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Recent progress and open challenges in modeling p53 dynamics in single cells.

Batchelor, Eric and Loewer, Alexander (2017):
Recent progress and open challenges in modeling p53 dynamics in single cells.
In: Current opinion in systems biology, 3, pp. 54-59. ISSN 2452-3100,
[Article]

Abstract

In mammalian cells, the tumor suppressor p53 is activated upon a variety of cellular stresses and ensures an appropriate response ranging from arrest and repair to the induction of senescence and apoptosis. Quantitative measurements in individual living cells showed stimulus-dependent dynamics of p53 accumulation upon stress induction. Due to the complexity of the underlying biochemical interactions, mathematical models were indispensable for understanding the topology of the network regulating p53 dynamics. Recent work provides furhter insights into the causes of heterogeneous responses in individual cells, the rewiring of the network in response to different inputs and the role of the downstream processes in determining the cellular fate upon stress.

Item Type: Article
Erschienen: 2017
Creators: Batchelor, Eric and Loewer, Alexander
Title: Recent progress and open challenges in modeling p53 dynamics in single cells.
Language: English
Abstract:

In mammalian cells, the tumor suppressor p53 is activated upon a variety of cellular stresses and ensures an appropriate response ranging from arrest and repair to the induction of senescence and apoptosis. Quantitative measurements in individual living cells showed stimulus-dependent dynamics of p53 accumulation upon stress induction. Due to the complexity of the underlying biochemical interactions, mathematical models were indispensable for understanding the topology of the network regulating p53 dynamics. Recent work provides furhter insights into the causes of heterogeneous responses in individual cells, the rewiring of the network in response to different inputs and the role of the downstream processes in determining the cellular fate upon stress.

Journal or Publication Title: Current opinion in systems biology
Journal volume: 3
Divisions: 10 Department of Biology
10 Department of Biology > Systems Biology of the Stress Response
Date Deposited: 01 Nov 2017 09:49
Identification Number: pmid:29062976
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