TU Darmstadt / ULB / TUbiblio

Cell-type-specific processing of the amyloid precursor protein by Presenilin during Drosophila development.

Loewer, Alexander and Soba, Peter and Beyreuther, Konrad and Paro, Renato and Merdes, Gunter (2004):
Cell-type-specific processing of the amyloid precursor protein by Presenilin during Drosophila development.
In: EMBO reports, 5 (4), pp. 405-11. ISSN 1469-221X,
[Article]

Abstract

The cleavage of proteins within their transmembrane domain by Presenilin (PS) has an important role in different signalling pathways and in Alzheimer's disease. Nevertheless, not much is known about the regulation of PS activity. It has been suggested that substrate recognition by the PS complex depends only on the size of the extracellular domain independent of the amino-acid sequence and that PS activity is constitutive in all cells that express the minimal components of the complex. We report here the development of an in vivo reporter system that allowed us to analyse the processing of human amyloid precursor protein (APP) and the Notch receptor tissue specifically during Drosophila development in the living organism. Using this system, we demonstrate differences between APP and Notch processing and show that PS-mediated cleavage of APP can be regulated in different cell types independent of the size of the extracellular domain.

Item Type: Article
Erschienen: 2004
Creators: Loewer, Alexander and Soba, Peter and Beyreuther, Konrad and Paro, Renato and Merdes, Gunter
Title: Cell-type-specific processing of the amyloid precursor protein by Presenilin during Drosophila development.
Language: English
Abstract:

The cleavage of proteins within their transmembrane domain by Presenilin (PS) has an important role in different signalling pathways and in Alzheimer's disease. Nevertheless, not much is known about the regulation of PS activity. It has been suggested that substrate recognition by the PS complex depends only on the size of the extracellular domain independent of the amino-acid sequence and that PS activity is constitutive in all cells that express the minimal components of the complex. We report here the development of an in vivo reporter system that allowed us to analyse the processing of human amyloid precursor protein (APP) and the Notch receptor tissue specifically during Drosophila development in the living organism. Using this system, we demonstrate differences between APP and Notch processing and show that PS-mediated cleavage of APP can be regulated in different cell types independent of the size of the extracellular domain.

Journal or Publication Title: EMBO reports
Journal volume: 5
Number: 4
Divisions: 10 Department of Biology
10 Department of Biology > Systems Biology of the Stress Response
Date Deposited: 02 Sep 2015 09:04
Export:
Suche nach Titel in: TUfind oder in Google
Send an inquiry Send an inquiry

Options (only for editors)
Show editorial Details Show editorial Details