Batchelor, Eric ; Loewer, Alexander ; Lahav, Galit
:
The ups and downs of p53: understanding protein dynamics in single cells.
In:
Nature reviews. Cancer, 9
(5)
pp. 371-7.
ISSN 1474-1768
[Artikel], (2009)
Kurzbeschreibung (Abstract)
Cells living in a complex environment must constantly detect, process and appropriately respond to changing signals. Therefore, all cellular information processing is dynamic in nature. As a consequence, understanding the process of signal transduction often requires detailed quantitative analysis of dynamic behaviours. Here, we focus on the oscillatory dynamics of the tumour suppressor protein p53 as a model for studying protein dynamics in single cells to better understand its regulation and function.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2009 |
| Autor(en): | Batchelor, Eric ; Loewer, Alexander ; Lahav, Galit |
| Titel: | The ups and downs of p53: understanding protein dynamics in single cells. |
| Sprache: | Englisch |
| Kurzbeschreibung (Abstract): | Cells living in a complex environment must constantly detect, process and appropriately respond to changing signals. Therefore, all cellular information processing is dynamic in nature. As a consequence, understanding the process of signal transduction often requires detailed quantitative analysis of dynamic behaviours. Here, we focus on the oscillatory dynamics of the tumour suppressor protein p53 as a model for studying protein dynamics in single cells to better understand its regulation and function. |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Nature reviews. Cancer |
| Band: | 9 |
| (Heft-)Nummer: | 5 |
| Fachbereich(e)/-gebiet(e): | Fachbereich Biologie, Biology Fachbereich Biologie, Biology > Molekularbiologie der Stressantwort |
| Hinterlegungsdatum: | 02 Sep 2015 08:55 |
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