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A Process of Resection-Dependent Nonhomologous End Joining Involving the Goddess Artemis.

Löbrich, Markus and Jeggo, Penny :
A Process of Resection-Dependent Nonhomologous End Joining Involving the Goddess Artemis.
In: Trends in biochemical sciences, 42 (9) pp. 690-701. ISSN 0968-0004
[Article] , (2017)

Abstract

DNA double-strand breaks (DSBs) are a hazardous form of damage that can potentially cause cell death or genomic rearrangements. In mammalian G1- and G2-phase cells, DSBs are repaired with two-component kinetics. In both phases, a fast process uses canonical nonhomologous end joining (c-NHEJ) to repair the majority of DSBs. In G2, slow repair occurs by homologous recombination. The slow repair process in G1 also involves c-NHEJ proteins but additionally requires the nuclease Artemis and DNA end resection. Here, we consider the nature of slow DSB repair in G1 and evaluate factors determining whether DSBs are repaired with fast or slow kinetics. We consider limitations in our current knowledge and present a speculative model for Artemis-dependent c-NHEJ and the environment underlying its usage.

Item Type: Article
Erschienen: 2017
Creators: Löbrich, Markus and Jeggo, Penny
Title: A Process of Resection-Dependent Nonhomologous End Joining Involving the Goddess Artemis.
Language: English
Abstract:

DNA double-strand breaks (DSBs) are a hazardous form of damage that can potentially cause cell death or genomic rearrangements. In mammalian G1- and G2-phase cells, DSBs are repaired with two-component kinetics. In both phases, a fast process uses canonical nonhomologous end joining (c-NHEJ) to repair the majority of DSBs. In G2, slow repair occurs by homologous recombination. The slow repair process in G1 also involves c-NHEJ proteins but additionally requires the nuclease Artemis and DNA end resection. Here, we consider the nature of slow DSB repair in G1 and evaluate factors determining whether DSBs are repaired with fast or slow kinetics. We consider limitations in our current knowledge and present a speculative model for Artemis-dependent c-NHEJ and the environment underlying its usage.

Journal or Publication Title: Trends in biochemical sciences
Volume: 42
Number: 9
Divisions: 10 Department of Biology
10 Department of Biology > Radiation Biology and DNA Repair
Date Deposited: 29 Aug 2017 06:11
Identification Number: pmid:28739276
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