Artikel

Porro, Alessandro ; Armano, Edoardo ; Brandalise, Federico ; Appiani, Rebecca ; Beltrame, Monica ; Saponaro, Andrea ; Dallanoce, Clelia ; Nakajo, Koichi ; Ryu, Kaei ; Leone, Roberta ; Thiel, Gerhard ; Pallavicini, Marco ; Moroni, Anna ; Bolchi, Cristiano (2024)
A photoactivatable version of ivabradine enables light-induced block of HCN current in vivo.
In: Journal of medicinal chemistry, 67 (18)
doi: 10.1021/acs.jmedchem.4c01047
Artikel, Bibliographie

Saponaro, Andrea ; Krumbach, Jan H. ; Chaves-Sanjuan, Antonio ; Sharifzadeh, Atiyeh Sadat ; Porro, Alessandro ; Castelli, Roberta ; Hamacher, Kay ; Bolognesi, Martino ; DiFrancesco, Dario ; Clarke, Oliver B. ; Thiel, Gerhard ; Moroni, Anna (2024)
Structural determinants of ivabradine block of the open pore of HCN4.
In: Proceedings of the National Academy of Sciences of the United States of America, 121 (27)
doi: 10.1073/pnas.2402259121
Artikel, Bibliographie

Porro, Alessandro ; Saponaro, Andrea ; Castelli, Roberta ; Introini, Bianca ; Hafez Alkotob, Anahita ; Ranjbari, Golnaz ; Enke, Uta ; Kusch, Jana ; Benndorf, Klaus ; Santoro, Bina ; DiFrancesco, Dario ; Thiel, Gerhard ; Moroni, Anna (2024)
A high affinity switch for cAMP in the HCN pacemaker channels.
In: Nature communications, 15 (1)
doi: 10.1038/s41467-024-45136-y
Artikel, Bibliographie

Saponaro, Andrea ; Bauer, Daniel ; Giese, M. Hunter ; Swuec, Paolo ; Porro, Alessandro ; Gasparri, Federica ; Sharifzadeh, Atiyeh Sadat ; Chaves-Sanjuan, Antonio ; Alberio, Laura ; Parisi, Giacomo ; Cerutti, Gabriele ; Clarke, Oliver B. ; Hamacher, Kay ; Colecraft, Henry M. ; Mancia, Filippo ; Hendrickson, Wayne A. ; Siegelbaum, Steven A. ; DiFrancesco, Dario ; Bolognesi, Martino ; Thiel, Gerhard ; Santoro, Bina ; Moroni, Anna (2021)
Gating movements and ion permeation in HCN4 pacemaker channels.
In: Molecular cell, 81 (14)
doi: 10.1016/j.molcel.2021.05.033
Artikel, Bibliographie

Porro, Alessandro ; Thiel, Gerhard ; Moroni, Anna ; Saponaro, Andrea (2020)
Cyclic AMP Regulation and Its Command in the Pacemaker Channel HCN4.
In: Frontiers in physiology, 11
doi: 10.3389/fphys.2020.00771
Artikel, Bibliographie

Laskowski, Michal ; Saponaro, Andrea ; Porro, Alessandro ; Zurbriggen, Matias ; Thiel, Gerhard ; Moroni, Anna (2020)
Lov-Nano as a New Tool for the Regulation of HCN Channels by Blue Light.
In: Biophysical Journal, 118 (3)
doi: 10.1016/j.bpj.2019.11.1558
Artikel, Bibliographie

Porro, Alessandro ; Gasparri, Federica ; Cona, Filippo ; Thiel, Gerhard ; Thei, Federico ; Santoro, Bina ; Saponaro, Andrea ; Moroni, Anna (2020)
The Role of HCN Channel Helices D and E in the Modulation of Camp Affinity.
In: Biophysical Journal, 118 (3)
doi: 10.1016/j.bpj.2019.11.2350
Artikel, Bibliographie

Porro, Alessandro ; Saponaro, Andrea ; Gasparri, Federica ; Bauer, Daniel ; Gross, Christine ; Pisoni, Matteo ; Abbandonato, Gerardo ; Hamacher, Kay ; Santoro, Bina ; Thiel, Gerhard ; Moroni, Anna (2019)
The HCN domain couples voltage gating and cAMP response in Hyperpolarization-activated Cyclic Nucleotide-gated channels.
In: eLife, 8
doi: 10.7554/eLife.49672
Artikel, Bibliographie

Saponaro, Andrea ; Cantini, Francesca ; Porro, Alessandro ; Bucchi, Annalisa ; DiFrancesco, Dario ; Maione, Vincenzo ; Laskowski, Michal ; Mesirca, Pietro ; Mangoni, Matteo ; Thiel, Gerhard ; Banci, Lucia ; Santoro, Bina ; Moroni, Anna (2019)
Developing Synthetic Peptides to Regulate Native HCN Channels.
In: Biophysical Journal, 116 (3)
doi: 10.1016/j.bpj.2018.11.1638
Artikel, Bibliographie

Moroni, Anna ; Porro, Alessandro ; Saponaro, Andrea ; Pisoni, Matteo ; Gasparri, Federica ; Abbandonato, Gerardo ; Thiel, Gerhard ; Santoro, Bina (2019)
The Role of HCN Domain in Channel Gating.
In: Biophysical Journal, 116 (3)
doi: 10.1016/j.bpj.2018.11.2146
Artikel, Bibliographie

Marini, Carla ; Porro, Alessandro ; Rastetter, Agnès ; Dalle, Carine ; Rivolta, Ilaria ; Bauer, Daniel ; Oegema, Renske ; Nava, Caroline ; Parrini, Elena ; Mei, Davide ; Mercer, Catherine ; Dhamija, Radhika ; Chambers, Chelsea ; Coubes, Christine ; Thévenon, Julien ; Kuentz, Paul ; Julia, Sophie ; Pasquier, Laurent ; Dubourg, Christèle ; Carré, Wilfrid ; Rosati, Anna ; Melani, Federico ; Pisano, Tiziana ; Giardino, Maria ; Innes, A. Micheil ; Alembik, Yves ; Scheidecker, Sophie ; Santos, Manuela ; Figueiroa, Sonia ; Garrido, Cristina ; Fusco, Carlo ; Frattini, Daniele ; Spagnoli, Carlotta ; Binda, Anna ; Granata, Tiziana ; Ragona, Francesca ; Freri, Elena ; Franceschetti, Silvana ; Canafoglia, Laura ; Castellotti, Barbara ; Gellera, Cinzia ; Milanesi, Raffaella ; Mancardi, Maria Margherita ; Clark, Damien R. ; Kok, Fernando ; Helbig, Katherine L. ; Ichikawa, Shoji ; Sadler, Laurie ; Neupauerová, Jana ; Laššuthova, Petra ; Šterbová, Katalin ; Laridon, Annick ; Brilstra, Eva ; Koeleman, Bobby ; Lemke, Johannes R. ; Zara, Federico ; Striano, Pasquale ; Soblet, Julie ; Smits, Guillaume ; Deconinck, Nicolas ; Barbuti, Andrea ; DiFrancesco, Dario ; LeGuern, Eric ; Guerrini, Renzo ; Santoro, Bina ; Hamacher, Kay ; Thiel, Gerhard ; Moroni, Anna ; DiFrancesco, Jacopo C. ; Depienne, Christel (2018)
HCN1 mutation spectrum: from neonatal epileptic encephalopathy to benign generalized epilepsy and beyond.
In: Brain : a journal of neurology, 141 (11)
Artikel, Bibliographie

Alberio, Laura ; Locarno, Andrea ; Saponaro, Andrea ; Romano, Edoardo ; Bercier, Valérie ; Albadri, Shahad ; Simeoni, Frederica ; Moleri, Silvia ; Pelucchi, Silvia ; Porro, Alessandro ; Marcello, Elena ; Barsotti, Noemi ; Kukovetz, Kerri ; Boender, Arjen J. ; Contestabile, Andrea ; Luo, Shizhen ; Moutal, Aubin ; Ji, Yingshi ; Romani, Giulia ; Beltrame, Monica ; Del Bene, Filippo ; Di Luca, Monica ; Khanna, Rajesh ; Colecraft, Henry M. ; Pasqualetti, Massimo ; Thiel, Gerhard ; Tonini, Raffaella ; Moroni, Anna (2018)
A light-gated potassium channel for sustained neuronal inhibition.
In: Nature methods, 15 (11)
Artikel, Bibliographie

Saponaro, Andrea ; Cantini, Francesca ; Porro, Alessandro ; Bucchi, Annalisa ; DiFrancesco, Dario ; Maione, Vincenzo ; Donadoni, Chiara ; Introini, Bianca ; Mesirca, Pietro ; Mangoni, Matteo Elia ; Thiel, Gerhard ; Banci, Lucia ; Santoro, Bina ; Moroni, Anna (2018)
A synthetic peptide that prevents cAMP regulation in mammalian Hyperpolarization-activated Cyclic Nucleotide-regulated (HCN) channels.
In: eLife, 7
Artikel, Bibliographie

Saponaro, Andrea ; Porro, Alessandro ; Donadoni, Chiara ; Santoro, Bina ; Thiel, Gerhard ; Moroni, Anna (2018)
Assigning Function to the D and E Helices of HCN CNBD.
In: Biophysical journal, 114 (3)
Artikel, Bibliographie

Saponaro, Andrea ; Porro, Alessandro ; Chaves-Sanjuan, Antonio ; Nardini, Marco ; Rauh, Oliver ; Thiel, Gerhard ; Moroni, Anna (2017)
Fusicoccin Activates KAT1 Channels by Stabilizing their Interaction with 14-3-3- Proteins.
In: The Plant cell, 29 (10)
Artikel, Bibliographie

Saponaro, Andrea ; Porro, Alessandro ; Sanjuan, Antonio C. ; Donadoni, Chiara ; Nardini, Marco ; Thiel, Gerhard ; Moroni, Anna (2017)
Exploring New Pharmacological Perspectives of Fusicoccin, A Stabilizer of 14-3-3-Target Protein Complex.
In: Biophysical journal, 112 (3)
Artikel, Bibliographie