Loewer, Alexander ; Lahav, Galit (2011)
We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells.
In: Current opinion in genetics & development, 21 (6)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
The human body is formed by trillions of individual cells. These cells work together with remarkable precision, first forming an adult organism out of a single fertilized egg, and then keeping the organism alive and functional for decades. To achieve this precision, one would assume that each individual cell reacts in a reliable, reproducible way to a given input, faithfully executing the required task. However, a growing number of studies investigating cellular processes on the level of single cells revealed large heterogeneity even among genetically identical cells of the same cell type. Here we discuss the sources of heterogeneity in mammalian systems; how cells ensure reliable processing of information despite fluctuations in their molecular components; and what could be the benefit of cell-to-cell variability for mammalian cells.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2011 |
| Autor(en): | Loewer, Alexander ; Lahav, Galit |
| Art des Eintrags: | Bibliographie |
| Titel: | We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells. |
| Sprache: | Englisch |
| Publikationsjahr: | 2011 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Current opinion in genetics & development |
| Jahrgang/Volume einer Zeitschrift: | 21 |
| (Heft-)Nummer: | 6 |
| Kurzbeschreibung (Abstract): | The human body is formed by trillions of individual cells. These cells work together with remarkable precision, first forming an adult organism out of a single fertilized egg, and then keeping the organism alive and functional for decades. To achieve this precision, one would assume that each individual cell reacts in a reliable, reproducible way to a given input, faithfully executing the required task. However, a growing number of studies investigating cellular processes on the level of single cells revealed large heterogeneity even among genetically identical cells of the same cell type. Here we discuss the sources of heterogeneity in mammalian systems; how cells ensure reliable processing of information despite fluctuations in their molecular components; and what could be the benefit of cell-to-cell variability for mammalian cells. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > Systems Biology of the Stress Response |
| Hinterlegungsdatum: | 02 Sep 2015 08:49 |
| Letzte Änderung: | 02 Sep 2015 08:49 |
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