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Einträge mit Organisationseinheit "10 Fachbereich Biologie > Genregulation und RNA-Therapeutika"

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Anzahl der Einträge auf dieser Ebene: 68.

A

Adler, Annette ; Forster, Nicole ; Homann, Matthias ; Göringer, H. Ulrich :
Post-SELEX chemical optimization of a trypanosome-specific RNA aptamer.
In: Combinatorial chemistry & high throughput screening, 11 (1) pp. 16-23. ISSN 1386-2073
[Artikel], (2008)

Allen, T. E. ; Heidmann, S. ; Reed, R. ; Myler, P. J. ; Göringer, H. Ulrich ; Stuart, K. D. :
Association of guide RNA binding protein gBP21 with active RNA editing complexes in Trypanosoma brucei.
In: Molecular and cellular biology, 18 (10) pp. 6014-22. ISSN 0270-7306
[Artikel], (1998)

B

Bohm, Cordula ; Katari, Venkata Subbaraju ; Brecht, Michael ; Göringer, H. Ulrich :
Trypanosoma brucei 20S editosomes have one RNA substrate-binding site and execute RNA unwinding activity.
In: The Journal of biological chemistry, 287 (31) pp. 26268-26277. ISSN 1083-351X
[Artikel], (2012)

Best, Alexander ; Handoko, Lusy ; Schlüter, Elke ; Göringer, H. Ulrich :
In vitro synthesized small interfering RNAs elicit RNA interference in african trypanosomes: an in vitro and in vivo analysis.
In: The Journal of biological chemistry, 280 (21) pp. 20573-9. ISSN 0021-9258
[Artikel], (2005)

Brecht, Michael ; Niemann, Moritz ; Schlüter, Elke ; Müller, Ulrich F. ; Stuart, Ken ; Göringer, H. Ulrich :
TbMP42, a protein component of the RNA editing complex in African trypanosomes, has endo-exoribonuclease activity.
In: Molecular cell, 17 (5) pp. 621-30. ISSN 1097-2765
[Artikel], (2005)

G

Göringer, H. Ulrich :
Parasite-specific aptamers as biosynthetic reagents and potential pharmaceuticals.
In: Trends in parasitology, 28 (3) pp. 106-113. ISSN 1471-5007
[Artikel], (2012)

Göringer, H. Ulrich :
'Gestalt,' Composition and Function of the Trypanosoma brucei Editosome.
In: Annual review of microbiology, 66 pp. 65-82. ISSN 1545-3251
[Artikel], (2012)

Göringer, H. Ulrich ; Katari, Venkata Subbaraju ; Böhm, Cordula :
The structural landscape of native editosomes in African trypanosomes.
In: Wiley interdisciplinary reviews. RNA, 2 (3) pp. 395-407. ISSN 1757-7012
[Artikel], (2011)

Göringer, H. Ulrich ; Stark, Holger ; Böhm, Cordula ; Sander, Bjoern ; Golas, Monika M. :
Three-dimensional reconstruction of Trypanosoma brucei editosomes using single-particle electron microscopy.
In: Methods in molecular biology (Clifton, N.J.), 718 pp. 3-22. ISSN 1940-6029
[Artikel], (2011)

Golas, Monika M. ; Böhm, Cordula ; Sander, Bjoern ; Effenberger, Kerstin ; Brecht, Michael ; Stark, Holger ; Göringer, H. Ulrich :
Snapshots of the RNA editing machine in trypanosomes captured at different assembly stages in vivo.
In: The EMBO journal, 28 (6) pp. 766-78. ISSN 1460-2075
[Artikel], (2009)

Göringer, H. Ulrich ; Homann, M. ; Zacharias, M. ; Adler, A. :
RNA aptamers as potential pharmaceuticals against infections with African trypanosomes.
In: Handbook of experimental pharmacology (173) pp. 375-93. ISSN 0171-2004
[Artikel], (2006)

Göringer, H. Ulrich ; Homann, Matthias ; Lorger, Mihaela :
In vitro selection of high-affinity nucleic acid ligands to parasite target molecules.
In: International journal for parasitology, 33 (12) pp. 1309-17. ISSN 0020-7519
[Artikel], (2003)

Göringer, H. Ulrich ; Koslowsky, D. J. ; Morales, T. H. ; Stuart, K. :
The formation of mitochondrial ribonucleoprotein complexes involving guide RNA molecules in Trypanosoma brucei.
In: Proceedings of the National Academy of Sciences of the United States of America, 91 (5) pp. 1776-80. ISSN 0027-8424
[Artikel], (1994)

Göringer, H. Ulrich ; Hijazi, K. A. ; Murgola, E. J. ; Dahlberg, A. E. :
Mutations in 16S rRNA that affect UGA (stop codon)-directed translation termination.
In: Proceedings of the National Academy of Sciences of the United States of America, 88 (15) pp. 6603-7. ISSN 0027-8424
[Artikel], (1991)

Göringer, H. Ulrich ; Wagner, R. :
5S RNA structure and function.
In: Methods in enzymology, 164 pp. 721-47. ISSN 0076-6879
[Artikel], (1988)

Göringer, H. Ulrich ; Wagner, R. :
Does 5S RNA from E. coli have a pseudoknotted structure?
In: Nucleic acids research, 14 (18) pp. 7473-85. ISSN 0305-1048
[Artikel], (1986)

Göringer, H. Ulrich ; Wagner, R. :
Construction and functional analysis of ribosomal 5S RNA from Escherichia coli with single base changes in the ribosomal protein binding sites.
In: Biological chemistry Hoppe-Seyler, 367 (8) pp. 769-80. ISSN 0177-3593
[Artikel], (1986)

Göringer, H. Ulrich ; Szymkowiak, C. ; Wagner, R. :
Escherichia coli 5S RNA A and B conformers. Characterisation by enzymatic and chemical methods.
In: European journal of biochemistry / FEBS, 144 (1) pp. 25-34. ISSN 0014-2956
[Artikel], (1984)

Göringer, H. Ulrich ; Wagner, R. ; Jacob, W. F. ; Dahlberg, A. E. ; Zwieb, C. :
Oligonucleotide directed mutagenesis of Escherichia coli 5S ribosomal RNA: construction of mutant and structural analysis.
In: Nucleic acids research, 12 (18) pp. 6935-50. ISSN 0305-1048
[Artikel], (1984)

Göringer, H. Ulrich ; Bertram, S. ; Wagner, R. :
The effect of tRNA binding on the structure of 5 S RNA in Escherichia coli. A chemical modification study.
In: The Journal of biological chemistry, 259 (1) pp. 491-6. ISSN 0021-9258
[Artikel], (1984)

H

Hofmeyer, Thomas ; Bulani, Siyavuya Ishmael ; Grzeschik, Julius ; Krah, Simon ; Glotzbach, Bernhard ; Uth, Christina ; Avrutina, Olga ; Brecht, Michael ; Göringer, H. Ulrich ; van Zyl, Petrus ; Kolmar, Harald :
Protein Production in Yarrowia lipolytica Via Fusion to the Secreted Lipase Lip2p.
In: Molecular biotechnology, 56 (1) pp. 79-80. ISSN 1559-0305
[Artikel], (2014)

Homann, Matthias ; Lorger, Mihaela ; Engstler, Markus ; Zacharias, Martin ; Göringer, H. Ulrich :
Serum-stable RNA aptamers to an invariant surface domain of live African trypanosomes.
In: Combinatorial chemistry & high throughput screening, 9 (7) pp. 491-9. ISSN 1386-2073
[Artikel], (2006)

Homann, M. ; Göringer, H. Ulrich :
Uptake and intracellular transport of RNA aptamers in African trypanosomes suggest therapeutic "piggy-back" approach.
In: Bioorganic & medicinal chemistry, 9 (10) pp. 2571-80. ISSN 0968-0896
[Artikel], (2001)

Homann, M. ; Göringer, H. Ulrich :
Combinatorial selection of high affinity RNA ligands to live African trypanosomes.
In: Nucleic acids research, 27 (9) pp. 2006-14. ISSN 0305-1048
[Artikel], (1999)

Hinz, S. ; Göringer, H. Ulrich :
The guide RNA database (3.0).
In: Nucleic acids research, 27 (1) p. 168. ISSN 0305-1048
[Artikel], (1999)

Hermann, T. ; Schmid, B. ; Heumann, H. ; Göringer, H. Ulrich :
A three-dimensional working model for a guide RNA from Trypanosoma brucei.
In: Nucleic acids research, 25 (12) pp. 2311-8. ISSN 0305-1048
[Artikel], (1997)

Hänfler, A. ; Kleuvers, B. ; Göringer, H. Ulrich :
The involvement of base 1054 in 16S rRNA for UGA stop codon dependent translational termination.
In: Nucleic acids research, 18 (19) pp. 5625-32. ISSN 0305-1048
[Artikel], (1990)

K

Katari, Venkata Subbaraju :
Trypanosoma brucei editosomes have a single, bifunctional reaction center - Evidence for a non-collisional reaction mechanism.
[Online-Edition: http://tuprints.ulb.tu-darmstadt.de/3738]
TU Darmstadt
[Dissertation], (2013)

Kruse, Elisabeth ; Voigt, Christin ; Leeder, W.-Matthias ; Göringer, H. Ulrich :
RNA helicases involved in U-insertion/deletion-type RNA editing.
In: Biochimica et biophysica acta - Gene regulation mechanisms, 1829 (8) pp. 835-841. ISSN 0006-3002
[Artikel], (2013)

Katari, Venkata Subbaraju ; van Esdonk, Lea ; Göringer, H. Ulrich :
Molecular crowding inhibits u-insertion/deletion RNA editing in vitro: consequences for the in vivo reaction.
In: PloS one, 8 (12) e83796. ISSN 1932-6203
[Artikel], (2013)

Kölzer, Michael ; Weitzel, Kerstin ; Göringer, H. Ulrich ; Thines, Eckhard ; Opatz, Till :
Synthesis of bioactive 2-aza-analogues of ipecac and alangium alkaloids.
In: ChemMedChem, 5 (9) pp. 1456-64. ISSN 1860-7187
[Artikel], (2010)

König, Julian ; Julius, Christian ; Baumann, Sebastian ; Homann, Matthias ; Göringer, H. Ulrich ; Feldbrügge, Michael :
Combining SELEX and the yeast three-hybrid system for in vivo selection and classification of RNA aptamers.
In: RNA (New York, N.Y.), 13 (4) pp. 614-22. ISSN 1355-8382
[Artikel], (2007)

Köller, J. ; Müller, U. F. ; Schmid, B. ; Missel, A. ; Kruft, V. ; Stuart, K. ; Göringer, H. Ulrich :
Trypanosoma brucei gBP21. An arginine-rich mitochondrial protein that binds to guide RNA with high affinity.
In: The Journal of biological chemistry, 272 (6) pp. 3749-57. ISSN 0021-9258
[Artikel], (1997)

Köller, J. ; Nörskau, G. ; Paul, A. S. ; Stuart, K. ; Göringer, H. Ulrich :
Different Trypanosoma brucei guide RNA molecules associate with an identical complement of mitochondrial proteins in vitro.
In: Nucleic acids research, 22 (11) pp. 1988-95. ISSN 0305-1048
[Artikel], (1994)

Koslowsky, D. J. ; Göringer, H. Ulrich ; Morales, T. H. ; Stuart, K. :
In vitro guide RNA/mRNA chimaera formation in Trypanosoma brucei RNA editing.
In: Nature, 356 (6372) pp. 807-9. ISSN 0028-0836
[Artikel], (1992)

L

Leeder, W-Matthias ; Voskuhl, Stephan ; Göringer, H. Ulrich :
The 2D Structure of the T. brucei Preedited RPS12 mRNA Is Not Affected by Macromolecular Crowding.
In: Journal of nucleic acids, 2017 p. 6067345. ISSN 2090-0201
[Artikel], (2017)

Leeder, W.-Matthias ; Voigt, Christin ; Brecht, Michael ; Göringer, H. Ulrich :
The RNA chaperone activity of the Trypanosoma brucei editosome raises the dynamic of bound pre-mRNAs.
In: Scientific reports, 6 p. 19309. ISSN 2045-2322
[Artikel], (2016)

Leeder, W.-Matthias ; Hummel, Niklas F. C. ; Göringer, H. Ulrich :
Multiple G-quartet structures in pre-edited mRNAs suggest evolutionary driving force for RNA editing in trypanosomes.
In: Scientific reports, 6 p. 29810. ISSN 2045-2322
[Artikel], (2016)

Leeder, W.-Matthias ; Reuss, Andreas J. ; Brecht, Michael ; Kratz, Katja ; Wachtveitl, Josef ; Göringer, H. Ulrich :
Charge Reduction and Thermodynamic Stabilization of Substrate RNAs Inhibit RNA Editing.
In: PloS one, 10 (3) e0118940. ISSN 1932-6203
[Artikel], (2015)

Lorger, Mihaela ; Engstler, Markus ; Homann, Matthias ; Göringer, H. Ulrich :
Targeting the variable surface of African trypanosomes with variant surface glycoprotein-specific, serum-stable RNA aptamers.
In: Eukaryotic cell, 2 (1) pp. 84-94. ISSN 1535-9778
[Artikel], (2003)

Lambert, L. ; Müller, U. F. ; Souza, A. E. ; Göringer, H. Ulrich :
The involvement of gRNA-binding protein gBP21 in RNA editing-an in vitro and in vivo analysis.
In: Nucleic acids research, 27 (6) pp. 1429-36. ISSN 0305-1048
[Artikel], (1999)

M

Madej, Monika J. ; Niemann, Moritz ; Hüttenhofer, Alexander ; Göringer, H. Ulrich :
Identification of novel guide RNAs from the mitochondria of Trypanosoma brucei.
In: RNA biology, 5 (2) pp. 84-91. ISSN 1555-8584
[Artikel], (2008)

Müller, Ulrich F. ; Göringer, H. Ulrich :
Mechanism of the gBP21-mediated RNA/RNA annealing reaction: matchmaking and charge reduction.
In: Nucleic acids research, 30 (2) pp. 447-55. ISSN 1362-4962
[Artikel], (2002)

Müller, U. F. ; Lambert, L. ; Göringer, H. Ulrich :
Annealing of RNA editing substrates facilitated by guide RNA-binding protein gBP21.
In: The EMBO journal, 20 (6) pp. 1394-404. ISSN 0261-4189
[Artikel], (2001)

Missel, A. ; Lambert, L. ; Nörskau, G. ; Göringer, H. Ulrich :
DEAD-box protein HEL64 from Trypanosoma brucei: subcellular localization and gene knockout analysis.
In: Parasitology research, 85 (4) pp. 324-30. ISSN 0932-0113
[Artikel], (1999)

Missel, A. ; Souza, A. E. ; Nörskau, G. ; Göringer, H. Ulrich :
Disruption of a gene encoding a novel mitochondrial DEAD-box protein in Trypanosoma brucei affects edited mRNAs.
In: Molecular and cellular biology, 17 (9) pp. 4895-903. ISSN 0270-7306
[Artikel], (1997)

Missel, A. ; Nörskau, G. ; Shu, H. H. ; Göringer, H. Ulrich :
A putative RNA helicase of the DEAD box family from Trypanosoma brucei.
In: Molecular and biochemical parasitology, 75 (1) pp. 123-6. ISSN 0166-6851
[Artikel], (1995)

Missel, A. ; Göringer, H. Ulrich :
Trypanosoma brucei mitochondria contain RNA helicase activity.
In: Nucleic acids research, 22 (20) pp. 4050-6. ISSN 0305-1048
[Artikel], (1994)

Murgola, E. J. ; Hijazi, K. A. ; Göringer, H. Ulrich ; Dahlberg, A. E. :
Mutant 16S ribosomal RNA: a codon-specific translational suppressor.
In: Proceedings of the National Academy of Sciences of the United States of America, 85 (12) pp. 4162-5. ISSN 0027-8424
[Artikel], (1988)

Meier, N. ; Göringer, H. Ulrich ; Kleuvers, B. ; Scheibe, U. ; Eberle, J. ; Szymkowiak, C. ; Zacharias, M. ; Wagner, R. :
The importance of individual nucleotides for the structure and function of rRNA molecules in E. coli. A mutagenesis study.
In: FEBS letters, 204 (1) pp. 89-95. ISSN 0014-5793
[Artikel], (1986)

N

Niemann, Moritz ; Kaibel, Heike ; Schlüter, Elke ; Weitzel, Kerstin ; Brecht, Michael ; Göringer, H. Ulrich :
Kinetoplastid RNA editing involves a 3' nucleotidyl phosphatase activity.
In: Nucleic acids research, 37 (6) pp. 1897-906. ISSN 1362-4962
[Artikel], (2009)

Niemann, Moritz ; Brecht, Michael ; Schlüter, Elke ; Weitzel, Kerstin ; Zacharias, Martin ; Göringer, H. Ulrich :
TbMP42 is a structure-sensitive ribonuclease that likely follows a metal ion catalysis mechanism.
In: Nucleic acids research, 36 (13) pp. 4465-73. ISSN 1362-4962
[Artikel], (2008)

O

O'Connor, M. ; Göringer, H. Ulrich ; Dahlberg, A. E. :
A ribosomal ambiguity mutation in the 530 loop of E. coli 16S rRNA.
In: Nucleic acids research, 20 (16) pp. 4221-7. ISSN 0305-1048
[Artikel], (1992)

P

Prescott, C. D. ; Kleuvers, B. ; Göringer, H. Ulrich :
A rRNA-mRNA base pairing model for UGA-dependent termination.
In: Biochimie, 73 (7-8) pp. 1121-9. ISSN 0300-9084
[Artikel], (2011)

Prescott, C. D. ; Göringer, H. Ulrich :
A single mutation in 16S rRNA that affects mRNA binding and translation-termination.
In: Nucleic acids research, 18 (18) pp. 5381-6. ISSN 0305-1048
[Artikel], (1990)

R

Read, L. K. ; Göringer, H. Ulrich ; Stuart, K. :
Assembly of mitochondrial ribonucleoprotein complexes involves specific guide RNA (gRNA)-binding proteins and gRNA domains but does not require preedited mRNA.
In: Molecular and cellular biology, 14 (4) pp. 2629-39. ISSN 0270-7306
[Artikel], (1994)

S

Shu, H. H. ; Göringer, H. Ulrich :
Trypanosoma brucei mitochondrial ribonucleoprotein complexes which contain 12S and 9S ribosomal RNAs.
In: Parasitology, 116 (2) pp. 157-64. ISSN 0031-1820
[Artikel], (1998)

Souza, A. E. ; Göringer, H. Ulrich :
The guide RNA database.
In: Nucleic acids research, 26 (1) pp. 168-9. ISSN 0305-1048
[Artikel], (1998)

Souza, A. E. ; Hermann, T. ; Göringer, H. Ulrich :
The guide RNA database.
In: Nucleic acids research, 25 (1) pp. 104-6. ISSN 0305-1048
[Artikel], (1997)

Schmid, B. ; Read, L. K. ; Stuart, K. ; Göringer, H. Ulrich :
Experimental verification of the secondary structures of guide RNA-pre-mRNA chimaeric molecules in Trypanosoma brucei.
In: European journal of biochemistry / FEBS, 240 (3) pp. 721-31. ISSN 0014-2956
[Artikel], (1996)

Schmid, B. ; Riley, G. R. ; Stuart, K. ; Göringer, H. Ulrich :
The secondary structure of guide RNA molecules from Trypanosoma brucei.
In: Nucleic acids research, 23 (16) pp. 3093-102. ISSN 0305-1048
[Artikel], (1995)

Shu, H. H. ; Stuart, K. ; Göringer, H. Ulrich :
Guide RNA molecules not engaged in RNA editing form ribonucleoprotein complexes free of mRNA.
In: Biochimica et biophysica acta, 1261 (3) pp. 349-59. ISSN 0006-3002
[Artikel], (1995)

V

von Laer, Karl Ludwig :
Selektion und Charakterisierung von RNA-Aptameren zur Genregulation und Antibiotikatherapie.
[Online-Edition: http://tuprints.ulb.tu-darmstadt.de/3296/]
TU Darmstadt , Darmstadt
[Dissertation], (2013)

Z

Zelada-Guillén, Gustavo A. ; Tweed-Kent, Ailis ; Niemann, Moritz ; Göringer, H. Ulrich ; Riu, Jordi ; Rius, F. Xavier :
Ultrasensitive and real-time detection of proteins in blood using a potentiometric carbon-nanotube aptasensor.
In: Biosensors & bioelectronics, 41 pp. 366-71. ISSN 1873-4235
[Artikel], (2013)

Zacharias, M. ; Göringer, H. Ulrich ; Wagner, R. :
Analysis of the Fis-dependent and Fis-independent transcription activation mechanisms of the Escherichia coli ribosomal RNA P1 promoter.
In: Biochemistry, 31 (9) pp. 2621-8. ISSN 0006-2960
[Artikel], (1992)

Zacharias, M. ; Göringer, H. Ulrich ; Wagner, R. :
The signal for growth rate control and stringent sensitivity in E. coli is not restricted to a particular sequence motif within the promoter region.
In: Nucleic acids research, 18 (21) pp. 6271-5. ISSN 0305-1048
[Artikel], (1990)

Zacharias, M. ; Wagner, R. ; Göringer, H. Ulrich :
Polyacrylamide gradient gel electrophoresis for the detection of bended DNA fragments.
In: Nucleic acids research, 18 (9) p. 2827. ISSN 0305-1048
[Artikel], (1990)

Zacharias, M. ; Göringer, H. Ulrich ; Wagner, R. :
Influence of the GCGC discriminator motif introduced into the ribosomal RNA P2- and tac promoter on growth-rate control and stringent sensitivity.
In: The EMBO journal, 8 (11) pp. 3357-63. ISSN 0261-4189
[Artikel], (1989)

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