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Number of items: 40.

Friedel, Laura ; Loewer, Alexander (2021):
The guardian's choice: How p53 enables context-specific decision making in individual cells.
In: The FEBS journal, ISSN 1742-4658,
DOI: 10.1111/febs.15767,
[Article]

Philippe, Grégoire J.-B. ; Mittermeier, Anna ; Lawrence, Nicole ; Huang, Yen-Hua ; Condon, Nicholas D. ; Loewer, Alexander ; Craik, David J. ; Henriques, Sónia T. (2021):
Angler Peptides: Macrocyclic Conjugates Inhibit p53:MDM2/X Interactions and Activate Apoptosis in Cancer Cells.
In: ACS chemical biology, 16 (2), pp. 414-428. ISSN 1554-8937,
DOI: 10.1021/acschembio.0c00988,
[Article]

Konrath, Fabian ; Mittermeier, Anna ; Cristiano, Elena ; Wolf, Jana ; Loewer, Alexander (2020):
A systematic approach to decipher crosstalk in the p53 signaling pathway using single cell dynamics.
In: PLoS computational biology, 16 (6), pp. e1007901. ISSN 1553-7358,
DOI: 10.1371/journal.pcbi.1007901,
[Article]

Benary, Manuela ; Bohn, Stefan ; Lüthen, Mareen ; Nolis, Ilias K. ; Blüthgen, Nils ; Loewer, Alexander (2020):
Disentangling Pro-mitotic Signaling during Cell Cycle Progression using Time-Resolved Single-Cell Imaging.
In: Cell reports, 31 (2), p. 107514. ISSN 2211-1247,
DOI: 10.1016/j.celrep.2020.03.078,
[Article]

Jentsch, Marcel ; Snyder, Petra ; Sheng, Caibin ; Cristiano, Elena ; Loewer, Alexander (2020):
p53 dynamics in single cells are temperature-sensitive.
In: Scientific Reports, 10 (1), ISSN 2045-2322,
DOI: 10.25534/tuprints-00011576,
[Article]

Friedrich, Dhana ; Friedel, Laura ; Finzel, Ana ; Herrmann, Andreas ; Preibisch, Stephan ; Loewer, Alexander (2019):
Stochastic transcription in the p53-mediated response to DNA damage is modulated by burst frequency.
In: Molecular systems biology, 15 (12), pp. e9068. ISSN 1744-4292,
DOI: 10.15252/msb.20199068,
[Article]

Philippe, Grégoire J.-B. ; Gaspar, Diana ; Sheng, Caibin ; Huang, Yen-Hua ; Benfield, Aurélie H. ; Condon, Nicholas D. ; Weidmann, Joachim ; Lawrence, Nicole ; Loewer, Alexander ; Castanho, Miguel A. R. B. ; Craik, David J. ; Troeira Henriques, Sónia (2019):
Cell Membrane Composition Drives Selectivity and Toxicity of Designed Cyclic Helix–Loop–Helix Peptides with Cell Penetrating and Tumor Suppressor Properties.
In: ACS Chemical Biology, 14 (9), pp. 2071-2087. ISSN 1554-8929,
DOI: 10.1021/acschembio.9b00593,
[Article]

Sheng, Caibin ; Mendler, Isabella-Hilda ; Rieke, Sara ; Snyder, Petra ; Jentsch, Marc ; Friedrich, Dhana ; Drossel, Barbara ; Loewer, Alexander (2019):
PCNA-Mediated Degradation of p21 Coordinates the DNA Damage Response and Cell Cycle Regulation in Individual Cells.
In: Cell Reports, 27 (1), pp. 47-58.e7. DOI: 10.1016/j.celrep.2019.03.031,
[Article]

Chamiolo, Jasmine ; Fang, Ge‐min ; Hövelmann, Felix ; Friedrich, Dhana ; Knoll, Andrea ; Loewer, Alexander ; Seitz, Oliver (2019):
Comparing Agent‐Based Delivery of DNA and PNA Forced Intercalation (FIT) Probes for Multicolor mRNA Imaging.
In: ChemBioChem, 20 (4), pp. 595-604. ISSN 1439-4227,
DOI: 10.1002/cbic.201800526,
[Article]

Friedrich, Dhana ; Friedel, Laura ; Finzel, Ana ; Herrmann, Andreas ; Preibisch, Stephan ; Loewer, Alexander (2019):
Stochastic transcription in the p53‐mediated response to DNA damage is modulated by burst frequency.
In: Molecular Systems Biology, 15 (12), EMBOpress, e-ISSN 1744-4292,
DOI: 10.25534/tuprints-00011601,
[Article]

Fang, Ge-Min ; Chamiolo, Jasmine ; Kankowski, Svenja ; Hövelmann, Felix ; Friedrich, Dhana ; Loewer, Alexander ; Meier, Jochen C. ; Seitz, Oliver (2018):
A bright FIT-PNA hybridization probe for the hybridization state specific analysis of a C → U RNA edit via FRET in a binary system.
In: Chemical science, 9 (21), pp. 4794-4800. ISSN 2041-6520,
[Article]

Strasen, Jette ; Sarma, Uddipan ; Jentsch, Marcel ; Bohn, Stefan ; Sheng, Caibin ; Horbelt, Daniel ; Knaus, Petra ; Legewie, Stefan ; Loewer, Alexander (2018):
Cell-specific responses to the cytokine TGFβ are determined by variability in protein levels.
In: Molecular systems biology, 14 (1), pp. e7733. ISSN 1744-4292,
[Article]

Batchelor, Eric ; Loewer, Alexander (2017):
Recent progress and open challenges in modeling p53 dynamics in single cells.
In: Current opinion in systems biology, 3, pp. 54-59. ISSN 2452-3100,
[Article]

Mönke, Gregor ; Cristiano, Elena ; Finzel, Ana ; Friedrich, Dhana ; Herzel, Hanspeter ; Falcke, Martin ; Loewer, Alexander (2017):
Excitability in the p53 network mediates robust signaling with tunable activation thresholds in single cells.
In: Scientific Reports, 7, ISSN 2045-2322,
DOI: 10.1038/srep46571,
[Article]

Paek, Andrew L. ; Liu, Julia C. ; Loewer, Alexander ; Forrester, William C. ; Lahav, Galit (2016):
Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing.
In: Cell, 165 (3), pp. 631-42. ISSN 1097-4172,
[Article]

Finzel, Ana ; Grybowski, Andrea ; Strasen, Jette ; Cristiano, Elena ; Loewer, Alexander (2016):
Hyper-activation of ATM upon DNA-PKcs inhibition modulates p53 dynamics and cell fate in response to DNA damage.
In: Molecular biology of the cell, 27 (15), pp. 2360-2367. ISSN 1939-4586,
[Article]

Schrenk-Siemens, Katrin ; Wende, Hagen ; Prato, Vincenzo ; Song, Kun ; Rostock, Charlotte ; Loewer, Alexander ; Utikal, Jochen ; Lewin, Gary R. ; Lechner, Stefan G. ; Siemens, Jan (2015):
PIEZO2 is required for mechanotransduction in human stem cell-derived touch receptors.
In: Nature neuroscience, 18 (1), pp. 10-6. ISSN 1546-1726,
[Article]

Borcherds, Wade ; Theillet, François-Xavier ; Katzer, Andrea ; Finzel, Ana ; Mishall, Katie M. ; Powell, Anne T. ; Wu, Hongwei ; Manieri, Wanda ; Dieterich, Christoph ; Selenko, Philipp ; Loewer, Alexander ; Daughdrill, Gary W. (2014):
Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells.
In: Nature chemical biology, 10 (12), pp. 1000-2. ISSN 1552-4469,
[Article]

González, Erik ; Rother, Marion ; Kerr, Markus C. ; Al-Zeer, Munir A. ; Abu-Lubad, Mohammad ; Kessler, Mirjana ; Brinkmann, Volker ; Loewer, Alexander ; Meyer, Thomas F. (2014):
Chlamydia infection depends on a functional MDM2-p53 axis.
In: Nature communications, 5, p. 5201. ISSN 2041-1723,
[Article]

Schueler, Markus ; Munschauer, Mathias ; Gregersen, Lea Haarup ; Finzel, Ana ; Loewer, Alexander ; Chen, Wei ; Landthaler, Markus ; Dieterich, Christoph (2014):
Differential protein occupancy profiling of the mRNA transcriptome.
In: Genome biology, 15 (1), pp. R15. ISSN 1474-760X,
[Article]

Memczak, Sebastian ; Jens, Marvin ; Elefsinioti, Antigoni ; Torti, Francesca ; Krueger, Janna ; Rybak, Agnieszka ; Maier, Luisa ; Mackowiak, Sebastian D. ; Gregersen, Lea H. ; Munschauer, Mathias ; Loewer, Alexander ; Ziebold, Ulrike ; Landthaler, Markus ; Kocks, Christine ; Le Noble, Ferdinand ; Rajewsky, Nikolaus (2013):
Circular RNAs are a large class of animal RNAs with regulatory potency.
In: Nature, 495 (7441), pp. 333-8. ISSN 1476-4687,
[Article]

Karanam, Ketki ; Loewer, Alexander ; Lahav, Galit (2013):
Dynamics of the DNA damage response: insights from live-cell imaging.
In: Briefings in functional genomics, 12 (2), pp. 109-17. ISSN 2041-2657,
[Article]

Loewer, Alexander ; Karanam, Ketki ; Mock, Caroline ; Lahav, Galit (2013):
The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold.
In: BMC biology, 11, p. 114. ISSN 1741-7007,
[Article]

Orth, James D. ; Loewer, Alexander ; Lahav, Galit ; Mitchison, Timothy J. (2012):
Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction.
In: Molecular biology of the cell, 23 (4), pp. 567-76. ISSN 1939-4586,
[Article]

Karanam, Ketki ; Kafri, Ran ; Loewer, Alexander ; Lahav, Galit (2012):
Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase.
In: Molecular cell, 47 (2), pp. 320-9. ISSN 1097-4164,
[Article]

Purvis, Jeremy E. ; Karhohs, Kyle W. ; Mock, Caroline ; Batchelor, Eric ; Loewer, Alexander ; Lahav, Galit (2012):
p53 dynamics control cell fate.
In: Science (New York, N.Y.), 336 (6087), pp. 1440-4. ISSN 1095-9203,
[Article]

Batchelor, Eric ; Loewer, Alexander ; Mock, Caroline ; Lahav, Galit (2011):
Stimulus-dependent dynamics of p53 in single cells.
In: Molecular systems biology, 7, p. 488. ISSN 1744-4292,
[Article]

Loewer, Alexander ; Lahav, Galit (2011):
We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells.
In: Current opinion in genetics & development, 21 (6), pp. 753-8. ISSN 1879-0380,
[Article]

Loewer, Alexander ; Batchelor, Eric ; Gaglia, Giorgio ; Lahav, Galit (2010):
Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.
In: Cell, 142 (1), pp. 89-100. ISSN 1097-4172,
[Article]

Stempfle, Denise ; Kanwar, Ritu ; Loewer, Alexander ; Fortini, Mark E. ; Merdes, Gunter (2010):
In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.
In: Molecular and cellular biology, 30 (13), pp. 3165-75. ISSN 1098-5549,
[Article]

Toettcher, Jared E. ; Mock, Caroline ; Batchelor, Eric ; Loewer, Alexander ; Lahav, Galit (2010):
A synthetic-natural hybrid oscillator in human cells.
In: Proceedings of the National Academy of Sciences of the United States of America, 107 (39), pp. 17047-52. ISSN 1091-6490,
[Article]

Toettcher, Jared E. ; Loewer, Alexander ; Ostheimer, Gerard J. ; Yaffe, Michael B. ; Tidor, Bruce ; Lahav, Galit (2009):
Distinct mechanisms act in concert to mediate cell cycle arrest.
In: Proceedings of the National Academy of Sciences of the United States of America, 106 (3), pp. 785-90. ISSN 1091-6490,
[Article]

Peshkin, L. ; Goni, J. ; Loewer, Alexander ; Kolluri, R. S. ; Lahav, Galit ; Wall, D. (2009):
Morphology from texture in cytometry.
In: IJTS, 16 (s10), pp. 41-55. [Article]

Batchelor, Eric ; Loewer, Alexander ; Lahav, Galit (2009):
The ups and downs of p53: understanding protein dynamics in single cells.
In: Nature reviews. Cancer, 9 (5), pp. 371-7. ISSN 1474-1768,
[Article]

Batchelor, Eric ; Mock, Caroline S. ; Bhan, Irun ; Loewer, Alexander ; Lahav, Galit (2008):
Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage.
In: Molecular cell, 30 (3), pp. 277-89. ISSN 1097-4164,
[Article]

Rusu, Patricia ; Jansen, Anna ; Soba, Peter ; Kirsch, Joachim ; Loewer, Alexander ; Merdes, Gunter ; Kuan, Yung-Hui ; Jung, Anita ; Beyreuther, Konrad ; Kjaerulff, Ole ; Kins, Stefan (2007):
Axonal accumulation of synaptic markers in APP transgenic Drosophila depends on the NPTY motif and is paralleled by defects in synaptic plasticity.
In: The European journal of neuroscience, 25 (4), pp. 1079-86. ISSN 0953-816X,
[Article]

Soba, Peter ; Eggert, Simone ; Wagner, Katja ; Zentgraf, Hanswalter ; Siehl, Katjuscha ; Kreger, Sylvia ; Loewer, Alexander ; Langer, Andreas ; Merdes, Gunter ; Paro, Renato ; Masters, Colin L. ; Müller, Ulrike ; Kins, Stefan ; Beyreuther, Konrad (2006):
Cell interactions are promoted by transdimerization of APP family members, arranged as homo- or heterocomplexes in synaptic membranes.
In: The EMBO journal, 25 (3), p. 653. ISSN 0261-4189,
[Article]

Loewer, Alexander ; Lahav, Galit (2006):
Cellular conference call: external feedback affects cell-fate decisions.
In: Cell, 124 (6), pp. 1128-30. ISSN 0092-8674,
[Article]

Loewer, Alexander ; Soba, Peter ; Beyreuther, Konrad ; Paro, Renato ; Merdes, Gunter (2004):
Cell-type-specific processing of the amyloid precursor protein by Presenilin during Drosophila development.
In: EMBO reports, 5 (4), pp. 405-11. ISSN 1469-221X,
[Article]

Merdes, Gunter ; Soba, Peter ; Loewer, Alexander ; Bilic, Michaela V. ; Beyreuther, Konrad ; Paro, Renato (2004):
Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila.
In: The EMBO journal, 23 (20), pp. 4082-95. ISSN 0261-4189,
[Article]

This list was generated on Sat Oct 16 05:40:01 2021 CEST.