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The ups and downs of p53: understanding protein dynamics in single cells.

Batchelor, Eric ; Loewer, Alexander ; Lahav, Galit :
The ups and downs of p53: understanding protein dynamics in single cells.
In: Nature reviews. Cancer, 9 (5) pp. 371-7. ISSN 1474-1768
[Artikel], (2009)

Kurzbeschreibung (Abstract)

Cells living in a complex environment must constantly detect, process and appropriately respond to changing signals. Therefore, all cellular information processing is dynamic in nature. As a consequence, understanding the process of signal transduction often requires detailed quantitative analysis of dynamic behaviours. Here, we focus on the oscillatory dynamics of the tumour suppressor protein p53 as a model for studying protein dynamics in single cells to better understand its regulation and function.

Typ des Eintrags: Artikel
Erschienen: 2009
Autor(en): Batchelor, Eric ; Loewer, Alexander ; Lahav, Galit
Titel: The ups and downs of p53: understanding protein dynamics in single cells.
Sprache: Englisch
Kurzbeschreibung (Abstract):

Cells living in a complex environment must constantly detect, process and appropriately respond to changing signals. Therefore, all cellular information processing is dynamic in nature. As a consequence, understanding the process of signal transduction often requires detailed quantitative analysis of dynamic behaviours. Here, we focus on the oscillatory dynamics of the tumour suppressor protein p53 as a model for studying protein dynamics in single cells to better understand its regulation and function.

Titel der Zeitschrift, Zeitung oder Schriftenreihe: Nature reviews. Cancer
Band: 9
(Heft-)Nummer: 5
Fachbereich(e)/-gebiet(e): Fachbereich Biologie, Biology
Fachbereich Biologie, Biology > Molekularbiologie der Stressantwort
Hinterlegungsdatum: 02 Sep 2015 08:55
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