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Number of items: 56.

Noon, Angela T. and Shibata, A. and Rief, N. and Löbrich, M. and Stewart, G. S. and Jeggo, P. A. and Goodarzi, A. A. :
53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/20081839?itool=EntrezSyst...]
In: Nature Cell Biology, 12 (2) pp. 177-184.
[Article] , (2010)

Kuefner, M. A. and Grudzenski, S. and Hamann, J. and Achenbach, S. and Lell, Michael and Anderson, K. and Schwab, S. A. and Häberle, L. and Löbrich, M. and Uder, M. :
Effect of CT scan protocols on x-ray-induced DNA double-strand breaks in blood lymphocytes of patients undergoing coronary CT angiography.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/20625737]
In: European radiology ISSN 1432-1084
[Article] , (2010)

Beucher, A. and Birraux, J. and Tchouandong, L. and Barton, O. and Shibata, A. and Conrad, S. and Goodarzi, A. A. and Krempler, A. and Jeggo, P. A. and Löbrich, M. :
ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/19779458?itool=EntrezSyst...]
In: EMBO Journal, 28 (21) pp. 3413-3427.
[Article] , (2009)

Grudzenski, S. and Küfner, M. A. and Heckmann, M. B. and Uder, M. and Löbrich, M. :
Contrast Medium-enhanced Radiation Damage Caused by CT Examinations.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/19789225?dopt=Citation]
In: Radiology
[Article] , (2009)

Küfner, M. A. and Grudzenski, S. and Schwab, S. A. and Wiederseiner, M. and Heckmann, M. and Bautz, W. and Löbrich, M. and Uder, M. :
DNA double-strand breaks and their repair in blood lymphocytes of patients undergoing angiographic procedures.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/19448553?dopt=Citation]
In: Investigative Radiology, 44 (8) pp. 440-446.
[Article] , (2009)

Küfner, M. A. and Grudzenski, S. and Schwab, S. A. and Azoulay, S. and Heckmann, M. and Heinrich, M. C. and Löbrich, M. and Uder, M. :
X-ray-induced DNA double-strand breaks after angiographic examinations of different anatomic regions.
In: Rofo, 181 (4) pp. 374-380.
[Article] , (2009)

Rübe, C. E. and Grudzenski, S. and Kühne, M. and Dong, X. and Rief, N. and Löbrich, M. and Rübe, C. :
DNA double-strand break repair of blood lymphocytes and normal tissues analysed in a preclinical mouse model: implications for radiosensitivity testing.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/18927295?dopt=Citation]
In: Clinical Cancer Research, 14 (20) pp. 6546-6555.
[Article] , (2008)

Goodarzi, A. A. and Noon, A. and Deckbar, D. and Ziv, Y. and Shiloh, Y. and Löbrich, M. and Jeggo, P. A. :
ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/18657500?dopt=Citation]
In: Molecular Cell, 31 (2) pp. 167-177.
[Article] , (2008)

Toulany, M. and Kehlbach, R. and Florczak, U. and Sak, A. and Wang, S. and Chen, J. and Löbrich, M. and Rodemann, H. P. :
Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/18644989?dopt=Citation]
In: Molecular Cancer Therapeutics, 7 (7) pp. 1772-1781.
[Article] , (2008)

Rothkamm, K. and Gunasekara, K. and Warda, S. and Krempler, A. and Löbrich, M. :
Radiation-induced HPRT mutations resulting from misrejoined DNA double-strand breaks.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/18494542?dopt=Citation]
In: Radiation Research, 169 (6) pp. 639-648.
[Article] , (2008)

Seifert, M. and Scherer, S. J. and Edelmann, W. and Böhm, M. and Meineke, V. and Löbrich, M. and Tilgen, W. and Reichrath, J. :
The DNA-mismatch repair enzyme hMSH2 modulates UV-B-induced cell cycle arrest and apoptosis in melanoma cells.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/17611581?dopt=Citation]
In: Journal of Investigative Dermatology, 128 (1) pp. 203-213.
[Article] , (2008)

Jeggo, P. A. and Löbrich, M. :
DNA double-strand breaks: their cellular and clinical impact?
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/18066083?dopt=Citation]
In: Oncogene, 26 (56) pp. 7717-7719.
[Article] , (2007)

Kegel, P. and Riballo, E. and Kühne, M. and Jeggo, P. A. and Löbrich, M. :
X-irradiation of cells on glass slides has a dose doubling impact.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/17644493?dopt=Citation]
In: DNA Repair, 6 (11) pp. 1692-1697.
[Article] , (2007)

Löbrich, M. and Jeggo, P. A. :
The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/17943134?dopt=Citation]
In: Nature Reviews Cancer, 7 (11) pp. 861-869.
[Article] , (2007)

Krempler, A. and Deckbar, D. and Jeggo, P. A. and Löbrich, M. :
An imperfect G2M checkpoint contributes to chromosome instability following irradiation of S and G2 phase cells.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/17637566?dopt=Citation]
In: Cell Cycle, 6 (14) pp. 1682-1686.
[Article] , (2007)

Hunt, C. R. and Pandita, R. K. and Laszlo, A. and Higashikubo, R. and Agarwal, M. and Kitamura, T. and Gupta, A. and Rief, N. and Horikoshi, N. and Baskaran, R. and Lee, J. H. and Löbrich, M. and Paull, T. T. and Roti Roti, J. L. and Pandita, T. K. :
Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/17409407?dopt=Citation]
In: Cancer Research, 67 (7) pp. 3010-3017.
[Article] , (2007)

Deckbar, D. and Birraux, J. and Krempler, A. and Tchouandong, L. and Beucher, A. and Walker, S. and Stiff, T. and Jeggo, P. A. and Löbrich, M. :
Chromosome breakage after G2 checkpoint release.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/17353355?dopt=Citation]
In: Journal of Cell Biology, 176 (6) pp. 749-755.
[Article] , (2007)

Chen, B. P. and Uematsu, N. and Kobayashi, J. and Lerenthal, Y. and Krempler, A. and Yajima, H. and Löbrich, M. and Shiloh, Y. and Chen, D. J. :
Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/17189255?dopt=Citation]
In: Journal of Biological Chemistry, 282 (9) pp. 6582-6587.
[Article] , (2007)

Jeggo, P. A. and Löbrich, M. :
Contribution of DNA repair and cell cycle checkpoint arrest to the maintenance of genomic stability.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/16797253?dopt=Citation]
In: DNA Repair, 5 (9-10) pp. 1192-1198.
[Article] , (2006)

Löbrich, M. and Kiefer, J. :
Assessing the likelihood of severe side effects in radiotherapy.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/16425223?dopt=Citation]
In: International Journal of Cancer, 118 (11) pp. 2652-2656.
[Article] , (2006)

Jeggo, P. A. and Löbrich, M. :
Radiation-induced DNA damage responses.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/17351270?dopt=Citation]
In: Radiation Protection Dosimetry, 122 (1-4) pp. 124-127.
[Article] , (2006)

Kühne, M. and Urban, G. and Frankenberg, D. and Löbrich, M. :
DNA double-strand break misrejoining after exposure of primary human fibroblasts to CK characteristic X rays, 29 kVp X rays and 60Co gamma rays.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/16238445?dopt=Citation]
In: Radiation Research, 164 (5) pp. 669-676.
[Article] , (2005)

Löbrich, M. and Jeggo, P. A. :
The two edges of the ATM sword: co-operation between repair and checkpoint functions.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/16026874?dopt=Citation]
In: Radiotherapy and Oncology, 76 (2) pp. 112-118.
[Article] , (2005)

Löbrich, M. and Jeggo, P. A. :
Harmonising the response to DSBs: a new string in the ATM bow.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/15978533?dopt=Citation]
In: DNA Repair, 4 (7) pp. 749-759.
[Article] , (2005)

Löbrich, M. and Rief, N. and Kühne, M. and Heckmann, M. and Fleckenstein, J. and Rübe, C. and Uder, M. :
In vivo formation and repair of DNA double-strand breaks after computed tomography examinations.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/15956203?dopt=Citation]
In: Proceedings of the National Academy of Sciences USA, 102 (25) pp. 8984-8989.
[Article] , (2005)

Jeggo, P. A. and Löbrich, M. :
Artemis links ATM to double strand break rejoining.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/15684609?dopt=Citation]
In: Cell Cycle, 4 (3) pp. 359-362.
[Article] , (2005)

Riballo, E. and Kühne, M. and Rief, N. and Doherty, A. and Smith, G. C. M. and Recio, M. J. and Reis, C. and Dahm, K. and Fricke, A. and Krempler, A. and Parker, A. R. and Jackson, S. P. and Gennery, A. and Jeggo, P. A. and Löbrich, M. :
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/15574327?dopt=Citation]
In: Molecular Cell, 16 (5) pp. 715-724.
[Article] , (2004)

Stiff, T. and O'Driscoll, M. and Rief, N. and Iwabuchi, K. and Löbrich, M. and Jeggo, P. A. :
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/15059890?dopt=Citation]
In: Cancer Research, 64 (7) pp. 2390-2396.
[Article] , (2004)

Kühne, M. and Riballo, E. and Rief, N. and Rothkamm, K. and Jeggo, P. A. and Löbrich, M. :
A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/14744762?dopt=Citation]
In: Cancer Research, 64 (2) pp. 500-508.
[Article] , (2004)

Krüger, I. and Rothkamm, K. and Löbrich, M. :
Enhanced fidelity for rejoining radiation-induced DNA double-strand breaks in the G2 phase of Chinese hamster ovary cells.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/15148355?dopt=Citation]
In: Nucleic Acids Research, 32 (9) pp. 2677-2684.
[Article] , (2004)

Rothkamm, K. and Krüger, I. and Thompson, L. H. and Löbrich, M. :
Pathways of DNA double-strand break repair during the mammalian cell cycle.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/12897142?dopt=Citation]
In: Molecular Cell Biology, 23 (16) pp. 5706-5715.
[Article] , (2003)

Rothkamm, K. and Löbrich, M. :
Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/12679524?dopt=Citation]
In: Proceedings of the National Academy of Sciences USA, 100 (9) pp. 5057-5062.
[Article] , (2003)

Rothkamm, K. and Löbrich, M. :
Misrepair of radiation-induced DNA double-strand breaks and its relevance for tumorigenesis and cancer treatment (review).
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/12118342?dopt=Citation]
In: International Journal of Oncology, 21 (2) pp. 433-440.
[Article] , (2002)

Rydberg, B. and Heilbronn, L. and Holley, W. R. and Löbrich, M. and Zeitlin, C. and Chatterjee, A. and Cooper, P. K. :
Spatial distribution and yield of DNA double-strand breaks induced by 3-7 MeV helium ions in human fibroblasts.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/12071801?dopt=Citation]
In: Radiation Research, 158 (1) pp. 32-42.
[Article] , (2002)

Rief, N. and Löbrich, M. :
Efficient rejoining of radiation-induced DNA double-strand breaks in centromeric DNA of human cells.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/11927583?dopt=Citation]
In: Journal of Biological Chemistry, 277 (23) pp. 20572-20582.
[Article] , (2002)

Tabocchini, M. A. and Belli, M. and Campa, A. and Löbrich, M. and Sapora, O. and Simone, G. and Stenerlow, B. :
Induction and repair of DNA damage in human cells at different stages of differentiation.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/12194263?dopt=Citation]
In: Radiation Protection Dosimetry, 99 (1-4) pp. 123-128.
[Article] , (2002)

Kühne, M. and Rothkamm, K. and Löbrich, M. :
Physical and biological parameters affecting DNA double strand break misrejoining in mammalian cells.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/12194264?dopt=Citation]
In: Radiation Protection Dosimetry, 99 (1-4) pp. 129-132.
[Article] , (2002)

Rothkamm, K. and Kühne, M. and Jeggo, P. A. and Löbrich, M. :
Radiation-induced genomic rearrangements formed by nonhomologous end-joining of DNA double-strand breaks.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/11358801?dopt=Citation]
In: Cancer Research, 61 (10) pp. 3886-3893.
[Article] , (2001)

Tabocchini, M. A. and Rothkamm, K. and Signoretti, C. and Risse, J. and Sapora, O. and Löbrich, M. :
Formation and repair of DNA double-strand breaks in gamma-irradiated K562 cells undergoing erythroid differentiation.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/10980413?dopt=Citation]
In: Mutation Research, 461 (1) pp. 71-82.
[Article] , (2000)

Kühne, M. and Rothkamm, K. and Löbrich, M. :
No dose-dependence of DNA double-strand break misrejoining following alpha-particle irradiation.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/10923613?dopt=Citation]
In: International Journal of Radiation Biology, 76 (7) pp. 891-900.
[Article] , (2000)

Löbrich, M. and Kühne, M. and Wetzel, J. and Rothkamm, K. :
Joining of correct and incorrect DNA double-strand break ends in normal human and ataxia telangiectasia fibroblasts.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/10564587?dopt=Citation]
In: Genes Chromosomes Cancer, 27 (1) pp. 59-68.
[Article] , (2000)

Rothkamm, K. and Löbrich, M. :
Misrejoining of DNA double-strand breaks in primary and transformed human and rodent cells: a comparison between the HPRT region and other genomic locations.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/10343652?dopt=Citation]
In: Mutation Research, 433 (3) pp. 193-205.
[Article] , (1999)

Löbrich, M. and Cooper, P. K. and Rydberg, B. :
Joining of correct and incorrect DNA ends at double-strand breaks produced by high-linear energy transfer radiation in human fibroblasts.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/9840181?dopt=Citation]
In: Radiation Research, 150 (6) pp. 619-626.
[Article] , (1998)

Prise, K. M. and Ahnstrom, G. and Belli, M. and Carlsson, J. and Frankenberg, D. and Kiefer, J. and Löbrich, M. and Michael, B. D. and Nygren, J. and Simone, G. and Stenerlow, B. :
A review of dsb induction data for varying quality radiations.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/9712547?dopt=Citation]
In: International Journal of Radiation Biology, 74 (2) pp. 173-184.
[Article] , (1998)

Rydberg, B. and Löbrich, M. and Cooper, P. K. :
Repair of clustered DNA damage caused by high LET radiation in human fibroblasts.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/11542637?dopt=Citation]
In: Physica medica, 14, Su pp. 24-28. ISSN 1120-1797
[Article] , (1998)

Löbrich, M. :
Induction and repair of DNA double-strand breaks in human fibroblasts after particle irradiation.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/11542785?dopt=Citation]
In: Advances in Space Research, 22 (4) pp. 551-560.
[Article] , (1998)

Löbrich, M. and Cooper, P. K. and Rydberg, B. :
Non-random distribution of DNA double-strand breaks induced by particle irradiation.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/8947529?dopt=Citation]
In: International Journal of Radiation Biology, 70 (5) pp. 493-503.
[Article] , (1996)

Löbrich, M. and Rydberg, B. and Cooper, P. K. :
Random-breakage mapping method applied to human DNA sequences.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/8657558?dopt=Citation]
In: Nucleic Acids Research, 24 (10) pp. 1802-1808.
[Article] , (1996)

Löbrich, M. and Rydberg, B. and Cooper, P. K. :
Repair of x-ray-induced DNA double-strand breaks in specific Not I restriction fragments in human fibroblasts: joining of correct and incorrect ends.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/8618842?dopt=Citation]
In: Proceedings of the National Academy of Sciences USA, 92 (26) pp. 12050-12054.
[Article] , (1995)

Ikpeme, S. and Löbrich, M. and Akpa, T. and Schneider, E. and Kiefer, J. :
Heavy ion-induced DNA double-strand breaks with yeast as a model system.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/7652158?dopt=Citation]
In: Radiation and Environmental Biophysics, 34 (2) pp. 95-99.
[Article] , (1995)

Rydberg, B. and Löbrich, M. and Cooper, P. K. :
DNA double-strand breaks induced by high-energy neon and iron ions in human fibroblasts. I. Pulsed-field gel electrophoresis method.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/8052688?dopt=Citation]
In: Radiation Research, 139 (2) pp. 133-141.
[Article] , (1994)

Löbrich, M. and Rydberg, B. and Cooper, P. K. :
DNA double-strand breaks induced by high-energy neon and iron ions in human fibroblasts. II. Probing individual notI fragments by hybridization.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/8052689?dopt=Citation]
In: Radiation Research, 139 (2) pp. 142-151.
[Article] , (1994)

Löbrich, M. and Ikpeme, S. and Kiefer, J. :
DNA double-strand break measurement in mammalian cells by pulsed-field gel electrophoresis: an approach using restriction enzymes and gene probing.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/7912711?dopt=Citation]
In: International Journal of Radiation Biology, 65 (6) pp. 623-630.
[Article] , (1994)

Löbrich, M. and Ikpeme, S. and Kiefer, J. :
Measurement of DNA double-strand breaks in mammalian cells by pulsed-field gel electrophoresis: a new approach using rarely cutting restriction enzymes.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/8183988?dopt=Citation]
In: Radiation Research, 138 (2) pp. 186-192.
[Article] , (1994)

Löbrich, M. and Ikpeme, S. and Haub, P. and Weber, K. J. and Kiefer, J. :
DNA double-strand break induction in yeast by X-rays and alpha-particles measured by pulsed-field gel electrophoresis.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/7902393?dopt=Citation]
In: International Journal of Radiation Biology, 64 (5) pp. 539-546.
[Article] , (1993)

Löbrich, M. and Ikpeme, S. and Kiefer, J. :
Analysis of the inversion effect in pulsed field gel electrophoresis by a two-dimensional contour-clamped homogeneous electric field system.
[Online-Edition: http://www.ncbi.nlm.nih.gov/pubmed/8434797?dopt=Citation]
In: Analytical Biochemistry, 208 (1) pp. 65-73.
[Article] , (1993)

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