TU Darmstadt / ULB / TUbiblio

An assessment of radiation doses from radon exposures using a mouse model system.

Mirsch, Johanna ; Hintz, Lisa ; Maier, Andreas ; Fournier, Claudia ; Löbrich, Markus (2020)
An assessment of radiation doses from radon exposures using a mouse model system.
In: International journal of radiation oncology, biology, physics, 108 (3)
doi: 10.1016/j.ijrobp.2020.05.031
Artikel, Bibliographie

Kurzbeschreibung (Abstract)

BACKGROUND

Radon and its progenies contribute significantly to the natural background radiation and cause several thousands of lung cancer cases per year worldwide. Moreover, patients with chronic inflammatory joint diseases are treated in radon galleries. Due to the complex nature of radon exposure, the doses associated with radon exposures are difficult to assess. Hence, there is a clear need to directly measure dose depositions from radon exposures to provide reliable risk estimates for radiation protection guidelines.

OBJECTIVES

We aimed to assess tissue-specific radiation doses associated with radon activity concentrations which deposit similar dose levels as the annual natural radon exposure or radon gallery visits.

METHODS

We exposed mice to defined radon concentrations, quantified the number of 53BP1 foci as a measure of induced DNA damage and compared it with the number of foci induced by known doses of reference-type radiations. An image-based analysis of the 3-dimensional foci pattern provided information about the radiation type inflicting the DNA damage.

RESULTS

A 1-h exposure to 440 kBq/m radon induced DNA damage corresponding to a dose of ∼10 mGy in the lung and ∼3.3 mGy in the kidney, the heart and the liver. A 1-h exposure to 44 kBq/m provided values consistent with a linear relationship between dose and radon concentration. Two-thirds of the dose in the lung was caused by α-particles. The dose in the kidney, heart and liver and one-third of the dose in the lung likely resulted from β- and γ-rays.

DISCUSSION

We found that radon exposures mainly lead to α-particle-induced DNA damage in the lung, consistent with the lung cancer risk obtained in epidemiological studies. Our presented biodosimetric approach can be used to benchmark risk model calculations for radiation protection guidelines and can help to understand the therapeutic success of radon gallery treatments.

Typ des Eintrags: Artikel
Erschienen: 2020
Autor(en): Mirsch, Johanna ; Hintz, Lisa ; Maier, Andreas ; Fournier, Claudia ; Löbrich, Markus
Art des Eintrags: Bibliographie
Titel: An assessment of radiation doses from radon exposures using a mouse model system.
Sprache: Englisch
Publikationsjahr: November 2020
Titel der Zeitschrift, Zeitung oder Schriftenreihe: International journal of radiation oncology, biology, physics
Jahrgang/Volume einer Zeitschrift: 108
(Heft-)Nummer: 3
DOI: 10.1016/j.ijrobp.2020.05.031
Kurzbeschreibung (Abstract):

BACKGROUND

Radon and its progenies contribute significantly to the natural background radiation and cause several thousands of lung cancer cases per year worldwide. Moreover, patients with chronic inflammatory joint diseases are treated in radon galleries. Due to the complex nature of radon exposure, the doses associated with radon exposures are difficult to assess. Hence, there is a clear need to directly measure dose depositions from radon exposures to provide reliable risk estimates for radiation protection guidelines.

OBJECTIVES

We aimed to assess tissue-specific radiation doses associated with radon activity concentrations which deposit similar dose levels as the annual natural radon exposure or radon gallery visits.

METHODS

We exposed mice to defined radon concentrations, quantified the number of 53BP1 foci as a measure of induced DNA damage and compared it with the number of foci induced by known doses of reference-type radiations. An image-based analysis of the 3-dimensional foci pattern provided information about the radiation type inflicting the DNA damage.

RESULTS

A 1-h exposure to 440 kBq/m radon induced DNA damage corresponding to a dose of ∼10 mGy in the lung and ∼3.3 mGy in the kidney, the heart and the liver. A 1-h exposure to 44 kBq/m provided values consistent with a linear relationship between dose and radon concentration. Two-thirds of the dose in the lung was caused by α-particles. The dose in the kidney, heart and liver and one-third of the dose in the lung likely resulted from β- and γ-rays.

DISCUSSION

We found that radon exposures mainly lead to α-particle-induced DNA damage in the lung, consistent with the lung cancer risk obtained in epidemiological studies. Our presented biodosimetric approach can be used to benchmark risk model calculations for radiation protection guidelines and can help to understand the therapeutic success of radon gallery treatments.

ID-Nummer: pmid:32473181
Fachbereich(e)/-gebiet(e): 10 Fachbereich Biologie
10 Fachbereich Biologie > Radiation Biology and DNA Repair
Hinterlegungsdatum: 02 Jun 2020 11:50
Letzte Änderung: 20 Apr 2021 06:31
PPN:
Export:
Suche nach Titel in: TUfind oder in Google
Frage zum Eintrag Frage zum Eintrag

Optionen (nur für Redakteure)
Redaktionelle Details anzeigen Redaktionelle Details anzeigen