Glenz, K. ; Bouchon, B. ; Stehle, T. ; Wallich, R. ; Simon, M. M. ; Warzecha, Heribert (2006)
Production of a recombinant bacterial lipoprotein in higher plant chloroplasts.
In: Nature biotechnology, 24 (1)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Little is known about the potential of plastids to accomplish post-translational modifications of foreign proteins. In the present study we generated transplastomic tobacco plants that accumulate the outer surface lipoprotein A (OspA)-the basic constituent of the first generation monovalent human vaccine against Lyme disease. The recombinant OspA exhibits a lipid modification typical for bacteria and induced protective antibodies in mice, demonstrating that functionally active bacterial lipoproteins can be processed in plants.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2006 |
| Autor(en): | Glenz, K. ; Bouchon, B. ; Stehle, T. ; Wallich, R. ; Simon, M. M. ; Warzecha, Heribert |
| Art des Eintrags: | Bibliographie |
| Titel: | Production of a recombinant bacterial lipoprotein in higher plant chloroplasts. |
| Sprache: | Englisch |
| Publikationsjahr: | 2006 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Nature biotechnology |
| Jahrgang/Volume einer Zeitschrift: | 24 |
| (Heft-)Nummer: | 1 |
| Kurzbeschreibung (Abstract): | Little is known about the potential of plastids to accomplish post-translational modifications of foreign proteins. In the present study we generated transplastomic tobacco plants that accumulate the outer surface lipoprotein A (OspA)-the basic constituent of the first generation monovalent human vaccine against Lyme disease. The recombinant OspA exhibits a lipid modification typical for bacteria and induced protective antibodies in mice, demonstrating that functionally active bacterial lipoproteins can be processed in plants. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie > Plant Biotechnology and Metabolic Engineering ?? fb10_botanik ?? 10 Fachbereich Biologie |
| Hinterlegungsdatum: | 17 Mär 2011 11:01 |
| Letzte Änderung: | 05 Mär 2013 09:46 |
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