Arras, Paul ; Zimmermann, Jasmin ; Lipinski, Britta ; Valldorf, Bernhard ; Evers, Andreas ; Elter, Desislava ; Krah, Simon ; Doerner, Achim ; Guarnera, Enrico ; Siegmund, Vanessa ; Kolmar, Harald ; Pekar, Lukas ; Zielonka, Stefan (2024)
Bovine ultralong CDR-H3 derived knob paratopes elicit potent TNF-α neutralization and enable the generation of novel adalimumab-based antibody architectures with augmented features.
In: Biological Chemistry
doi: 10.1515/hsz-2023-0370
Artikel, Bibliographie

Lipinski, Britta ; Arras, Paul ; Pekar, Lukas ; Klewinghaus, Daniel ; Boje, Ammelie Svea ; Krah, Simon ; Zimmermann, Jasmin ; Klausz, Katja ; Peipp, Matthias ; Siegmund, Vanessa ; Evers, Andreas ; Zielonka, Stefan (2023)
NKp46‐specific single domain antibodies enable facile engineering of various potent NK cell engager formats.
In: Protein Science, 32 (3)
doi: 10.1002/pro.4593
Artikel, Bibliographie

Klewinghaus, Daniel ; Pekar, Lukas ; Arras, Paul ; Krah, Simon ; Valldorf, Bernhard ; Kolmar, Harald ; Zielonka, Stefan (2022)
Grabbing the Bull by Both Horns: Bovine Ultralong CDR-H3 Paratopes Enable Engineering of ‘Almost Natural’ Common Light Chain Bispecific Antibodies Suitable For Effector Cell Redirection.
In: Frontiers in Immunology, 12
doi: 10.3389/fimmu.2021.801368
Artikel, Bibliographie

Fibing, David ; Bogen, Jan P. ; Carrara, Stefania C. ; Deweid, Lukas ; Zielonka, Stefan ; Grzeschik, Julius ; Hock, Björn ; Kolmar, Harald (2022)
Streamlining the Transition From Yeast Surface Display of Antibody Fragment Immune Libraries to the Production as IgG Format in Mammalian Cells.
In: Frontiers in Bioengineering and Biotechnology, 10
doi: 10.3389/fbioe.2022.794389
Artikel, Bibliographie

Pekar, Lukas ; Klewinghaus, Daniel ; Arras, Paul ; Carrara, Stefania C. ; Harwardt, Julia ; Krah, Simon ; Yanakieva, Desislava ; Toleikis, Lars ; Smider, Vaughn V. ; Kolmar, Harald ; Zielonka, Stefan (2021)
Milking the cow: cattle-derived chimeric ultralong CDR-H3 antibodies and their engineered CDR-H3-only knobbody counterparts targeting epidermal growth factor receptor elicit potent NK cell-mediated cytotoxicity.
In: Frontiers in Immunology, 12
doi: 10.3389/fimmu.2021.742418
Artikel, Bibliographie

Macarrón Palacios, Arturo ; Grzeschik, Julius ; Deweid, Lukas ; Krah, Simon ; Zielonka, Stefan ; Rösner, Thies ; Peipp, Matthias ; Valerius, Thomas ; Kolmar, Harald (2020)
Specific targeting of lymphoma cells using semisynthetic anti-idiotype shark antibodies.
In: Frontiers in Immunology, 11
doi: 10.3389/fimmu.2020.560244
Artikel, Bibliographie

Hinz, Steffen C. ; Elter, Adrian ; Rammo, Oliver ; Schwämmle, Achim ; Ali, Ataurehman ; Zielonka, Stefan ; Herget, Thomas ; Kolmar, Harald (2020)
A Generic Procedure for the Isolation of pH- and Magnesium-Responsive Chicken scFvs for Downstream Purification of Human Antibodies.
In: Frontiers in Bioengineering and Biotechnology, 8
doi: 10.3389/fbioe.2020.00688
Artikel, Bibliographie

Bogen, Jan P. ; Hinz, Steffen C. ; Grzeschik, Julius ; Ebenig, Aileen ; Krah, Simon ; Zielonka, Stefan ; Kolmar, Harald (2019)
Dual function pH responsive bispecific antibodies for tumor targeting and antigen depletion in plasma.
In: Frontiers in Immunology, 10
doi: 10.3389/fimmu.2019.01892
Artikel, Bibliographie

Krah, Simon ; Kolmar, Harald ; Becker, Stefan ; Zielonka, Stefan (2018)
Engineering IgG-like bispecific antibodies — an overview.
In: Antibodies, 7 (3)
doi: 10.3390/antib7030028
Artikel, Bibliographie

Schröter, Christian ; Becker, Jan ; Krah, Simon ; Zielonka, Stefan ; Doerner, Achim ; Rhiel, Laura ; Günther, Ralf ; Toleikis, Lars ; Kolmar, Harald ; Hock, Björn ; Becker, Stefan (2018)
Selection of antibodies with tailored properties by application of high-throughput multiparameter fluorescence-activated cell sorting of yeast-displayed immune libraries.
In: Molecular Biotechnology, 60
doi: 10.1007/s12033-018-0109-0
Artikel, Bibliographie

Könning, Doreen ; Rhiel, Laura ; Empting, Martin ; Grzeschik, Julius ; Sellmann, Carolin ; Schröter, Christian ; Zielonka, Stefan ; Dickgießer, Stephan ; Pirzer, Thomas ; Yanakieva, Desislava ; Becker, Stefan ; Kolmar, Harald (2017)
Semi-synthetic vNAR libraries screened against therapeutic antibodies primarily deliver anti-idiotypic binders.
In: Scientific Reports, 7 (1)
doi: 10.1038/s41598-017-10513-9
Artikel, Bibliographie

Zielonka, Stefan (2015)
The shark strikes twice: Generation of Mono- and Bispecific High-Affinity vNAR Antibody Domains via Step-Wise Affinity Maturation.
Technische Universität Darmstadt
Dissertation, Erstveröffentlichung

Uth, Christina ; Zielonka, Stefan ; Hoerner, Sebastian ; Rasche, Nicolas ; Plog, Andreas ; Orelma, Hannes ; Avrutina, Olga ; Zhang, Kai ; Kolmar, Harald (2014)
A Chemoenzymatic Approach to Protein Immobilization onto Crystalline Cellulose Nanoscaffolds.
In: Angewandte Chemie-International Edition, 53
Artikel, Bibliographie