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Dynamics of the DNA damage response: insights from live-cell imaging.

Karanam, Ketki and Loewer, Alexander and Lahav, Galit (2013):
Dynamics of the DNA damage response: insights from live-cell imaging.
In: Briefings in functional genomics, 12 (2), pp. 109-17. ISSN 2041-2657,
[Article]

Abstract

All organisms have to safeguard the integrity of their genome to prevent malfunctioning and oncogenic transformation. Sophisticated DNA damage response mechanisms have evolved to detect and repair genomic lesions. With the emergence of live-cell microscopy of individual cells, we now begin to appreciate the complex spatiotemporal kinetics of the DNA damage response and can address the causes and consequences of the heterogeneity in the responses of genetically identical cells. Here, we highlight key discoveries where live-cell imaging has provided unprecedented insights into how cells respond to DNA double-strand breaks and discuss the main challenges and promises in using this technique.

Item Type: Article
Erschienen: 2013
Creators: Karanam, Ketki and Loewer, Alexander and Lahav, Galit
Title: Dynamics of the DNA damage response: insights from live-cell imaging.
Language: English
Abstract:

All organisms have to safeguard the integrity of their genome to prevent malfunctioning and oncogenic transformation. Sophisticated DNA damage response mechanisms have evolved to detect and repair genomic lesions. With the emergence of live-cell microscopy of individual cells, we now begin to appreciate the complex spatiotemporal kinetics of the DNA damage response and can address the causes and consequences of the heterogeneity in the responses of genetically identical cells. Here, we highlight key discoveries where live-cell imaging has provided unprecedented insights into how cells respond to DNA double-strand breaks and discuss the main challenges and promises in using this technique.

Journal or Publication Title: Briefings in functional genomics
Journal volume: 12
Number: 2
Divisions: 10 Department of Biology
10 Department of Biology > Systems Biology of the Stress Response
Date Deposited: 02 Sep 2015 08:38
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