Friedel, Laura ; Loewer, Alexander (2023)
The guardian's choice: how p53 enables context‐specific decision‐making in individual cells.
In: The FEBS Journal, 2021
doi: 10.26083/tuprints-00020129
Artikel, Zweitveröffentlichung, Verlagsversion
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Kurzbeschreibung (Abstract)
p53 plays a central role in defending the genomic integrity of our cells. In response to genotoxic stress, this tumour suppressor orchestrates the expression of hundreds of target genes, which induce a variety of cellular outcomes ranging from damage repair to induction of apoptosis. In this review, we examine how the p53 response is regulated on several levels in individual cells to allow precise and context‐specific fate decisions. We discuss that the p53 response is not only controlled by its canonical regulators but also controlled by interconnected signalling pathways that influence the dynamics of p53 accumulation upon damage and modulate its transcriptional activity at target gene promoters. Additionally, we consider how the p53 response is diversified through a variety of mechanisms at the promoter level and beyond to induce context‐specific outcomes in individual cells. These layers of regulation allow p53 to react in a stimulus‐specific manner and fine‐tune its signalling according to the individual needs of a given cell, enabling it to take the right decision on survival or death.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2023 |
| Autor(en): | Friedel, Laura ; Loewer, Alexander |
| Art des Eintrags: | Zweitveröffentlichung |
| Titel: | The guardian's choice: how p53 enables context‐specific decision‐making in individual cells |
| Sprache: | Englisch |
| Publikationsjahr: | 22 Dezember 2023 |
| Ort: | Darmstadt |
| Publikationsdatum der Erstveröffentlichung: | 2021 |
| Ort der Erstveröffentlichung: | Oxford |
| Verlag: | Wiley-Blackwell |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | The FEBS Journal |
| DOI: | 10.26083/tuprints-00020129 |
| URL / URN: | https://tuprints.ulb.tu-darmstadt.de/20129 |
| Zugehörige Links: | |
| Herkunft: | Zweitveröffentlichung DeepGreen |
| Kurzbeschreibung (Abstract): | p53 plays a central role in defending the genomic integrity of our cells. In response to genotoxic stress, this tumour suppressor orchestrates the expression of hundreds of target genes, which induce a variety of cellular outcomes ranging from damage repair to induction of apoptosis. In this review, we examine how the p53 response is regulated on several levels in individual cells to allow precise and context‐specific fate decisions. We discuss that the p53 response is not only controlled by its canonical regulators but also controlled by interconnected signalling pathways that influence the dynamics of p53 accumulation upon damage and modulate its transcriptional activity at target gene promoters. Additionally, we consider how the p53 response is diversified through a variety of mechanisms at the promoter level and beyond to induce context‐specific outcomes in individual cells. These layers of regulation allow p53 to react in a stimulus‐specific manner and fine‐tune its signalling according to the individual needs of a given cell, enabling it to take the right decision on survival or death. |
| Freie Schlagworte: | apoptosis, cell cycle arrest, DNA damage response, p53, post‐transcriptional modifications, protein dynamics, signalling crosstalk, single cell analysis, stochastic gene expression |
| Status: | Verlagsversion |
| URN: | urn:nbn:de:tuda-tuprints-201298 |
| Zusätzliche Informationen: | This article also appears in: State-of-the-Art Reviews |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > Systems Biology of the Stress Response |
| Hinterlegungsdatum: | 22 Dez 2023 13:38 |
| Letzte Änderung: | 28 Dez 2023 07:15 |
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| Suche nach Titel in: | TUfind oder in Google |
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- The guardian's choice: how p53 enables context‐specific decision‐making in individual cells. (deposited 22 Dez 2023 13:38) [Gegenwärtig angezeigt]
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