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The ups and downs of p53: understanding protein dynamics in single cells.

Batchelor, Eric and Loewer, Alexander and Lahav, Galit (2009):
The ups and downs of p53: understanding protein dynamics in single cells.
In: Nature reviews. Cancer, 9 (5), pp. 371-7. ISSN 1474-1768,
[Article]

Abstract

Cells living in a complex environment must constantly detect, process and appropriately respond to changing signals. Therefore, all cellular information processing is dynamic in nature. As a consequence, understanding the process of signal transduction often requires detailed quantitative analysis of dynamic behaviours. Here, we focus on the oscillatory dynamics of the tumour suppressor protein p53 as a model for studying protein dynamics in single cells to better understand its regulation and function.

Item Type: Article
Erschienen: 2009
Creators: Batchelor, Eric and Loewer, Alexander and Lahav, Galit
Title: The ups and downs of p53: understanding protein dynamics in single cells.
Language: English
Abstract:

Cells living in a complex environment must constantly detect, process and appropriately respond to changing signals. Therefore, all cellular information processing is dynamic in nature. As a consequence, understanding the process of signal transduction often requires detailed quantitative analysis of dynamic behaviours. Here, we focus on the oscillatory dynamics of the tumour suppressor protein p53 as a model for studying protein dynamics in single cells to better understand its regulation and function.

Journal or Publication Title: Nature reviews. Cancer
Journal volume: 9
Number: 5
Divisions: 10 Department of Biology
10 Department of Biology > Systems Biology of the Stress Response
Date Deposited: 02 Sep 2015 08:55
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