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Discovery of a potent proteolysis targeting chimera enables targeting the scaffolding functions of FK506‐binding protein 51 (FKBP51).
In: Angewandte Chemie International Edition, 63 (3)
doi: 10.1002/anie.202309706
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Deutscher, Robin C. E. ; Safa Karagöz, M. ; Purder, Patrick L. ; Kolos, Jürgen M. ; Meyners, Christian ; Oki Sugiarto, Wisely ; Krajczy, Patryk ; Tebbe, Frederike ; Geiger, Thomas M. ; Ünal, Can ; Hellmich, Ute A. ; Steinert, Michael ; Hausch, Felix (2023)
[4.3.1]Bicyclic FKBP ligands inhibit Legionella Pneumophila infection by LpMip‐dependent and LpMip‐independent mechanisms.
In: ChemBioChem, 24 (21)
doi: 10.1002/cbic.202300442
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Kolos, Jürgen M. ; Pomplun, Sebastian ; Jung, Sascha ; Rieß, Benedikt ; Purder, Patrick L. ; Voll, Andreas M. ; Merz, Stephanie ; Gnatzy, Monika ; Geiger, Thomas M. ; Quist-Løkken, Ingrid ; Jatzlau, Jerome ; Knaus, Petra ; Holien, Toril ; Bracher, Andreas ; Meyners, Christian ; Czodrowski, Paul ; Krewald, Vera ; Hausch, Felix (2021)
Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3.1] aza-amides.
In: Chemical Science, 12 (44)
doi: 10.1039/D1SC04638A
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Martinelli, Silvia ; Anderzhanova, Elmira A. ; Bajaj, Thomas ; Wiechmann, Svenja ; Dethloff, Frederik ; Weckmann, Katja ; Heinz, Daniel E. ; Ebert, Tim ; Hartmann, Jakob ; Geiger, Thomas M. ; Döngi, Michael ; Hafner, Kathrin ; Pöhlmann, Max L. ; Jollans, Lee ; Philipsen, Alexandra ; Schmidt, Susanne V. ; Schmidt, Ulrike ; Maccarrone, Giuseppina ; Stein, Valentin ; Hausch, Felix ; Turck, Christoph W. ; Schmidt, Mathias V. ; Gellner, Anne-Kathrin ; Kuster, Bernhard ; Gassen, Nils C. (2021)
Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion.
In: Nature Communications, 12 (1)
doi: 10.1038/s41467-021-24810-5
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Geiger, Thomas M. ; Hähle, Andreas ; Merz, Stephanie ; Meyners, Christian ; Tianqi, Mao ; Kolos, Jürgen ; Hausch, Felix (2019)
FKBP51 and FKBP12.6—Novel and tight interactors of Glomulin.
In: PLOS ONE, 14 (9)
doi: 10.1371/journal.pone.0221926
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