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Anzahl der Einträge: 93.

Langer, Kai ; Müller-Längle, Adriana ; Wempe, Jannik ; Laube, Bodo (2022)
Analysis of M4 Transmembrane Segments in NMDA Receptor Function: A Negative Allosteric Modulatory Site at the GluN1 M4 is Determining the Efficiency of Neurosteroid Modulation.
In: Frontiers in Pharmacology, 2022, 12
doi: 10.26083/tuprints-00020785
Artikel, Zweitveröffentlichung, Verlagsversion

Bernhard, Max ; Laube, Bodo (2022)
Thermophoretic analysis of ligand-specific conformational states of the inhibitory glycine receptor embedded in copolymer nanodiscs.
In: Scientific Reports, 2022, 10
doi: 10.26083/tuprints-00021126
Artikel, Zweitveröffentlichung, Verlagsversion

Langer, Kai ; Müller-Längle, Adriana ; Wempe, Jannik ; Laube, Bodo (2021)
Analysis of M4 Transmembrane Segments in NMDA Receptor Function : A Negative Allosteric Modulatory Site at the GluN1 M4 is Determining the Efficiency of Neurosteroid Modulation.
In: Frontiers in pharmacology, 12
doi: 10.3389/fphar.2021.769046
Artikel, Bibliographie

Bernhard, Max ; Laube, Bodo (2020)
Thermophoretic analysis of ligand-specific conformational states of the inhibitory glycine receptor embedded in copolymer nanodiscs.
In: Scientific reports, 10 (1)
doi: 10.1038/s41598-020-73157-2
Artikel, Bibliographie

Bernhard, Max ; Diefenbach, Mathias ; Biesalski, Markus ; Laube, Bodo (2020)
Electrical Sensing of Phosphonates by Functional Coupling of Phosphonate Binding Protein PhnD to Solid-State Nanopores.
In: ACS sensors, 5 (1)
doi: 10.1021/acssensors.9b02097
Artikel, Bibliographie

Müller-Längle, Adriana ; Lutz, Henrik ; Hehlgans, Stephanie ; Rödel, Franz ; Rau, Kerstin ; Laube, Bodo (2019)
NMDA Receptor-Mediated Signaling Pathways Enhance Radiation Resistance, Survival and Migration in Glioblastoma Cells-A Potential Target for Adjuvant Radiotherapy.
In: Cancers, 11 (4)
doi: 10.3390/cancers11040503
Artikel, Bibliographie

Lutz, Henrik ; Nguyen, Thy ; Joswig, Juliane ; Rau, Kerstin ; Laube, Bodo (2019)
NMDA Receptor Signaling Mediates cFos Expression via Top2β-Induced DSBs in Glioblastoma Cells.
In: Cancers, 2019, 11 (3)
doi: 10.3390/cancers11030306
Artikel, Zweitveröffentlichung

Schönrock, Michael ; Thiel, Gerhard ; Laube, Bodo (2019)
Coupling of a viral K+-channel with a glutamate-binding-domain highlights the modular design of ionotropic glutamate-receptors.
In: Communications biology, 2
doi: 10.1038/s42003-019-0320-y
Artikel, Bibliographie

Bledsoe, Douglas ; Vacca, Bryanna ; Laube, Bodo ; Klein, Bradley G. ; Costa, Blaise (2019)
Ligand binding domain interface: A tipping point for pharmacological agents binding with GluN1/2A subunit containing NMDA receptors.
In: European journal of pharmacology, 844
doi: 10.1016/j.ejphar.2018.12.023
Artikel, Bibliographie

Schönrock, Michael ; Thiel, Gerhard ; Laube, Bodo (2019)
Coupling of a viral K+-channel with a glutamate-binding-domain highlights the modular design of ionotropic glutamate-receptors.
In: Communications Biology, 2019, 2 (1)
doi: 10.1038/s42003-019-0320-y
Artikel, Zweitveröffentlichung

Müller-Längle, Adriana ; Lutz, Henrik ; Hehlgans, Stephanie ; Rödel, Franz ; Rau, Kerstin ; Laube, Bodo (2019)
NMDA Receptor-Mediated Signaling Pathways Enhance Radiation Resistance, Survival and Migration in Glioblastoma Cells — A Potential Target for Adjuvant Radiotherapy.
In: Cancers, 2019, 11 (4)
doi: 10.3390/cancers11040503
Artikel, Zweitveröffentlichung

Richter, Max C. ; Ludewig, Susann ; Winschel, Alex ; Abel, Tobias ; Bold, Charlotte ; Salzburger, Leonie R. ; Klein, Susanne ; Han, Kang ; Weyer, Sascha W. ; Fritz, Ann-Kristina ; Laube, Bodo ; Wolfer, David P. ; Buchholz, Christian J. ; Korte, Martin ; Müller, Ulrike C. (2018)
Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition.
In: The EMBO journal, 37 (11)
doi: 10.15252/embj.201798335
Artikel, Bibliographie

Ensinger, Wolfgang ; Ali, Mubarak ; Nasir, Saima ; Duznovic, Ivana ; Trautmann, Christina ; Toimil-Molares, Maria Eugenia ; Distefano, Giuseppa R. ; Laube, Bodo ; Bernhard, Max ; MikoschWersching, Melanie ; Schlaak, Helmut F. ; El Khoury, Mario (2018)
The iNAPO Project: biomimetic nanopores for a new generation of lab-on-chip micro sensors.
In: International Journal of Theoretical and Applied Nanotechnology
doi: 10.11159/ijtan.2018.004
Artikel, Bibliographie

Platzer, Konrad ; Yuan, Hongjie ; Schütz, Hannah ; Winschel, Alexander ; Chen, Wenjuan ; Hu, Chun ; Kusumoto, Hirofumi ; Heyne, Henrike O. ; Helbig, Katherine L. ; Tang, Sha ; Willing, Marcia C. ; Tinkle, Brad T. ; Adams, Darius J. ; Depienne, Christel ; Keren, Boris ; Mignot, Cyril ; Frengen, Eirik ; Strømme, Petter ; Biskup, Saskia ; Döcker, Dennis ; Strom, Tim M. ; Mefford, Heather C. ; Myers, Candace T. ; Muir, Alison M. ; LaCroix, Amy ; Sadleir, Lynette ; Scheffer, Ingrid E. ; Brilstra, Eva ; Haelst, Mieke M. van ; Smagt, Jasper J. van der ; Bok, Levinus A. ; Møller, Rikke S. ; Jensen, Uffe B. ; Millichap, John J. ; Berg, Anne T. ; Goldberg, Ethan M. ; De Bie, Isabelle ; Fox, Stephanie ; Major, Philippe ; Jones, Julie R. ; Zackai, Elaine H. ; Abou Jamra, Rami ; Rolfs, Arndt ; Leventer, Richard J. ; Lawson, John A. ; Roscioli, Tony ; Jansen, Floor E. ; Ranza, Emmanuelle ; Korff, Christian M. ; Lehesjoki, Anna-Elina ; Courage, Carolina ; Linnankivi, Tarja ; Smith, Douglas R. ; Stanley, Christine ; Mintz, Mark ; McKnight, Dianalee ; Decker, Amy ; Tan, Wen-Hann ; Tarnopolsky, Mark A. ; Brady, Lauren I. ; Wolff, Markus ; Dondit, Lutz ; Pedro, Helio F. ; Parisotto, Sarah E. ; Jones, Kelly L. ; Patel, Anup D. ; Franz, David N. ; Vanzo, Rena ; Marco, Elysa ; Ranells, Judith D. ; Di Donato, Nataliya ; Dobyns, William B. ; Laube, Bodo ; Traynelis, Stephen F. ; Lemke, Johannes R. (2017)
GRIN2B encephalopathy: novel findings on phenotype, variant clustering, functional consequences and treatment aspects.
In: Journal of medical genetics, 54 (7)
Artikel, Bibliographie

Schoenrock, Michael ; Poci, Alina ; Thiel, Gerhard ; Laube, Bodo (2017)
Design of a Glutamate-Activated Potassium Channel upon Fusion of the Ligand-Binding Domain of the Mammalian AMPA Receptor Glua1 to the Channel Pore of the Viral ATCV-1 KCV K+ Channel.
In: Biophysical journal, 112 (3)
Artikel, Bibliographie

Bernhard, Max ; Laube, Bodo (2017)
Functional Coupling of Bacterial Binding Protein with the Channel Pore of an Ionotropic Glutamate Receptor.
In: Biophysical journal, 112 (3)
Artikel, Bibliographie

Bledsoe, Douglas ; Tamer, Ceyhun ; Mesic, Ivana ; Madry, Christian ; Klein, Bradley G. ; Laube, Bodo ; Costa, Blaise M. (2017)
Positive modulatory interactions of NMDA receptor GluN1/2B ligand binding domains attenuate antagonists activity.
In: Frontiers in Pharmacology, 8
doi: 10.3389/fphar.2017.00229
Artikel, Bibliographie

Ensinger, Wolfgang ; Ali, Mubarak ; Nasir, Saima ; Duznovic, Ivana ; Trautmann, Christina ; Toimil-Molares, Maria Eugenia ; Distefano, Giuseppa R. ; Laube, Bodo ; Bernhard, Max ; Mikosch-Wersching, Melanie ; Schlaak, Helmut F. ; El Khoury, Mario (2017)
The iNAPO Project: Biomimetic Nanopores for a New Generation of Lab-on-Chip Micro Sensors.
2nd World Congress on Recent Advances in Nanotechnology (RAN’17). Barcelona, Spanien (4. - 6. April 2017)
doi: 10.11159/icnnfc17.141
Konferenzveröffentlichung, Bibliographie

Lemke, Johannes R. ; Geider, Kirsten ; Helbig, Katherine L. ; Heyne, Henrike O. ; Schütz, Hannah ; Hentschel, Julia ; Courage, Carolina ; Depienne, Christel ; Nava, Caroline ; Heron, Delphine ; Møller, Rikke S. ; Hjalgrim, Helle ; Lal, Dennis ; Neubauer, Bernd A. ; Nürnberg, Peter ; Thiele, Holger ; Kurlemann, Gerhard ; Arnold, Georgianne L. ; Bhambhani, Vikas ; Bartholdi, Deborah ; Pedurupillay, Christeen Ramane J. ; Misceo, Doriana ; Frengen, Eirik ; Strømme, Petter ; Dlugos, Dennis J. ; Doherty, Emily S. ; Bijlsma, Emilia K. ; Ruivenkamp, Claudia A. ; Hoffer, Mariette J. V. ; Goldstein, Amy ; Rajan, Deepa S. ; Narayanan, Vinodh ; Ramsey, Keri ; Belnap, Newell ; Schrauwen, Isabelle ; Richholt, Ryan ; Koeleman, Bobby P. C. ; Sá, Joaquim ; Mendonça, Carla ; Kovel, Carolien de ; Weckhuysen, Sarah ; Hardies, Katia ; De Jonghe, Peter ; De Meirleir, Linda ; Milh, Mathieu ; Badens, Catherine ; Lebrun, Marine ; Busa, Tiffany ; Francannet, Christine ; Piton, Amélie ; Riesch, Erik ; Biskup, Saskia ; Vogt, Heinrich ; Dorn, Thomas ; Helbig, Ingo ; Michaud, Jacques L. ; Laube, Bodo ; Syrbe, Steffen (2016)
Delineating the GRIN1 phenotypic spectrum: A distinct genetic NMDA receptor encephalopathy.
In: Neurology, 86 (23)
Artikel, Bibliographie

Mesic, Ivana ; Madry, Christian ; Geider, Kirsten ; Bernhard, Max ; Betz, Heinrich ; Laube, Bodo (2016)
The N-terminal domain of the GluN3A subunit determines the efficacy of glycine-activated NMDA receptors.
In: Neuropharmacology, 105
Artikel, Bibliographie

Lynagh, Timothy ; Beech, Robin N. ; Lalande, Maryline J. ; Keller, Kevin ; Cromer, Brett A. ; Wolstenholme, Adrian J. ; Laube, Bodo (2015)
Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels.
In: Scientific reports, 24 (5)
Artikel, Bibliographie

Lynagh, Timothy ; Cromer, Brett A. ; Dufour, Vanessa ; Laube, Bodo (2014)
Comparative pharmacology of flatworm and roundworm glutamate-gated chloride channels: Implications for potential anthelmintics.
In: International journal for parasitology. Drugs and drug resistance, 4 (3)
Artikel, Bibliographie

Lemke, Johannes R. ; Hendrickx, Rik ; Geider, Kirsten ; Laube, Bodo ; Schwake, Michael ; Harvey, Robert J. ; James, Victoria M. ; Pepler, Alex ; Steiner, Isabelle ; Hörtnagel, Konstanze ; Neidhardt, John ; Ruf, Susanne ; Wolff, Markus ; Bartholdi, Deborah ; Caraballo, Roberto ; Platzer, Konrad ; Suls, Arvid ; De Jonghe, Peter ; Biskup, Saskia ; Weckhuysen, Sarah (2014)
GRIN2B mutations in West syndrome and intellectual disability with focal epilepsy.
In: Annals of neurology, 75 (1)
Artikel, Bibliographie

Lynagh, Timothy ; Laube, Bodo (2014)
Opposing effects of the anesthetic propofol at pentameric ligand-gated ion channels mediated by a common site.
In: The Journal of neuroscience : the official journal of the Society for Neuroscience, 34 (6)
Artikel, Bibliographie

Spiczak, Sarah von ; Lal, D. ; Reinthaler, E. M. ; Steiner, I. ; Nothnagel, M. ; Laube, Bodo ; Schwake, M. ; Hoffmann, P. ; Herms, S. ; Altmüller, J. ; Toliat, M. R. ; Thiele, H. ; Nürnberg, P. ; Wilhelm, C. ; Stephani, U. ; Helbig, I. ; Lerche, H. ; Zimprich, F. ; Neubauer, B. A. ; Biskup, S. ; Lemke, J. R. (2013)
Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes.
In: Epilepsia, 54
Artikel, Bibliographie

Lemke, Johannes R. ; Lal, Dennis ; Reinthaler, Eva M. ; Steiner, Isabelle ; Nothnagel, Michael ; Alber, Michael ; Geider, Kirsten ; Laube, Bodo ; Schwake, Michael ; Finsterwalder, Katrin ; Franke, Andre ; Schilhabel, Markus ; Jähn, Johanna A. ; Muhle, Hiltrud ; Boor, Rainer ; Paesschen, Wim van ; Caraballo, Roberto ; Fejerman, Natalio ; Weckhuysen, Sarah ; De Jonghe, Peter ; Larsen, Jan ; Møller, Rikke S. ; Hjalgrim, Helle ; Addis, Laura ; Tang, Shan ; Hughes, Elaine ; Pal, Deb K. ; Veri, Kadi ; Vaher, Ulvi ; Talvik, Tiina ; Dimova, Petia ; Guerrero López, Rosa ; Serratosa, José M. ; Linnankivi, Tarja ; Lehesjoki, Anna-Elina ; Ruf, Susanne ; Wolff, Markus ; Buerki, Sarah ; Wohlrab, Gabriele ; Kroell, Judith ; Datta, Alexandre N. ; Fiedler, Barbara ; Kurlemann, Gerhard ; Kluger, Gerhard ; Hahn, Andreas ; Haberlandt, D. Edda ; Kutzer, Christina ; Sperner, Jürgen ; Becker, Felicitas ; Weber, Yvonne G. ; Feucht, Martha ; Steinböck, Hannelore ; Neophythou, Birgit ; Ronen, Gabriel M. ; Gruber-Sedlmayr, Ursula ; Geldner, Julia ; Harvey, Robert J. ; Hoffmann, Per ; Herms, Stefan ; Altmüller, Janine ; Toliat, Mohammad R. ; Thiele, Holger ; Nürnberg, Peter ; Wilhelm, Christian ; Stephani, Ulrich ; Helbig, Ingo ; Lerche, Holger ; Zimprich, Fritz ; Neubauer, Bernd A. ; Biskup, Saskia ; Spiczak, Sarah von (2013)
Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes.
In: Nature genetics, 45 (9)
Artikel, Bibliographie

Lynagh, Timothy ; Kunz, Alexander ; Laube, Bodo (2013)
Propofol modulation of α1 glycine receptors does not require a structural transition at adjacent subunits that is crucial to agonist-induced activation.
In: ACS chemical neuroscience, 4 (11)
Artikel, Bibliographie

Dutertre, Sébastien ; Drwal, Malgorzata ; Laube, Bodo ; Betz, Heinrich (2012)
Probing the pharmacological properties of distinct subunit interfaces within heteromeric glycine receptors reveals a functional ββ agonist binding site.
In: Journal of neurochemistry, 122 (1)
Artikel, Bibliographie

Kallenborn-Gerhardt, Wiebke ; Lu, Ruirui ; Lorenz, Jana ; Gao, Wei ; Weiland, Jessica ; Del Turco, Domenico ; Deller, Thomas ; Laube, Bodo ; Betz, Heinrich ; Geisslinger, Gerd ; Schmidtko, Achim (2012)
Prolonged zymosan-induced inflammatory pain hypersensitivity in mice lacking glycine receptor alpha2.
In: Behavioural brain research, 226 (1)
Artikel, Bibliographie

Costa, Blaise Mathias ; Irvine, Mark W. ; Fang, Guangyu ; Eaves, Richard J. ; Mayo-Martin, Maria Belen ; Laube, Bodo ; Jane, David E. ; Monaghan, Daniel T. (2012)
Structure-activity relationships for allosteric NMDA receptor inhibitors based on 2-naphthoic acid.
In: Neuropharmacology, 62 (4)
Artikel, Bibliographie

Pult, Frauke ; Fallah, Ghada ; Braam, Ursula ; Detro-Dassen, Silvia ; Niculescu, Cristina ; Laube, Bodo ; Schmalzing, Günther (2011)
Robust post-translocational N-glycosylation at the extreme C-terminus of membrane and secreted proteins in Xenopus laevis oocytes and HEK293 cells.
In: Glycobiology, 21 (9)
Artikel, Bibliographie

Endele, Sabine ; Rosenberger, Georg ; Geider, Kirsten ; Popp, Bernt ; Tamer, Ceyhun ; Stefanova, Irina ; Milh, Mathieu ; Kortüm, Fanny ; Fritsch, Angela ; Pientka, Friederike K. ; Hellenbroich, Yorck ; Kalscheuer, Vera M. ; Kohlhase, Jürgen ; Moog, Ute ; Rappold, Gudrun ; Rauch, Anita ; Ropers, Hans-Hilger ; Spiczak, Sarah von ; Tönnies, Holger ; Villeneuve, Nathalie ; Villard, Laurent ; Zabel, Bernhard ; Zenker, Martin ; Laube, Bodo ; Reis, André ; Wieczorek, Dagmar ; Maldergem, Lionel van ; Kutsche, Kerstin (2010)
Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes.
In: Nature genetics, 42 (11)
Artikel, Bibliographie

Madry, Christian ; Betz, Heinrich ; Geiger, Jörg R. P. ; Laube, Bodo (2010)
Potentiation of Glycine-Gated NR1/NR3A NMDA Receptors Relieves Ca-Dependent Outward Rectification.
In: Frontiers in molecular neuroscience, 3
Artikel, Bibliographie

Haeger, Svenja ; Kuzmin, Dmitry ; Detro-Dassen, Silvia ; Lang, Niklas ; Kilb, Michael ; Tsetlin, Victor ; Betz, Heinrich ; Laube, Bodo ; Schmalzing, Günther (2010)
An intramembrane aromatic network determines pentameric assembly of Cys-loop receptors.
In: Nature structural & molecular biology, 17 (1)
Artikel, Bibliographie

Schumann, Tanja ; Grudzinska, Joanna ; Kuzmin, Dmitry ; Betz, Heinrich ; Laube, Bodo (2009)
Binding-site mutations in the alpha1 subunit of the inhibitory glycine receptor convert the inhibitory metal ion Cu2+ into a positive modulator.
In: Neuropharmacology, 56 (1)
Artikel, Bibliographie

Laube, Bodo ; Betz, Heinrich (2009)
Die duale Rolle des Neurotransmitters Glyzin im zentralen Nervensystem.
In: Jahrbuch 2009 der Max-Planck-Gesellschaft
Artikel, Bibliographie

Maksay, Gábor ; Laube, Bodo ; Schemm, Rudolf ; Grudzinska, Joanna ; Drwal, Malgorzata ; Betz, Heinrich (2009)
Different binding modes of tropeines mediating inhibition and potentiation of alpha1 glycine receptors.
In: Journal of neurochemistry, 109 (6)
Artikel, Bibliographie

Dutertre, S. ; Kuzmin, D. ; Laube, Bodo ; Betz, H.
Hrsg.: Lajtha, A. (2009)
Inhibitory glycine receptors. Neural signal mechanism "Channels: structure, cellular function and disorder".
In: Handbook of Neurochemistry and Molecular Neurobiology
Buchkapitel, Bibliographie

Schüler, Thomas ; Mesic, Ivana ; Madry, Christian ; Bartholomäus, Ingo ; Laube, Bodo (2008)
Formation of NR1/NR2 and NR1/NR3 heterodimers constitutes the initial step in N-methyl-D-aspartate receptor assembly.
In: The Journal of biological chemistry, 283 (1)
Artikel, Bibliographie

Maksay, Gábor ; Bíró, Tímea ; Laube, Bodo ; Nemes, Péter (2008)
Hyperekplexia mutation R271L of alpha1 glycine receptors potentiates allosteric interactions of nortropeines, propofol and glycine with [3H]strychnine binding.
In: Neurochemistry international, 52 (1-2)
Artikel, Bibliographie

Grudzinska, Joanna ; Schumann, Tanja ; Schemm, Rudolf ; Betz, Heinrich ; Laube, Bodo (2008)
Mutations within the agonist-binding site convert the homomeric alpha1 glycine receptor into a Zn2+-activated chloride channel.
In: Channels (Austin, Tex.), 2 (1)
Artikel, Bibliographie

Madry, Christian ; Betz, Heinrich ; Geiger, Jörg R. P. ; Laube, Bodo (2008)
Supralinear potentiation of NR1/NR3A excitatory glycine receptors by Zn2+ and NR1 antagonist.
In: Proceedings of the National Academy of Sciences of the United States of America, 105 (34)
Artikel, Bibliographie

Maier, Wolfgang ; Schemm, Rudolf ; Grewer, Christof ; Laube, Bodo (2007)
Disruption of interdomain interactions in the glutamate binding pocket affects differentially agonist affinity and efficacy of N-methyl-D-aspartate receptor activation.
In: The Journal of biological chemistry, 282 (3)
Artikel, Bibliographie

Laube, Bodo (2007)
Dr. Jekyll & Mr. Hyde - das janusköpfige Zink.
In: BIOforum, 30 (3)
Artikel, Bibliographie

Papadopoulos, Theofilos ; Korte, Martin ; Eulenburg, Volker ; Kubota, Hisahiko ; Retiounskaia, Marina ; Harvey, Robert J. ; Harvey, Kirsten ; O'Sullivan, Gregory A. ; Laube, Bodo ; Hülsmann, Swen ; Geiger, Jörg R. P. ; Betz, Heinrich (2007)
Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin-deficient mice.
In: The EMBO journal, 26 (17)
Artikel, Bibliographie

Madry, Christian ; Mesic, Ivana ; Betz, Heinrich ; Laube, Bodo (2007)
The N-terminal domains of both NR1 and NR2 subunits determine allosteric Zn2+ inhibition and glycine affinity of N-methyl-D-aspartate receptors.
In: Molecular pharmacology, 72 (6)
Artikel, Bibliographie

Madry, Christian ; Mesic, Ivana ; Bartholomäus, Ingo ; Nicke, Annette ; Betz, Heinrich ; Laube, Bodo (2007)
Principal role of NR3 subunits in NR1/NR3 excitatory glycine receptor function.
In: Biochemical and biophysical research communications, 354 (1)
Artikel, Bibliographie

Betz, Heinrich ; Laube, Bodo (2006)
Glycine receptors: recent insights into their structural organization and functional diversity.
In: Journal of neurochemistry, 97 (6)
Artikel, Bibliographie

Hirzel, Klaus ; Müller, Ulrike ; Latal, A.Tobias ; Hülsmann, Swen ; Grudzinska, Joanna ; Seeliger, Mathias W. ; Betz, Heinrich ; Laube, Bodo (2006)
Hyperekplexia phenotype of glycine receptor alpha1 subunit mutant mice identifies Zn(2+) as an essential endogenous modulator of glycinergic neurotransmission.
In: Neuron, 52 (4)
Artikel, Bibliographie

Maier, Wolfgang ; Corrie, John E. T. ; Papageorgiou, George ; Laube, Bodo ; Grewer, Christof (2005)
Comparative analysis of inhibitory effects of caged ligands for the NMDA receptor.
In: Journal of neuroscience methods, 142 (1)
Artikel, Bibliographie

Grudzinska, Joanna ; Schemm, Rudolf ; Haeger, Svenja ; Nicke, Annette ; Schmalzing, Guenther ; Betz, Heinrich ; Laube, Bodo (2005)
The beta subunit determines the ligand binding properties of synaptic glycine receptors.
In: Neuron, 45 (5)
Artikel, Bibliographie

Kondratskaya, Elena L. ; Betz, Heinrich ; Krishtal, Oleg A. ; Laube, Bodo (2005)
The beta subunit increases the ginkgolide B sensitivity of inhibitory glycine receptors.
In: Neuropharmacology, 49 (6)
Artikel, Bibliographie

Laube, Bodo ; Betz, H.
Hrsg.: Lennarz, William (2004)
Glycine receptors.
In: Encyclopedia of Biological Chemistry
Buchkapitel, Bibliographie

Laube, Bodo ; Schemm, Rudolf ; Betz, Heinrich (2004)
Molecular determinants of ligand discrimination in the glutamate-binding pocket of the NMDA receptor.
In: Neuropharmacology, 47 (7)
Artikel, Bibliographie

O'Shea, Sean Michael ; Becker, Lore ; Weiher, Hans ; Betz, Heinrich ; Laube, Bodo (2004)
Propofol restores the function of "hyperekplexic" mutant glycine receptors in Xenopus oocytes and mice.
In: The Journal of neuroscience : the official journal of the Society for Neuroscience, 24 (9)
Artikel, Bibliographie

Ortinau, Stefanie ; Laube, Bodo ; Zimmermann, Herbert (2003)
ATP inhibits NMDA receptors after heterologous expression and in cultured hippocampal neurons and attenuates NMDA-mediated neurotoxicity.
In: The Journal of neuroscience : the official journal of the Society for Neuroscience, 23 (12)
Artikel, Bibliographie

Gomeza, Jesús ; Ohno, Koji ; Hülsmann, Swen ; Armsen, Wencke ; Eulenburg, Volker ; Richter, Diethelm W. ; Laube, Bodo ; Betz, Heinrich (2003)
Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality.
In: Neuron, 40 (4)
Artikel, Bibliographie

Foucaud, Bernard ; Laube, Bodo ; Schemm, Rudolf ; Kreimeyer, Annett ; Goeldner, Maurice ; Betz, Heinrich (2003)
Structural model of the N-methyl-D-aspartate receptor glycine site probed by site-directed chemical coupling.
In: The Journal of biological chemistry, 278 (26)
Artikel, Bibliographie

Sadtler, Sven ; Laube, Bodo ; Lashub, Alhassan ; Nicke, Annette ; Betz, Heinrich ; Schmalzing, Günther (2003)
A basic cluster determines topology of the cytoplasmic M3-M4 loop of the glycine receptor alpha1 subunit.
In: The Journal of biological chemistry, 278 (19)
Artikel, Bibliographie

Perret, P. ; Laube, Bodo ; Schemm, R. ; Betz, H. ; Goeldner, M. ; Foucaud, B. (2002)
Affinity labeling of cysteine-mutants evidences contact residues in modeled receptor binding sites.
In: Journal of receptor and signal transduction research, 22 (1-4)
Artikel, Bibliographie

Maksay, Gábor ; Bíró, Tímea ; Laube, Bodo (2002)
Hyperekplexia mutation of glycine receptors: decreased gating efficacy with altered binding thermodynamics.
In: Biochemical pharmacology, 64 (2)
Artikel, Bibliographie

Laube, Bodo ; Maksay, Gábor ; Schemm, Rudolf ; Betz, Heinrich (2002)
Modulation of glycine receptor function: a novel approach for therapeutic intervention at inhibitory synapses?
In: Trends in pharmacological sciences, 23 (11)
Artikel, Bibliographie

Laube, Bodo (2002)
Potentiation of inhibitory glycinergic neurotransmission by Zn2+: a synergistic interplay between presynaptic P2X2 and postsynaptic glycine receptors.
In: The European journal of neuroscience, 16 (6)
Artikel, Bibliographie

Wittekindt, B. ; Malany, S. ; Schemm, R. ; Otvos, L. ; Maccecchini, M. L. ; Laube, Bodo ; Betz, H. (2001)
Point mutations identify the glutamate binding pocket of the N-methyl-D-aspartate receptor as major site of conantokin-G inhibition.
In: Neuropharmacology, 41 (6)
Artikel, Bibliographie

Maksay, G. ; Laube, Bodo ; Betz, H. (2001)
Subunit-specific modulation of glycine receptors by neurosteroids.
In: Neuropharmacology, 41 (3)
Artikel, Bibliographie

Büttner, C. ; Sadtler, S. ; Leyendecker, A. ; Laube, Bodo ; Griffon, N. ; Betz, H. ; Schmalzing, G. (2001)
Ubiquitination precedes internalization and proteolytic cleavage of plasma membrane-bound glycine receptors.
In: The Journal of biological chemistry, 276 (46)
Artikel, Bibliographie

Laube, Bodo ; Kuhse, J. ; Betz, H. (2000)
Kinetic and mutational analysis of Zn2+ modulation of recombinant human inhibitory glycine receptors.
In: The Journal of physiology, (2)
doi: 10.1111/j.1469-7793.2000.t01-1-00215.x
Artikel, Bibliographie

Harvey, R. J. ; Schmieden, V. ; Holst, A. von ; Laube, Bodo ; Rohrer, H. ; Betz, H. (2000)
Glycine receptors containing the alpha4 subunit in the embryonic sympathetic nervous system, spinal cord and male genital ridge.
In: The European journal of neuroscience, 12 (3)
Artikel, Bibliographie

Wittekindt, B. ; Betz, H. ; Laube, Bodo (2000)
Subunit-dependent inhibition of recombinant rodent N-methyl-D-aspartate receptors by a HIV-1 glycoprotein 120 derived peptide.
In: Neuroscience letters, 280 (2)
Artikel, Bibliographie

Kreimeyer, A. ; Laube, Bodo ; Sturgess, M. ; Goeldner, M. ; Foucaud, B. (1999)
Evaluation and biological properties of reactive ligands for the mapping of the glycine site on the N-methyl-D-aspartate (NMDA) receptor.
In: Journal of medicinal chemistry, 42 (21)
Artikel, Bibliographie

Kins, S. ; Kuhse, J. ; Laube, Bodo ; Betz, H. ; Kirsch, J. (1999)
Incorporation of a gephyrin-binding motif targets NMDA receptors to gephyrin-rich domains in HEK 293 cells.
In: The European journal of neuroscience, 11 (2)
Artikel, Bibliographie

Kneussel, M. ; Brandstätter, J. H. ; Laube, Bodo ; Stahl, S. ; Müller, U. ; Betz, H. (1999)
Loss of postsynaptic GABA(A) receptor clustering in gephyrin-deficient mice.
In: The Journal of neuroscience : the official journal of the Society for Neuroscience, 19 (21)
Artikel, Bibliographie

Laube, Bodo ; Betz, H. (1999)
Purification and heterologous expression of inhibitory glycine receptors.
In: Methods in enzymology, 294
Artikel, Bibliographie

Kreimeyer, A. ; Laube, Bodo ; Sturgess, M. ; Goeldner, M. ; Foucaud, B. (1999)
Reactive affinity probes for the mapping of the glycine-binding site of the NMDA receptor NR1 subunit.
In: Journal of receptor and signal transduction research, 19 (1-4)
Artikel, Bibliographie

Maksay, G. ; Laube, Bodo ; Betz, H. (1999)
Selective blocking effects of tropisetron and atropine on recombinant glycine receptors.
In: Journal of neurochemistry, 73 (2)
Artikel, Bibliographie

Betz, H. ; Kuhse, J. ; Schmieden, V. ; Laube, Bodo ; Kirsch, J. ; Harvey, R. J. (1999)
Structure and functions of inhibitory and excitatory glycine receptors.
In: Annals of the New York Academy of Sciences, 868
Artikel, Bibliographie

Honer, M. ; Benke, D. ; Laube, Bodo ; Kuhse, J. ; Heckendorn, R. ; Allgeier, H. ; Angst, C. ; Monyer, H. ; Seeburg, P. H. ; Betz, H. ; Möhler, H. (1998)
Differentiation of glycine antagonist sites of N-methyl-D-aspartate receptor subtypes. Preferential interaction of CGP 61594 with NR1/2B receptors.
In: The Journal of biological chemistry, 273 (18)
Artikel, Bibliographie

Laube, Bodo ; Kuhse, J. ; Betz, H. (1998)
Evidence for a tetrameric structure of recombinant NMDA receptors.
In: The Journal of neuroscience : the official journal of the Society for Neuroscience, 18 (8)
Artikel, Bibliographie

Ivanovic, A. ; Reiländer, H. ; Laube, Bodo ; Kuhse, J. (1998)
Expression and initial characterization of a soluble glycine binding domain of the N-methyl-D-aspartate receptor NR1 subunit.
In: The Journal of biological chemistry, 273 (32)
Artikel, Bibliographie

Nikolic, Z. ; Laube, Bodo ; Weber, R. G. ; Lichter, P. ; Kioschis, P. ; Poustka, A. ; Mülhardt, C. ; Becker, C. M. (1998)
The human glycine receptor subunit alpha3. Glra3 gene structure, chromosomal localization, and functional characterization of alternative transcripts.
In: The Journal of biological chemistry, 273 (31)
Artikel, Bibliographie

Laube, Bodo ; Hirai, H. ; Sturgess, M. ; Betz, H. ; Kuhse, J. (1997)
Molecular determinants of agonist discrimination by NMDA receptor subunits: analysis of the glutamate binding site on the NR2B subunit.
In: Neuron, 18 (3)
Artikel, Bibliographie

Garcia-Guzman, M. ; Soto, F. ; Laube, Bodo ; Stühmer, W. (1996)
Molecular cloning and functional expression of a novel rat heart P2X purinoceptor.
In: FEBS letters, 388 (2-3)
Artikel, Bibliographie

Hirai, H. ; Kirsch, J. ; Laube, Bodo ; Betz, H. ; Kuhse, J. (1996)
The glycine binding site of the N-methyl-D-aspartate receptor subunit NR1: identification of novel determinants of co-agonist potentiation in the extracellular M3-M4 loop region.
In: Proceedings of the National Academy of Sciences of the United States of America, 93 (12)
Artikel, Bibliographie

Laube, Bodo ; Langosch, D. ; Betz, H. ; Schmieden, V. (1995)
Hyperekplexia mutations of the glycine receptor unmask the inhibitory subsite for beta-amino-acids.
In: Neuroreport, 6 (6)
Artikel, Bibliographie

Laube, Bodo ; Kuhse, J. ; Rundström, N. ; Kirsch, J. ; Schmieden, V. ; Betz, H. (1995)
Modulation by zinc ions of native rat and recombinant human inhibitory glycine receptors.
In: The Journal of physiology, 483
Artikel, Bibliographie

Langosch, D. ; Laube, Bodo ; Rundström, N. ; Schmieden, V. ; Bormann, J. ; Betz, H. (1994)
Decreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexia.
In: The EMBO journal, 13 (18)
Artikel, Bibliographie

Kuryatov, A. ; Laube, Bodo ; Betz, H. ; Kuhse, J. (1994)
Mutational analysis of the glycine-binding site of the NMDA receptor: structural similarity with bacterial amino acid-binding proteins.
In: Neuron, 12 (6)
Artikel, Bibliographie

Betz, H. ; Kuhse, J. ; Fischer, M. ; Schmieden, V. ; Laube, Bodo ; Kuryatov, A. ; Langosch, D. ; Meyer, G. ; Bormann, J. ; Rundström, N. (1994)
Structure, diversity and synaptic localization of inhibitory glycine receptors.
In: Journal of physiology, Paris, 88 (4)
Artikel, Bibliographie

Kuhse, J. ; Laube, Bodo ; Magalei, D. ; Betz, H. (1993)
Assembly of the inhibitory glycine receptor: identification of amino acid sequence motifs governing subunit stoichiometry.
In: Neuron, 11 (6)
Artikel, Bibliographie

Ultsch, A. ; Schuster, C. M. ; Laube, Bodo ; Betz, H. ; Schmitt, B. (1993)
Glutamate receptors of Drosophila melanogaster. Primary structure of a putative NMDA receptor protein expressed in the head of the adult fly.
In: FEBS letters, 324 (2)
Artikel, Bibliographie

Laube, Bodo ; Kuryatov, A. ; Kuhse, J. ; Betz, H. (1993)
Glycine-glutamate interactions at the NMDA receptor: role of cysteine residues.
In: FEBS letters, 335 (3)
Artikel, Bibliographie

Ultsch, A. ; Schuster, C. M. ; Laube, Bodo ; Schloss, P. ; Schmitt, B. ; Betz, H. (1992)
Glutamate receptors of Drosophila melanogaster: cloning of a kainate-selective subunit expressed in the central nervous system.
In: Proceedings of the National Academy of Sciences of the United States of America, 89 (21)
Artikel, Bibliographie

Müller, M. ; Laube, Bodo ; Burda, H. ; Bruns, V. (1992)
Structure and function of the cochlea in the African mole rat (Cryptomys hottentotus): evidence for a low frequency acoustic fovea.
In: Journal of comparative physiology. A, Sensory, neural, and behavioral physiology, 171 (4)
Artikel, Bibliographie

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