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The case for plant-made veterinary immunotherapeutics.

Topp, Edward and Irwin, Rebecca and McAllister, Tim and Lessard, Martin and Joensuu, Jussi J. and Kolotilin, Igor and Conrad, Udo and Stöger, Eva and Mor, Tsafrir and Warzecha, Heribert and Hall, J Chris and McLean, Michael D. and Cox, Eric and Devriendt, Bert and Potter, Andrew and Depicker, Ann and Virdi, Vikram and Holbrook, Larry and Doshi, Ketan and Dussault, Marike and Friendship, Robert and Yarosh, Oksana and Yoo, Han Sang and MacDonald, Jacqueline and Menassa, Rima (2016):
The case for plant-made veterinary immunotherapeutics.
In: Biotechnology advances, pp. 597-604, 34, (5), ISSN 1873-1899,
[Article]

Abstract

The excessive use of antibiotics in food animal production has contributed to resistance in pathogenic bacteria, thereby triggering regulations and consumer demands to limit their use. Alternatives for disease control are therefore required that are cost-effective and compatible with intensive production. While vaccines are widely used and effective, they are available against a minority of animal diseases, and development of novel vaccines and other immunotherapeutics is therefore needed. Production of such proteins recombinantly in plants can provide products that are effective and safe, can be orally administered with minimal processing, and are easily scalable with a relatively low capital investment. The present report thus advocates the use of plants for producing vaccines and antibodies to protect farm animals from diseases that have thus far been managed with antibiotics; and highlights recent advances in product efficacy, competitiveness, and regulatory approval.

Item Type: Article
Erschienen: 2016
Creators: Topp, Edward and Irwin, Rebecca and McAllister, Tim and Lessard, Martin and Joensuu, Jussi J. and Kolotilin, Igor and Conrad, Udo and Stöger, Eva and Mor, Tsafrir and Warzecha, Heribert and Hall, J Chris and McLean, Michael D. and Cox, Eric and Devriendt, Bert and Potter, Andrew and Depicker, Ann and Virdi, Vikram and Holbrook, Larry and Doshi, Ketan and Dussault, Marike and Friendship, Robert and Yarosh, Oksana and Yoo, Han Sang and MacDonald, Jacqueline and Menassa, Rima
Title: The case for plant-made veterinary immunotherapeutics.
Language: English
Abstract:

The excessive use of antibiotics in food animal production has contributed to resistance in pathogenic bacteria, thereby triggering regulations and consumer demands to limit their use. Alternatives for disease control are therefore required that are cost-effective and compatible with intensive production. While vaccines are widely used and effective, they are available against a minority of animal diseases, and development of novel vaccines and other immunotherapeutics is therefore needed. Production of such proteins recombinantly in plants can provide products that are effective and safe, can be orally administered with minimal processing, and are easily scalable with a relatively low capital investment. The present report thus advocates the use of plants for producing vaccines and antibodies to protect farm animals from diseases that have thus far been managed with antibiotics; and highlights recent advances in product efficacy, competitiveness, and regulatory approval.

Journal or Publication Title: Biotechnology advances
Volume: 34
Number: 5
Divisions: 10 Department of Biology
10 Department of Biology > Plant Biotechnology and Metabolic Engineering
Date Deposited: 23 Feb 2016 10:43
Identification Number: doi:10.1016/j.biotechadv.2016.02.007
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