Porro, Alessandro ; Thiel, Gerhard ; Moroni, Anna ; Saponaro, Andrea (2020)
Cyclic AMP Regulation and Its Command in the Pacemaker Channel HCN4.
In: Frontiers in physiology, 11
doi: 10.3389/fphys.2020.00771
Artikel, Bibliographie
Dies ist die neueste Version dieses Eintrags.
Kurzbeschreibung (Abstract)
Direct regulation of the pacemaker "funny" current (I) by cyclic AMP (cAMP) underlies heart rate modulation by the autonomic nervous system. At the molecular level, cAMP activates hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that drive I in sinoatrial node (SAN) myocytes. Even though HCN channel genes were identified more than 20 years ago, the understanding of how cAMP regulates their gating is still fragmented. Here we summarize present understanding on how the cAMP signal is transmitted from the cytosolic to the transmembrane (TM) domain in HCN4. We further discuss how detailed structural knowledge prompted the development of pharmacological/genetic tools for the control of cAMP regulation in these channels.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2020 |
| Autor(en): | Porro, Alessandro ; Thiel, Gerhard ; Moroni, Anna ; Saponaro, Andrea |
| Art des Eintrags: | Bibliographie |
| Titel: | Cyclic AMP Regulation and Its Command in the Pacemaker Channel HCN4. |
| Sprache: | Englisch |
| Publikationsjahr: | 7 Juli 2020 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Frontiers in physiology |
| Jahrgang/Volume einer Zeitschrift: | 11 |
| DOI: | 10.3389/fphys.2020.00771 |
| Zugehörige Links: | |
| Kurzbeschreibung (Abstract): | Direct regulation of the pacemaker "funny" current (I) by cyclic AMP (cAMP) underlies heart rate modulation by the autonomic nervous system. At the molecular level, cAMP activates hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that drive I in sinoatrial node (SAN) myocytes. Even though HCN channel genes were identified more than 20 years ago, the understanding of how cAMP regulates their gating is still fragmented. Here we summarize present understanding on how the cAMP signal is transmitted from the cytosolic to the transmembrane (TM) domain in HCN4. We further discuss how detailed structural knowledge prompted the development of pharmacological/genetic tools for the control of cAMP regulation in these channels. |
| ID-Nummer: | pmid:32733276 |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > Plant Membrane Biophyscis (am 20.12.23 umbenannt in Biologie der Algen und Protozoen) |
| Hinterlegungsdatum: | 05 Aug 2020 06:25 |
| Letzte Änderung: | 06 Dez 2023 09:14 |
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| Suche nach Titel in: | TUfind oder in Google |
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cyclic AMP Regulation and Its Command in the Pacemaker Channel HCN4. (deposited 05 Dez 2023 13:36)
- Cyclic AMP Regulation and Its Command in the Pacemaker Channel HCN4. (deposited 05 Aug 2020 06:25) [Gegenwärtig angezeigt]
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