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A systematic approach to decipher crosstalk in the p53 signaling pathway using single cell dynamics.
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p53 dynamics in single cells are temperature-sensitive.
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Excitability in the p53 network mediates robust signaling with tunable activation thresholds in single cells.
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Finzel, Ana and Grybowski, Andrea and Strasen, Jette and Cristiano, Elena and Loewer, Alexander (2016):
Hyper-activation of ATM upon DNA-PKcs inhibition modulates p53 dynamics and cell fate in response to DNA damage.
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