TU Darmstadt / ULB / TUbiblio

p53 dynamics control cell fate.

Purvis, Jeremy E. and Karhohs, Kyle W. and Mock, Caroline and Batchelor, Eric and Loewer, Alexander and Lahav, Galit (2012):
p53 dynamics control cell fate.
In: Science (New York, N.Y.), 336 (6087), pp. 1440-4. ISSN 1095-9203,
[Article]

Abstract

Cells transmit information through molecular signals that often show complex dynamical patterns. The dynamic behavior of the tumor suppressor p53 varies depending on the stimulus; in response to double-strand DNA breaks, it shows a series of repeated pulses. Using a computational model, we identified a sequence of precisely timed drug additions that alter p53 pulses to instead produce a sustained p53 response. This leads to the expression of a different set of downstream genes and also alters cell fate: Cells that experience p53 pulses recover from DNA damage, whereas cells exposed to sustained p53 signaling frequently undergo senescence. Our results show that protein dynamics can be an important part of a signal, directly influencing cellular fate decisions.

Item Type: Article
Erschienen: 2012
Creators: Purvis, Jeremy E. and Karhohs, Kyle W. and Mock, Caroline and Batchelor, Eric and Loewer, Alexander and Lahav, Galit
Title: p53 dynamics control cell fate.
Language: English
Abstract:

Cells transmit information through molecular signals that often show complex dynamical patterns. The dynamic behavior of the tumor suppressor p53 varies depending on the stimulus; in response to double-strand DNA breaks, it shows a series of repeated pulses. Using a computational model, we identified a sequence of precisely timed drug additions that alter p53 pulses to instead produce a sustained p53 response. This leads to the expression of a different set of downstream genes and also alters cell fate: Cells that experience p53 pulses recover from DNA damage, whereas cells exposed to sustained p53 signaling frequently undergo senescence. Our results show that protein dynamics can be an important part of a signal, directly influencing cellular fate decisions.

Journal or Publication Title: Science (New York, N.Y.)
Journal volume: 336
Number: 6087
Divisions: 10 Department of Biology
10 Department of Biology > Systems Biology of the Stress Response
Date Deposited: 02 Sep 2015 08:44
Export:
Suche nach Titel in: TUfind oder in Google
Send an inquiry Send an inquiry

Options (only for editors)
Show editorial Details Show editorial Details