Saponaro, Andrea ; Krumbach, Jan H. ; Chaves-Sanjuan, Antonio ; Sharifzadeh, Atiyeh Sadat ; Porro, Alessandro ; Castelli, Roberta ; Hamacher, Kay ; Bolognesi, Martino ; DiFrancesco, Dario ; Clarke, Oliver B. ; Thiel, Gerhard ; Moroni, Anna (2024)
Structural determinants of ivabradine block of the open pore of HCN4.
In: Proceedings of the National Academy of Sciences of the United States of America, 121 (27)
doi: 10.1073/pnas.2402259121
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Saponaro, Andrea ; Bauer, Daniel ; Giese, M. Hunter ; Swuec, Paolo ; Porro, Alessandro ; Gasparri, Federica ; Sharifzadeh, Atiyeh Sadat ; Chaves-Sanjuan, Antonio ; Alberio, Laura ; Parisi, Giacomo ; Cerutti, Gabriele ; Clarke, Oliver B. ; Hamacher, Kay ; Colecraft, Henry M. ; Mancia, Filippo ; Hendrickson, Wayne A. ; Siegelbaum, Steven A. ; DiFrancesco, Dario ; Bolognesi, Martino ; Thiel, Gerhard ; Santoro, Bina ; Moroni, Anna (2021)
Gating movements and ion permeation in HCN4 pacemaker channels.
In: Molecular cell, 81 (14)
doi: 10.1016/j.molcel.2021.05.033
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Lolicato, Marco ; Bucchi, Annalisa ; Arrigoni, Cristina ; Zucca, Stefano ; Nardini, Marco ; Schroeder, Indra ; Simmons, Katie ; Aquila, Marco ; DiFrancesco, Dario ; Bolognesi, Martino ; Schwede, Frank ; Kashin, Dmitry ; Fishwick, Colin W. G. ; Johnson, A. Peter ; Thiel, Gerhard ; Moroni, Anna (2014)
Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness.
In: Nature chemical biology, 10 (6)
doi: 10.1038/nchembio.1521
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Lolicato, Marco ; Nardini, Marco ; Gazzarrini, Sabrina ; Möller, Stefan ; Bertinetti, Daniela ; Herberg, Friedrich W. ; Bolognesi, Martino ; Martin, Holger ; Fasolini, Marina ; Bertrand, Jay A. ; Arrigoni, Cristina ; Thiel, Gerhard ; Moroni, Anna (2011)
Tetramerization Dynamics of C-terminal Domain Underlies Isoform-specific cAMP Gating in Hyperpolarization-activated Cyclic Nucleotide-gated Channels.
In: The Journal of biological chemistry, 286 (52)
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