Batchelor, Eric and Loewer, Alexander and Lahav, Galit (2009):
The ups and downs of p53: understanding protein dynamics in single cells.
In: Nature reviews. Cancer, 9 (5), pp. 371-7. ISSN 1474-1768,
[Article]
Abstract
Cells living in a complex environment must constantly detect, process and appropriately respond to changing signals. Therefore, all cellular information processing is dynamic in nature. As a consequence, understanding the process of signal transduction often requires detailed quantitative analysis of dynamic behaviours. Here, we focus on the oscillatory dynamics of the tumour suppressor protein p53 as a model for studying protein dynamics in single cells to better understand its regulation and function.
| Item Type: | Article |
|---|---|
| Erschienen: | 2009 |
| Creators: | Batchelor, Eric and Loewer, Alexander and Lahav, Galit |
| Title: | The ups and downs of p53: understanding protein dynamics in single cells. |
| Language: | English |
| Abstract: | Cells living in a complex environment must constantly detect, process and appropriately respond to changing signals. Therefore, all cellular information processing is dynamic in nature. As a consequence, understanding the process of signal transduction often requires detailed quantitative analysis of dynamic behaviours. Here, we focus on the oscillatory dynamics of the tumour suppressor protein p53 as a model for studying protein dynamics in single cells to better understand its regulation and function. |
| Journal or Publication Title: | Nature reviews. Cancer |
| Journal volume: | 9 |
| Number: | 5 |
| Divisions: | 10 Department of Biology 10 Department of Biology > Systems Biology of the Stress Response |
| Date Deposited: | 02 Sep 2015 08:55 |
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