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Dynamics of the DNA damage response: insights from live-cell imaging.

Karanam, Ketki ; Loewer, Alexander ; Lahav, Galit :
Dynamics of the DNA damage response: insights from live-cell imaging.
In: Briefings in functional genomics, 12 (2) S. 109-17. ISSN 2041-2657
[Artikel] , (2013)

Kurzbeschreibung (Abstract)

All organisms have to safeguard the integrity of their genome to prevent malfunctioning and oncogenic transformation. Sophisticated DNA damage response mechanisms have evolved to detect and repair genomic lesions. With the emergence of live-cell microscopy of individual cells, we now begin to appreciate the complex spatiotemporal kinetics of the DNA damage response and can address the causes and consequences of the heterogeneity in the responses of genetically identical cells. Here, we highlight key discoveries where live-cell imaging has provided unprecedented insights into how cells respond to DNA double-strand breaks and discuss the main challenges and promises in using this technique.

Typ des Eintrags: Artikel
Erschienen: 2013
Autor(en): Karanam, Ketki ; Loewer, Alexander ; Lahav, Galit
Titel: Dynamics of the DNA damage response: insights from live-cell imaging.
Sprache: Englisch
Kurzbeschreibung (Abstract):

All organisms have to safeguard the integrity of their genome to prevent malfunctioning and oncogenic transformation. Sophisticated DNA damage response mechanisms have evolved to detect and repair genomic lesions. With the emergence of live-cell microscopy of individual cells, we now begin to appreciate the complex spatiotemporal kinetics of the DNA damage response and can address the causes and consequences of the heterogeneity in the responses of genetically identical cells. Here, we highlight key discoveries where live-cell imaging has provided unprecedented insights into how cells respond to DNA double-strand breaks and discuss the main challenges and promises in using this technique.

Titel der Zeitschrift, Zeitung oder Schriftenreihe: Briefings in functional genomics
Band: 12
(Heft-)Nummer: 2
Fachbereich(e)/-gebiet(e): 10 Fachbereich Biologie
10 Fachbereich Biologie > Systems Biology of the Stress Response
Hinterlegungsdatum: 02 Sep 2015 08:38
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