2024

Buffa, Vanessa ; Meyners, Christian ; Sugiarto, Wisely Oki ; Bauder, Michael ; Gaali, Steffen ; Hausch, Felix (2024)
1,4‐pyrazolyl‐containing SAFit‐analogues are selective FKBP51 inhibitors with improved ligand efficiency and drug‐like profile.
In: ChemMedChem, 19 (17)
doi: 10.1002/cmdc.202400264
Artikel, Bibliographie

Krajczy, Patryk ; Meyners, Christian ; Repity, Maximilian L. ; Hausch, Felix (2024)
Structure‐based design of ultrapotent tricyclic ligands for FK506‐binding proteins.
In: Chemistry – A European Journal, 30 (45)
doi: 10.1002/chem.202401405
Artikel, Bibliographie

Geiger, Thomas M. ; Walz, Michael ; Meyners, Christian ; Kuehn, Angela ; Dreizler, Johannes K. ; Sugiarto, Wisely O. ; Maciel, Edvaldo V. S. ; Zheng, Min ; Lermyte, Frederik ; Hausch, Felix (2024)
Discovery of a potent proteolysis targeting chimera enables targeting the scaffolding functions of FK506‐binding protein 51 (FKBP51).
In: Angewandte Chemie International Edition, 63 (3)
doi: 10.1002/anie.202309706
Artikel, Bibliographie

2023

Deutscher, Robin C. E. ; Safa Karagöz, M. ; Purder, Patrick L. ; Kolos, Jürgen M. ; Meyners, Christian ; Oki Sugiarto, Wisely ; Krajczy, Patryk ; Tebbe, Frederike ; Geiger, Thomas M. ; Ünal, Can ; Hellmich, Ute A. ; Steinert, Michael ; Hausch, Felix (2023)
[4.3.1]Bicyclic FKBP ligands inhibit Legionella Pneumophila infection by LpMip‐dependent and LpMip‐independent mechanisms.
In: ChemBioChem, 24 (21)
doi: 10.1002/cbic.202300442
Artikel, Bibliographie

2022

Lerma Romero, Jorge A. ; Meyners, Christian ; Christmann, Andreas ; Reinbold, Lisa M. ; Charalampidou, Anna ; Hausch, Felix ; Kolmar, Harald (2022)
Binding pocket stabilization by high-throughput screening of yeast display libraries.
In: Frontiers in Molecular Biosciences, 9
doi: 10.3389/fmolb.2022.1023131
Artikel, Bibliographie

Nehls, Thomas ; Heymann, Tim ; Meyners, Christian ; Hausch, Felix ; Lermyte, Frederik (2022)
Fenton-Chemistry-Based Oxidative Modification of Proteins Reflects Their Conformation.
In: International Journal of Molecular Sciences, 22 (18)
doi: 10.3390/ijms22189927
Artikel, Bibliographie

Purder, Patrick L. ; Meyners, Christian ; Krysenko, Sergii ; Funk, Jonathan ; Wohlleben, Wolfgang ; Hausch, Felix (2022)
Mechanism‐Based Design of the First GlnA4‐Specific Inhibitors.
In: ChemBioChem, 23 (19)
doi: 10.1002/cbic.202200312
Artikel, Bibliographie

2021

Kolos, Jürgen M. ; Pomplun, Sebastian ; Jung, Sascha ; Rieß, Benedikt ; Purder, Patrick L. ; Voll, Andreas M. ; Merz, Stephanie ; Gnatzy, Monika ; Geiger, Thomas M. ; Quist-Løkken, Ingrid ; Jatzlau, Jerome ; Knaus, Petra ; Holien, Toril ; Bracher, Andreas ; Meyners, Christian ; Czodrowski, Paul ; Krewald, Vera ; Hausch, Felix (2021)
Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3.1] aza-amides.
In: Chemical Science, 12 (44)
doi: 10.1039/D1SC04638A
Artikel, Bibliographie

2020

Bischoff, Matthias ; Mayer, Peter ; Meyners, Christian ; Hausch, Felix (2020)
Enantioselective synthesis of a tricyclic, sp³‐rich diazatetradecanedione: an amino acid‐based natural product‐like scaffold.
In: Chemistry – A European Journal, 26 (21)
doi: 10.1002/chem.201905144
Artikel, Bibliographie

2019

Geiger, Thomas M. ; Hähle, Andreas ; Merz, Stephanie ; Meyners, Christian ; Tianqi, Mao ; Kolos, Jürgen ; Hausch, Felix (2019)
FKBP51 and FKBP12.6—Novel and tight interactors of Glomulin.
In: PLOS ONE, 14 (9)
doi: 10.1371/journal.pone.0221926
Artikel, Bibliographie

Hähle, Andreas ; Merz, Stephanie ; Meyners, Christian ; Hausch, Felix (2019)
The many faces of FKBP51.
In: Biomolecules, 9 (1)
doi: 10.3390/biom9010035
Artikel, Bibliographie

2018

Juettner, Norbert E. ; Classen, Moritz ; Colin, Felix ; Hoffmann, Sascha B. ; Meyners, Christian ; Pfeifer, Felicitas ; Fuchsbauer, Hans-Lothar (2018)
Features of the transglutaminase-activating metalloprotease from Streptomyces mobaraensis DSM 40847 produced in Escherichia coli.
In: Journal of biotechnology, (281)
Artikel, Bibliographie