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Molecular cloning and functional expression of a novel rat heart P2X purinoceptor.

Garcia-Guzman, M. and Soto, F. and Laube, Bodo and Stühmer, W. (1996):
Molecular cloning and functional expression of a novel rat heart P2X purinoceptor.
In: FEBS letters, pp. 123-7, 388, (2-3), ISSN 0014-5793, [Article]

Abstract

Here we describe a novel purinergic receptor, the P2X5 receptor, cloned from rat heart. The full-length cDNA encodes a protein 455 amino acids long which shares an overall identity of 40-47% with other members of the P2X purinergic receptor family. P2X5 mRNA transcripts are found predominantly in rat heart but are also present in brain, spinal cord and adrenal gland. Functional expression of the recombinant receptor in HEK-293 cells shows a current that resembles mostly the P2X2 phenotype: the ATP-activated current reveals little agonist desensitization, is not activated by alpha,beta-meATP and is completely blocked by suramin and PPADS.

Item Type: Article
Erschienen: 1996
Creators: Garcia-Guzman, M. and Soto, F. and Laube, Bodo and Stühmer, W.
Title: Molecular cloning and functional expression of a novel rat heart P2X purinoceptor.
Language: English
Abstract:

Here we describe a novel purinergic receptor, the P2X5 receptor, cloned from rat heart. The full-length cDNA encodes a protein 455 amino acids long which shares an overall identity of 40-47% with other members of the P2X purinergic receptor family. P2X5 mRNA transcripts are found predominantly in rat heart but are also present in brain, spinal cord and adrenal gland. Functional expression of the recombinant receptor in HEK-293 cells shows a current that resembles mostly the P2X2 phenotype: the ATP-activated current reveals little agonist desensitization, is not activated by alpha,beta-meATP and is completely blocked by suramin and PPADS.

Journal or Publication Title: FEBS letters
Volume: 388
Number: 2-3
Divisions: 10 Department of Biology
10 Department of Biology > Neurophysiology and Neurosensory Systems
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Date Deposited: 12 Apr 2011 11:16
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