. A. ; Rothkamm, K. ; Signoretti, C. ; Risse, J. ; Sapora, O. ; Löbrich, M. (2000)
Formation and repair of DNA double-strand breaks in gamma-irradiated K562 cells undergoing erythroid differentiation.
In: Mutation Research, 461 (1)
Artikel, Bibliographie

Kühne, M. ; Rothkamm, K. ; Löbrich, M. (2000)
No dose-dependence of DNA double-strand break misrejoining following alpha-particle irradiation.
In: International Journal of Radiation Biology, 76 (7)
Artikel, Bibliographie

Löbrich, M. ; Kühne, M. ; Wetzel, J. ; Rothkamm, K. (2000)
Joining of correct and incorrect DNA double-strand break ends in normal human and ataxia telangiectasia fibroblasts.
In: Genes Chromosomes Cancer, 27 (1)
Artikel, Bibliographie

Rothkamm, K. ; Löbrich, M. (1999)
Misrejoining of DNA double-strand breaks in primary and transformed human and rodent cells: a comparison between the HPRT region and other genomic locations.
In: Mutation Research, 433 (3)
Artikel, Bibliographie

Löbrich, M. ; Cooper, P. K. ; Rydberg, B. (1998)
Joining of correct and incorrect DNA ends at double-strand breaks produced by high-linear energy transfer radiation in human fibroblasts.
In: Radiation Research, 150 (6)
Artikel, Bibliographie

Prise, K. M. ; Ahnstrom, G. ; Belli, M. ; Carlsson, J. ; Frankenberg, D. ; Kiefer, J. ; Löbrich, M. ; Michael, B. D. ; Nygren, J. ; Simone, G. ; Stenerlow, B. (1998)
A review of dsb induction data for varying quality radiations.
In: International Journal of Radiation Biology, 74 (2)
Artikel, Bibliographie

Rydberg, B. ; Löbrich, M. ; Cooper, P. K. (1998)
Repair of clustered DNA damage caused by high LET radiation in human fibroblasts.
In: Physica medica, Supplement, 14 (1)
Artikel, Bibliographie

Löbrich, M. (1998)
Induction and repair of DNA double-strand breaks in human fibroblasts after particle irradiation.
In: Advances in Space Research, 22 (4)
Artikel, Bibliographie

Löbrich, M. ; Cooper, P. K. ; Rydberg, B. (1996)
Non-random distribution of DNA double-strand breaks induced by particle irradiation.
In: International Journal of Radiation Biology, 70 (5)
Artikel, Bibliographie

Löbrich, M. ; Rydberg, B. ; Cooper, P. K. (1996)
Random-breakage mapping method applied to human DNA sequences.
In: Nucleic Acids Research, 24 (10)
Artikel, Bibliographie

Löbrich, M. ; Rydberg, B. ; Cooper, P. K. (1995)
Repair of x-ray-induced DNA double-strand breaks in specific Not I restriction fragments in human fibroblasts: joining of correct and incorrect ends.
In: Proceedings of the National Academy of Sciences USA, 92 (26)
Artikel, Bibliographie

Ikpeme, S. ; Löbrich, M. ; Akpa, T. ; Schneider, E. ; Kiefer, J. (1995)
Heavy ion-induced DNA double-strand breaks with yeast as a model system.
In: Radiation and Environmental Biophysics, 34 (2)
Artikel, Bibliographie

Löbrich, M. ; Rydberg, B. ; Cooper, P. K. (1994)
DNA double-strand breaks induced by high-energy neon and iron ions in human fibroblasts. II. Probing individual notI fragments by hybridization.
In: Radiation Research, 139 (2)
Artikel, Bibliographie

Rydberg, B. ; Löbrich, M. ; Cooper, P. K. (1994)
DNA double-strand breaks induced by high-energy neon and iron ions in human fibroblasts. I. Pulsed-field gel electrophoresis method.
In: Radiation Research, 139 (2)
Artikel, Bibliographie

Löbrich, M. ; Ikpeme, S. ; Kiefer, J. (1994)
DNA double-strand break measurement in mammalian cells by pulsed-field gel electrophoresis: an approach using restriction enzymes and gene probing.
In: International Journal of Radiation Biology, 65 (6)
Artikel, Bibliographie

Löbrich, M. ; Ikpeme, S. ; Kiefer, J. (1994)
Measurement of DNA double-strand breaks in mammalian cells by pulsed-field gel electrophoresis: a new approach using rarely cutting restriction enzymes.
In: Radiation Research, 138 (2)
Artikel, Bibliographie

Löbrich, M. ; Ikpeme, S. ; Haub, P. ; Weber, K. J. ; Kiefer, J. (1993)
DNA double-strand break induction in yeast by X-rays and alpha-particles measured by pulsed-field gel electrophoresis.
In: International Journal of Radiation Biology, 64 (5)
Artikel, Bibliographie

Löbrich, M. ; Ikpeme, S. ; Kiefer, J. (1993)
Analysis of the inversion effect in pulsed field gel electrophoresis by a two-dimensional contour-clamped homogeneous electric field system.
In: Analytical Biochemistry, 208 (1)
Artikel, Bibliographie