Göringer, H. Ulrich ; Knieß, Robert ; Leeder, Wolf-Matthias ; Reißig, Paul ; Geyer, Felix Klaus (2022)
Core-shell DNA-cholesterol nanoparticles exert lysosomolytic activity in African trypanosomes.
In: Chembiochem : a European journal of chemical biology, 23 (20)
doi: 10.1002/cbic.202200410
Artikel, Bibliographie
Dies ist die neueste Version dieses Eintrags.
Kurzbeschreibung (Abstract)
Trypanosoma brucei is the causal infectious agent of African trypanosomiasis in humans and Nagana in livestock. Both diseases are currently treated with a small number of chemotherapeutics, which are hampered by a variety of limitations reaching from efficacy and toxicity complications to drug-resistance problems. Here, we explore the forward design of a new class of synthetic trypanocides based on nanostructured, core-shell DNA-lipid particles. In aqueous solution, the particles self-assemble into micelle-type structures consisting of a solvent-exposed, hydrophilic DNA shell and a hydrophobic lipid core. DNA-lipid nanoparticles have membrane-adhesive qualities and can permeabilize lipid membranes. We report the synthesis of DNA-cholesterol nanoparticles, which specifically subvert the membrane integrity of the T. brucei lysosome, killing the parasite with nanomolar potencies.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2022 |
| Autor(en): | Göringer, H. Ulrich ; Knieß, Robert ; Leeder, Wolf-Matthias ; Reißig, Paul ; Geyer, Felix Klaus |
| Art des Eintrags: | Bibliographie |
| Titel: | Core-shell DNA-cholesterol nanoparticles exert lysosomolytic activity in African trypanosomes |
| Sprache: | Englisch |
| Publikationsjahr: | 30 August 2022 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Chembiochem : a European journal of chemical biology |
| Jahrgang/Volume einer Zeitschrift: | 23 |
| (Heft-)Nummer: | 20 |
| DOI: | 10.1002/cbic.202200410 |
| Zugehörige Links: | |
| Kurzbeschreibung (Abstract): | Trypanosoma brucei is the causal infectious agent of African trypanosomiasis in humans and Nagana in livestock. Both diseases are currently treated with a small number of chemotherapeutics, which are hampered by a variety of limitations reaching from efficacy and toxicity complications to drug-resistance problems. Here, we explore the forward design of a new class of synthetic trypanocides based on nanostructured, core-shell DNA-lipid particles. In aqueous solution, the particles self-assemble into micelle-type structures consisting of a solvent-exposed, hydrophilic DNA shell and a hydrophobic lipid core. DNA-lipid nanoparticles have membrane-adhesive qualities and can permeabilize lipid membranes. We report the synthesis of DNA-cholesterol nanoparticles, which specifically subvert the membrane integrity of the T. brucei lysosome, killing the parasite with nanomolar potencies. |
| ID-Nummer: | pmid:36040754 |
| Zusätzliche Informationen: | Artikel-ID: e202200410 |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > Genregulation und RNA-Therapeutika |
| Hinterlegungsdatum: | 06 Sep 2022 08:41 |
| Letzte Änderung: | 28 Nov 2023 13:29 |
| PPN: | 500749604 |
| Zugehörige Links: | |
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| Suche nach Titel in: | TUfind oder in Google |
Verfügbare Versionen dieses Eintrags
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Core‐Shell DNA‐Cholesterol Nanoparticles Exert Lysosomolytic Activity in African Trypanosomes. (deposited 27 Nov 2023 14:10)
- Core-shell DNA-cholesterol nanoparticles exert lysosomolytic activity in African trypanosomes. (deposited 06 Sep 2022 08:41) [Gegenwärtig angezeigt]
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