Xia, Liqun ; Lin, Haili ; Staniek, Agata ; Panjikar, Santosh ; Ruppert, Martin ; Hilgers, Petra ; Williardt, Jörg ; Rajendran, Chitra ; Wang, Meitian ; Warzecha, Heribert ; Jäger, Volker ; Stöckigt, Joachim (2015)
Ligand structures of synthetic deoxa-pyranosylamines with raucaffricine and strictosidine glucosidases provide structural insights into their binding and inhibitory behaviours.
In: Journal of enzyme inhibition and medicinal chemistry, 30 (3)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Abstract Insight into the structure and inhibition mechanism of O-β-d-glucosidases by deoxa-pyranosylamine type inhibitors is provided by X-ray analysis of complexes between raucaffricine and strictosidine glucosidases and N-(cyclohexylmethyl)-, N-(cyclohexyl)- and N-(bromobenzyl)-β-d-gluco-1,5-deoxa-pyranosylamine. All inhibitors anchored exclusively in the catalytic active site by competition with appropriate enzyme substrates. Thus facilitated prospective elucidation of the binding networks with residues located at <3.9 Å distance will enable the development of potent inhibitors suitable for the production of valuable alkaloid glucosides, raucaffricine and strictosidine, by means of synthesis in Rauvolfia serpentina cell suspension cultures.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2015 |
| Autor(en): | Xia, Liqun ; Lin, Haili ; Staniek, Agata ; Panjikar, Santosh ; Ruppert, Martin ; Hilgers, Petra ; Williardt, Jörg ; Rajendran, Chitra ; Wang, Meitian ; Warzecha, Heribert ; Jäger, Volker ; Stöckigt, Joachim |
| Art des Eintrags: | Bibliographie |
| Titel: | Ligand structures of synthetic deoxa-pyranosylamines with raucaffricine and strictosidine glucosidases provide structural insights into their binding and inhibitory behaviours. |
| Sprache: | Englisch |
| Publikationsjahr: | 2015 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Journal of enzyme inhibition and medicinal chemistry |
| Jahrgang/Volume einer Zeitschrift: | 30 |
| (Heft-)Nummer: | 3 |
| Kurzbeschreibung (Abstract): | Abstract Insight into the structure and inhibition mechanism of O-β-d-glucosidases by deoxa-pyranosylamine type inhibitors is provided by X-ray analysis of complexes between raucaffricine and strictosidine glucosidases and N-(cyclohexylmethyl)-, N-(cyclohexyl)- and N-(bromobenzyl)-β-d-gluco-1,5-deoxa-pyranosylamine. All inhibitors anchored exclusively in the catalytic active site by competition with appropriate enzyme substrates. Thus facilitated prospective elucidation of the binding networks with residues located at <3.9 Å distance will enable the development of potent inhibitors suitable for the production of valuable alkaloid glucosides, raucaffricine and strictosidine, by means of synthesis in Rauvolfia serpentina cell suspension cultures. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > Plant Biotechnology and Metabolic Engineering |
| Hinterlegungsdatum: | 07 Jul 2015 08:20 |
| Letzte Änderung: | 16 Sep 2015 11:36 |
| PPN: | |
| Export: | |
| Suche nach Titel in: | TUfind oder in Google |
 |
Frage zum Eintrag |
Optionen (nur für Redakteure)
 |
Redaktionelle Details anzeigen |
Drucken
Impressum