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'Gestalt,' Composition and Function of the Trypanosoma brucei Editosome.

Göringer, H. Ulrich (2012):
'Gestalt,' Composition and Function of the Trypanosoma brucei Editosome.
In: Annual review of microbiology, pp. 65-82, 66, ISSN 1545-3251,
[Article]

Abstract

RNA editing describes a chemically diverse set of biomolecular reactions in which the nucleotide sequence of RNA molecules is altered. Editing reactions have been identified in many organisms and frequently contribute to the maturation of organellar transcripts. A special editing reaction has evolved within the mitochondria of the kinetoplastid protozoa. The process is characterized by the insertion and deletion of uridine nucleotides into otherwise nontranslatable messenger RNAs. Kinetoplastid RNA editing involves an exclusive class of small, noncoding RNAs known as guide RNAs. Furthermore, a unique molecular machinery, the editosome, catalyzes the process. Editosomes are megadalton multienzyme assemblies that provide a catalytic surface for the individual steps of the reaction cycle. Here I review the current mechanistic understanding and molecular inventory of kinetoplastid RNA editing and the editosome machinery. Special emphasis is placed on the molecular morphology of the editing complex in order to correlate structural features with functional characteristics.

Item Type: Article
Erschienen: 2012
Creators: Göringer, H. Ulrich
Title: 'Gestalt,' Composition and Function of the Trypanosoma brucei Editosome.
Language: English
Abstract:

RNA editing describes a chemically diverse set of biomolecular reactions in which the nucleotide sequence of RNA molecules is altered. Editing reactions have been identified in many organisms and frequently contribute to the maturation of organellar transcripts. A special editing reaction has evolved within the mitochondria of the kinetoplastid protozoa. The process is characterized by the insertion and deletion of uridine nucleotides into otherwise nontranslatable messenger RNAs. Kinetoplastid RNA editing involves an exclusive class of small, noncoding RNAs known as guide RNAs. Furthermore, a unique molecular machinery, the editosome, catalyzes the process. Editosomes are megadalton multienzyme assemblies that provide a catalytic surface for the individual steps of the reaction cycle. Here I review the current mechanistic understanding and molecular inventory of kinetoplastid RNA editing and the editosome machinery. Special emphasis is placed on the molecular morphology of the editing complex in order to correlate structural features with functional characteristics.

Journal or Publication Title: Annual review of microbiology
Volume: 66
Divisions: 10 Department of Biology
10 Department of Biology > Postranscriptional Gene Regulation and RNA Therapeutics
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Date Deposited: 25 Sep 2012 08:15
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