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We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells.

Loewer, Alexander ; Lahav, Galit :
We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells.
In: Current opinion in genetics & development, 21 (6) S. 753-8. ISSN 1879-0380
[Artikel] , (2011)

Kurzbeschreibung (Abstract)

The human body is formed by trillions of individual cells. These cells work together with remarkable precision, first forming an adult organism out of a single fertilized egg, and then keeping the organism alive and functional for decades. To achieve this precision, one would assume that each individual cell reacts in a reliable, reproducible way to a given input, faithfully executing the required task. However, a growing number of studies investigating cellular processes on the level of single cells revealed large heterogeneity even among genetically identical cells of the same cell type. Here we discuss the sources of heterogeneity in mammalian systems; how cells ensure reliable processing of information despite fluctuations in their molecular components; and what could be the benefit of cell-to-cell variability for mammalian cells.

Typ des Eintrags: Artikel
Erschienen: 2011
Autor(en): Loewer, Alexander ; Lahav, Galit
Titel: We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells.
Sprache: Englisch
Kurzbeschreibung (Abstract):

The human body is formed by trillions of individual cells. These cells work together with remarkable precision, first forming an adult organism out of a single fertilized egg, and then keeping the organism alive and functional for decades. To achieve this precision, one would assume that each individual cell reacts in a reliable, reproducible way to a given input, faithfully executing the required task. However, a growing number of studies investigating cellular processes on the level of single cells revealed large heterogeneity even among genetically identical cells of the same cell type. Here we discuss the sources of heterogeneity in mammalian systems; how cells ensure reliable processing of information despite fluctuations in their molecular components; and what could be the benefit of cell-to-cell variability for mammalian cells.

Titel der Zeitschrift, Zeitung oder Schriftenreihe: Current opinion in genetics & development
Band: 21
(Heft-)Nummer: 6
Fachbereich(e)/-gebiet(e): 10 Fachbereich Biologie
10 Fachbereich Biologie > Systems Biology of the Stress Response
Hinterlegungsdatum: 02 Sep 2015 08:49
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