Englisch

Noon, Angela T. ; Shibata, A. ; Rief, N. ; Löbrich, M. ; Stewart, G. S. ; Jeggo, P. A. ; Goodarzi, A. A. (2010)
53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair.
In: Nature Cell Biology, 12 (2)
Artikel, Bibliographie

Kuefner, M. A. ; Grudzenski, S. ; Hamann, J. ; Achenbach, S. ; Lell, Michael ; Anderson, K. ; Schwab, S. A. ; Häberle, L. ; Löbrich, M. ; Uder, M. (2010)
Effect of CT scan protocols on x-ray-induced DNA double-strand breaks in blood lymphocytes of patients undergoing coronary CT angiography.
In: European radiology
Artikel, Bibliographie

Beucher, A. ; Birraux, J. ; Tchouandong, L. ; Barton, O. ; Shibata, A. ; Conrad, S. ; Goodarzi, A. A. ; Krempler, A. ; Jeggo, P. A. ; Löbrich, M. (2009)
ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2.
In: EMBO Journal, 28 (21)
Artikel, Bibliographie

Grudzenski, S. ; Küfner, M. A. ; Heckmann, M. B. ; Uder, M. ; Löbrich, M. (2009)
Contrast Medium-enhanced Radiation Damage Caused by CT Examinations.
In: Radiology
Artikel, Bibliographie

Küfner, M. A. ; Grudzenski, S. ; Schwab, S. A. ; Wiederseiner, M. ; Heckmann, M. ; Bautz, W. ; Löbrich, M. ; Uder, M. (2009)
DNA double-strand breaks and their repair in blood lymphocytes of patients undergoing angiographic procedures.
In: Investigative Radiology, 44 (8)
Artikel, Bibliographie

Küfner, M. A. ; Grudzenski, S. ; Schwab, S. A. ; Azoulay, S. ; Heckmann, M. ; Heinrich, M. C. ; Löbrich, M. ; Uder, M. (2009)
X-ray-induced DNA double-strand breaks after angiographic examinations of different anatomic regions.
In: Rofo, 181 (4)
Artikel, Bibliographie

Rübe, C. E. ; Grudzenski, S. ; Kühne, M. ; Dong, X. ; Rief, N. ; Löbrich, M. ; Rübe, C. (2008)
DNA double-strand break repair of blood lymphocytes and normal tissues analysed in a preclinical mouse model: implications for radiosensitivity testing.
In: Clinical Cancer Research, 14 (20)
Artikel, Bibliographie

Goodarzi, A. A. ; Noon, A. ; Deckbar, D. ; Ziv, Y. ; Shiloh, Y. ; Löbrich, M. ; Jeggo, P. A. (2008)
ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin.
In: Molecular Cell, 31 (2)
Artikel, Bibliographie

Toulany, M. ; Kehlbach, R. ; Florczak, U. ; Sak, A. ; Wang, S. ; Chen, J. ; Löbrich, M. ; Rodemann, H. P. (2008)
Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair.
In: Molecular Cancer Therapeutics, 7 (7)
Artikel, Bibliographie

Rothkamm, K. ; Gunasekara, K. ; Warda, S. ; Krempler, A. ; Löbrich, M. (2008)
Radiation-induced HPRT mutations resulting from misrejoined DNA double-strand breaks.
In: Radiation Research, 169 (6)
Artikel, Bibliographie

Seifert, M. ; Scherer, S. J. ; Edelmann, W. ; Böhm, M. ; Meineke, V. ; Löbrich, M. ; Tilgen, W. ; Reichrath, J. (2008)
The DNA-mismatch repair enzyme hMSH2 modulates UV-B-induced cell cycle arrest and apoptosis in melanoma cells.
In: Journal of Investigative Dermatology, 128 (1)
Artikel, Bibliographie

Jeggo, P. A. ; Löbrich, M. (2007)
DNA double-strand breaks: their cellular and clinical impact?
In: Oncogene, 26 (56)
Artikel, Bibliographie

Kegel, P. ; Riballo, E. ; Kühne, M. ; Jeggo, P. A. ; Löbrich, M. (2007)
X-irradiation of cells on glass slides has a dose doubling impact.
In: DNA Repair, 6 (11)
Artikel, Bibliographie

Löbrich, M. ; Jeggo, P. A. (2007)
The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.
In: Nature Reviews Cancer, 7 (11)
Artikel, Bibliographie

Krempler, A. ; Deckbar, D. ; Jeggo, P. A. ; Löbrich, M. (2007)
An imperfect G2M checkpoint contributes to chromosome instability following irradiation of S and G2 phase cells.
In: Cell Cycle, 6 (14)
Artikel, Bibliographie

Hunt, C. R. ; Pandita, R. K. ; Laszlo, A. ; Higashikubo, R. ; Agarwal, M. ; Kitamura, T. ; Gupta, A. ; Rief, N. ; Horikoshi, N. ; Baskaran, R. ; Lee, J. H. ; Löbrich, M. ; Paull, T. T. ; Roti Roti, J. L. ; Pandita, T. K. (2007)
Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status.
In: Cancer Research, 67 (7)
Artikel, Bibliographie

Deckbar, D. ; Birraux, J. ; Krempler, A. ; Tchouandong, L. ; Beucher, A. ; Walker, S. ; Stiff, T. ; Jeggo, P. A. ; Löbrich, M. (2007)
Chromosome breakage after G2 checkpoint release.
In: Journal of Cell Biology, 176 (6)
Artikel, Bibliographie

Chen, B. P. ; Uematsu, N. ; Kobayashi, J. ; Lerenthal, Y. ; Krempler, A. ; Yajima, H. ; Löbrich, M. ; Shiloh, Y. ; Chen, D. J. (2007)
Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.
In: Journal of Biological Chemistry, 282 (9)
Artikel, Bibliographie

Jeggo, P. A. ; Löbrich, M. (2006)
Contribution of DNA repair and cell cycle checkpoint arrest to the maintenance of genomic stability.
In: DNA Repair, 5 (9-10)
Artikel, Bibliographie

Löbrich, M. ; Kiefer, J. (2006)
Assessing the likelihood of severe side effects in radiotherapy.
In: International Journal of Cancer, 118 (11)
Artikel, Bibliographie

Jeggo, P. A. ; Löbrich, M. (2006)
Radiation-induced DNA damage responses.
In: Radiation Protection Dosimetry, 122 (1-4)
Artikel, Bibliographie

Kühne, M. ; Urban, G. ; Frankenberg, D. ; Löbrich, M. (2005)
DNA double-strand break misrejoining after exposure of primary human fibroblasts to CK characteristic X rays, 29 kVp X rays and 60Co gamma rays.
In: Radiation Research, 164 (5)
Artikel, Bibliographie

Löbrich, M. ; Jeggo, P. A. (2005)
The two edges of the ATM sword: co-operation between repair and checkpoint functions.
In: Radiotherapy and Oncology, 76 (2)
Artikel, Bibliographie

Löbrich, M. ; Jeggo, P. A. (2005)
Harmonising the response to DSBs: a new string in the ATM bow.
In: DNA Repair, 4 (7)
Artikel, Bibliographie

Löbrich, M. ; Rief, N. ; Kühne, M. ; Heckmann, M. ; Fleckenstein, J. ; Rübe, C. ; Uder, M. (2005)
In vivo formation and repair of DNA double-strand breaks after computed tomography examinations.
In: Proceedings of the National Academy of Sciences USA, 102 (25)
Artikel, Bibliographie

Jeggo, P. A. ; Löbrich, M. (2005)
Artemis links ATM to double strand break rejoining.
In: Cell Cycle, 4 (3)
Artikel, Bibliographie

Riballo, E. ; Kühne, M. ; Rief, N. ; Doherty, A. ; Smith, G. C. M. ; Recio, M. J. ; Reis, C. ; Dahm, K. ; Fricke, A. ; Krempler, A. ; Parker, A. R. ; Jackson, S. P. ; Gennery, A. ; Jeggo, P. A. ; Löbrich, M. (2004)
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.
In: Molecular Cell, 16 (5)
Artikel, Bibliographie

Stiff, T. ; O'Driscoll, M. ; Rief, N. ; Iwabuchi, K. ; Löbrich, M. ; Jeggo, P. A. (2004)
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation.
In: Cancer Research, 64 (7)
Artikel, Bibliographie

Kühne, M. ; Riballo, E. ; Rief, N. ; Rothkamm, K. ; Jeggo, P. A. ; Löbrich, M. (2004)
A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity.
In: Cancer Research, 64 (2)
Artikel, Bibliographie

Krüger, I. ; Rothkamm, K. ; Löbrich, M. (2004)
Enhanced fidelity for rejoining radiation-induced DNA double-strand breaks in the G2 phase of Chinese hamster ovary cells.
In: Nucleic Acids Research, 32 (9)
Artikel, Bibliographie

Rothkamm, K. ; Krüger, I. ; Thompson, L. H. ; Löbrich, M. (2003)
Pathways of DNA double-strand break repair during the mammalian cell cycle.
In: Molecular Cell Biology, 23 (16)
Artikel, Bibliographie

Rothkamm, K. ; Löbrich, M. (2003)
Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses.
In: Proceedings of the National Academy of Sciences USA, 100 (9)
Artikel, Bibliographie

Rothkamm, K. ; Löbrich, M. (2002)
Misrepair of radiation-induced DNA double-strand breaks and its relevance for tumorigenesis and cancer treatment (review).
In: International Journal of Oncology, 21 (2)
Artikel, Bibliographie

Rydberg, B. ; Heilbronn, L. ; Holley, W. R. ; Löbrich, M. ; Zeitlin, C. ; Chatterjee, A. ; Cooper, P. K. (2002)
Spatial distribution and yield of DNA double-strand breaks induced by 3-7 MeV helium ions in human fibroblasts.
In: Radiation Research, 158 (1)
Artikel, Bibliographie

Rief, N. ; Löbrich, M. (2002)
Efficient rejoining of radiation-induced DNA double-strand breaks in centromeric DNA of human cells.
In: Journal of Biological Chemistry, 277 (23)
Artikel, Bibliographie

Tabocchini, M. A. ; Belli, M. ; Campa, A. ; Löbrich, M. ; Sapora, O. ; Simone, G. ; Stenerlow, B. (2002)
Induction and repair of DNA damage in human cells at different stages of differentiation.
In: Radiation Protection Dosimetry, 99 (1-4)
Artikel, Bibliographie

Kühne, M. ; Rothkamm, K. ; Löbrich, M. (2002)
Physical and biological parameters affecting DNA double strand break misrejoining in mammalian cells.
In: Radiation Protection Dosimetry, 99 (1-4)
Artikel, Bibliographie

Rothkamm, K. ; Kühne, M. ; Jeggo, P. A. ; Löbrich, M. (2001)
Radiation-induced genomic rearrangements formed by nonhomologous end-joining of DNA double-strand breaks.
In: Cancer Research, 61 (10)
Artikel, Bibliographie

Tabocchini, M. A. ; Rothkamm, K. ; Signoretti, C. ; Risse, J. ; Sapora, O. ; Löbrich, M. (2000)
Formation and repair of DNA double-strand breaks in gamma-irradiated K562 cells undergoing erythroid differentiation.
In: Mutation Research, 461 (1)
Artikel, Bibliographie

Kühne, M. ; Rothkamm, K. ; Löbrich, M. (2000)
No dose-dependence of DNA double-strand break misrejoining following alpha-particle irradiation.
In: International Journal of Radiation Biology, 76 (7)
Artikel, Bibliographie

Löbrich, M. ; Kühne, M. ; Wetzel, J. ; Rothkamm, K. (2000)
Joining of correct and incorrect DNA double-strand break ends in normal human and ataxia telangiectasia fibroblasts.
In: Genes Chromosomes Cancer, 27 (1)
Artikel, Bibliographie

Rothkamm, K. ; Löbrich, M. (1999)
Misrejoining of DNA double-strand breaks in primary and transformed human and rodent cells: a comparison between the HPRT region and other genomic locations.
In: Mutation Research, 433 (3)
Artikel, Bibliographie

Löbrich, M. ; Cooper, P. K. ; Rydberg, B. (1998)
Joining of correct and incorrect DNA ends at double-strand breaks produced by high-linear energy transfer radiation in human fibroblasts.
In: Radiation Research, 150 (6)
Artikel, Bibliographie

Prise, K. M. ; Ahnstrom, G. ; Belli, M. ; Carlsson, J. ; Frankenberg, D. ; Kiefer, J. ; Löbrich, M. ; Michael, B. D. ; Nygren, J. ; Simone, G. ; Stenerlow, B. (1998)
A review of dsb induction data for varying quality radiations.
In: International Journal of Radiation Biology, 74 (2)
Artikel, Bibliographie

Rydberg, B. ; Löbrich, M. ; Cooper, P. K. (1998)
Repair of clustered DNA damage caused by high LET radiation in human fibroblasts.
In: Physica medica, Supplement, 14 (1)
Artikel, Bibliographie

Löbrich, M. (1998)
Induction and repair of DNA double-strand breaks in human fibroblasts after particle irradiation.
In: Advances in Space Research, 22 (4)
Artikel, Bibliographie

Löbrich, M. ; Cooper, P. K. ; Rydberg, B. (1996)
Non-random distribution of DNA double-strand breaks induced by particle irradiation.
In: International Journal of Radiation Biology, 70 (5)
Artikel, Bibliographie

Löbrich, M. ; Rydberg, B. ; Cooper, P. K. (1996)
Random-breakage mapping method applied to human DNA sequences.
In: Nucleic Acids Research, 24 (10)
Artikel, Bibliographie

Löbrich, M. ; Rydberg, B. ; Cooper, P. K. (1995)
Repair of x-ray-induced DNA double-strand breaks in specific Not I restriction fragments in human fibroblasts: joining of correct and incorrect ends.
In: Proceedings of the National Academy of Sciences USA, 92 (26)
Artikel, Bibliographie

Ikpeme, S. ; Löbrich, M. ; Akpa, T. ; Schneider, E. ; Kiefer, J. (1995)
Heavy ion-induced DNA double-strand breaks with yeast as a model system.
In: Radiation and Environmental Biophysics, 34 (2)
Artikel, Bibliographie

Rydberg, B. ; Löbrich, M. ; Cooper, P. K. (1994)
DNA double-strand breaks induced by high-energy neon and iron ions in human fibroblasts. I. Pulsed-field gel electrophoresis method.
In: Radiation Research, 139 (2)
Artikel, Bibliographie

Löbrich, M. ; Rydberg, B. ; Cooper, P. K. (1994)
DNA double-strand breaks induced by high-energy neon and iron ions in human fibroblasts. II. Probing individual notI fragments by hybridization.
In: Radiation Research, 139 (2)
Artikel, Bibliographie

Löbrich, M. ; Ikpeme, S. ; Kiefer, J. (1994)
DNA double-strand break measurement in mammalian cells by pulsed-field gel electrophoresis: an approach using restriction enzymes and gene probing.
In: International Journal of Radiation Biology, 65 (6)
Artikel, Bibliographie

Löbrich, M. ; Ikpeme, S. ; Kiefer, J. (1994)
Measurement of DNA double-strand breaks in mammalian cells by pulsed-field gel electrophoresis: a new approach using rarely cutting restriction enzymes.
In: Radiation Research, 138 (2)
Artikel, Bibliographie

Löbrich, M. ; Ikpeme, S. ; Haub, P. ; Weber, K. J. ; Kiefer, J. (1993)
DNA double-strand break induction in yeast by X-rays and alpha-particles measured by pulsed-field gel electrophoresis.
In: International Journal of Radiation Biology, 64 (5)
Artikel, Bibliographie

Löbrich, M. ; Ikpeme, S. ; Kiefer, J. (1993)
Analysis of the inversion effect in pulsed field gel electrophoresis by a two-dimensional contour-clamped homogeneous electric field system.
In: Analytical Biochemistry, 208 (1)
Artikel, Bibliographie