Aphasizheva, Inna ; Alfonzo, Juan ; Carnes, Jason ; Cestari, Igor ; Cruz-Reyes, Jorge ; Göringer, H. Ulrich ; Hajduk, Stephen ; Lukeš, Julius ; Madison-Antenucci, Susan ; Maslov, Dmitri A. ; McDermott, Suzanne M. ; Ochsenreiter, Torsten ; Read, Laurie K. ; Salavati, Reza ; Schnaufer, Achim ; Schneider, André ; Simpson, Larry ; Stuart, Kenneth ; Yurchenko, Vyacheslav ; Zhou, Z. Hong ; Zíková, Alena ; Zhang, Liye ; Zimmer, Sara ; Aphasizhev, Ruslan (2020)
Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes.
In: Trends in parasitology, 36 (4)
doi: 10.1016/j.pt.2020.01.006
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast nucleoid containing mitochondrial DNAs of two kinds: maxicircles encoding ribosomal RNAs (rRNAs) and proteins and minicircles bearing guide RNAs (gRNAs) for mRNA editing. All RNAs are produced by a phage-type RNA polymerase as 3' extended precursors, which undergo exonucleolytic trimming. Most pre-mRNAs proceed through 3' adenylation, uridine insertion/deletion editing, and 3' A/U-tailing. The rRNAs and gRNAs are 3' uridylated. Historically, RNA editing has attracted major research effort, and recently essential pre- and postediting processing events have been discovered. Here, we classify the key players that transform primary transcripts into mature molecules and regulate their function and turnover.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2020 |
| Autor(en): | Aphasizheva, Inna ; Alfonzo, Juan ; Carnes, Jason ; Cestari, Igor ; Cruz-Reyes, Jorge ; Göringer, H. Ulrich ; Hajduk, Stephen ; Lukeš, Julius ; Madison-Antenucci, Susan ; Maslov, Dmitri A. ; McDermott, Suzanne M. ; Ochsenreiter, Torsten ; Read, Laurie K. ; Salavati, Reza ; Schnaufer, Achim ; Schneider, André ; Simpson, Larry ; Stuart, Kenneth ; Yurchenko, Vyacheslav ; Zhou, Z. Hong ; Zíková, Alena ; Zhang, Liye ; Zimmer, Sara ; Aphasizhev, Ruslan |
| Art des Eintrags: | Bibliographie |
| Titel: | Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes. |
| Sprache: | Englisch |
| Publikationsjahr: | April 2020 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Trends in parasitology |
| Jahrgang/Volume einer Zeitschrift: | 36 |
| (Heft-)Nummer: | 4 |
| DOI: | 10.1016/j.pt.2020.01.006 |
| Kurzbeschreibung (Abstract): | Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast nucleoid containing mitochondrial DNAs of two kinds: maxicircles encoding ribosomal RNAs (rRNAs) and proteins and minicircles bearing guide RNAs (gRNAs) for mRNA editing. All RNAs are produced by a phage-type RNA polymerase as 3' extended precursors, which undergo exonucleolytic trimming. Most pre-mRNAs proceed through 3' adenylation, uridine insertion/deletion editing, and 3' A/U-tailing. The rRNAs and gRNAs are 3' uridylated. Historically, RNA editing has attracted major research effort, and recently essential pre- and postediting processing events have been discovered. Here, we classify the key players that transform primary transcripts into mature molecules and regulate their function and turnover. |
| ID-Nummer: | pmid:32191849 |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > Genregulation und RNA-Therapeutika |
| Hinterlegungsdatum: | 25 Mär 2020 07:50 |
| Letzte Änderung: | 25 Mär 2020 07:50 |
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