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Current Perspectives on Biotechnological Cannabinoid Production in Plants.

Schachtsiek, Julia and Warzecha, Heribert and Kayser, Oliver and Stehle, Felix (2018):
Current Perspectives on Biotechnological Cannabinoid Production in Plants.
84, In: Planta medica, (4), pp. 214-220. ISSN 1439-0221,
[Article]

Abstract

The plant Cannabis sativa contains a number of psychoactive chemical compounds, the cannabinoids, which possess a significant pharmaceutical potential. Recently, the usage of Cannabis for medicinal purposes was legalized in many countries. Thus, the study on the influence of different cannabinoids in combination with other Cannabis-derived compounds with respect to the treatment of various diseases becomes increasingly important. Besides the production of distinct cannabinoids in a heterologous host, like tobacco or yeast, transgenic Cannabis plants would be a suitable alternative to modify and therefore optimize the cannabinoid profile. This perspective highlights the current efforts on Cannabis cell culture systems, in vitro propagation, and transformation of the plant and reveals the resulting opportunities concerning biotechnological production of cannabinoids. Furthermore, alternative platform organisms for the heterologous production of cannabinoids, like tobacco, are considered and evaluated.

Item Type: Article
Erschienen: 2018
Creators: Schachtsiek, Julia and Warzecha, Heribert and Kayser, Oliver and Stehle, Felix
Title: Current Perspectives on Biotechnological Cannabinoid Production in Plants.
Language: English
Abstract:

The plant Cannabis sativa contains a number of psychoactive chemical compounds, the cannabinoids, which possess a significant pharmaceutical potential. Recently, the usage of Cannabis for medicinal purposes was legalized in many countries. Thus, the study on the influence of different cannabinoids in combination with other Cannabis-derived compounds with respect to the treatment of various diseases becomes increasingly important. Besides the production of distinct cannabinoids in a heterologous host, like tobacco or yeast, transgenic Cannabis plants would be a suitable alternative to modify and therefore optimize the cannabinoid profile. This perspective highlights the current efforts on Cannabis cell culture systems, in vitro propagation, and transformation of the plant and reveals the resulting opportunities concerning biotechnological production of cannabinoids. Furthermore, alternative platform organisms for the heterologous production of cannabinoids, like tobacco, are considered and evaluated.

Journal or Publication Title: Planta medica
Volume: 84
Number: 4
Divisions: 10 Department of Biology
10 Department of Biology > Plant Biotechnology and Metabolic Engineering
Date Deposited: 09 Jan 2018 09:29
Identification Number: pmid:29301148
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