Artikel

Buffa, Vanessa ; Meyners, Christian ; Sugiarto, Wisely Oki ; Bauder, Michael ; Gaali, Steffen ; Hausch, Felix (2024)
1,4‐pyrazolyl‐containing SAFit‐analogues are selective FKBP51 inhibitors with improved ligand efficiency and drug‐like profile.
In: ChemMedChem, 19 (17)
doi: 10.1002/cmdc.202400264
Artikel, Bibliographie

Krajczy, Patryk ; Meyners, Christian ; Repity, Maximilian L. ; Hausch, Felix (2024)
Structure‐based design of ultrapotent tricyclic ligands for FK506‐binding proteins.
In: Chemistry – A European Journal, 30 (45)
doi: 10.1002/chem.202401405
Artikel, Bibliographie

Geiger, Thomas M. ; Walz, Michael ; Meyners, Christian ; Kuehn, Angela ; Dreizler, Johannes K. ; Sugiarto, Wisely O. ; Maciel, Edvaldo V. S. ; Zheng, Min ; Lermyte, Frederik ; Hausch, Felix (2024)
Discovery of a potent proteolysis targeting chimera enables targeting the scaffolding functions of FK506‐binding protein 51 (FKBP51).
In: Angewandte Chemie International Edition, 63 (3)
doi: 10.1002/anie.202309706
Artikel, Bibliographie

Deutscher, Robin C. E. ; Safa Karagöz, M. ; Purder, Patrick L. ; Kolos, Jürgen M. ; Meyners, Christian ; Oki Sugiarto, Wisely ; Krajczy, Patryk ; Tebbe, Frederike ; Geiger, Thomas M. ; Ünal, Can ; Hellmich, Ute A. ; Steinert, Michael ; Hausch, Felix (2023)
[4.3.1]Bicyclic FKBP ligands inhibit Legionella Pneumophila infection by LpMip‐dependent and LpMip‐independent mechanisms.
In: ChemBioChem, 24 (21)
doi: 10.1002/cbic.202300442
Artikel, Bibliographie

Lerma Romero, Jorge A. ; Meyners, Christian ; Christmann, Andreas ; Reinbold, Lisa M. ; Charalampidou, Anna ; Hausch, Felix ; Kolmar, Harald (2022)
Binding pocket stabilization by high-throughput screening of yeast display libraries.
In: Frontiers in Molecular Biosciences, 9
doi: 10.3389/fmolb.2022.1023131
Artikel, Bibliographie

Berthold, Emilia J. ; Ma-Lauer, Yue ; Chakraborty, Ashesh ; Brunn, Brigitte von ; Hilgendorff, Anne ; Hatz, Rudolf ; Behr, Jürgen ; Hausch, Felix ; Staab-Weijnitz, Claudia A. ; Brunn, Albrecht von (2022)
Effects of immunophilin inhibitors and non-immunosuppressive analogs on coronavirus replication in human infection models.
In: Frontiers in Cellular and Infection Microbiology, 12
doi: 10.3389/fcimb.2022.958634
Artikel, Bibliographie

Wedel, Saskia ; Hahnefeld, Lisa ; Alnouri, Mohamad Wessam ; Offermanns, Stefan ; Hausch, Felix ; Geisslinger, Gerd ; Sisignano, Marco (2022)
The FKBP51 Inhibitor SAFit2 Restores the Pain-Relieving C16 Dihydroceramide after Nerve Injury.
In: International Journal of Molecular Sciences, 23 (22)
doi: 10.3390/ijms232214274
Artikel, Bibliographie

Nehls, Thomas ; Heymann, Tim ; Meyners, Christian ; Hausch, Felix ; Lermyte, Frederik (2022)
Fenton-Chemistry-Based Oxidative Modification of Proteins Reflects Their Conformation.
In: International Journal of Molecular Sciences, 22 (18)
doi: 10.3390/ijms22189927
Artikel, Bibliographie

Purder, Patrick L. ; Meyners, Christian ; Krysenko, Sergii ; Funk, Jonathan ; Wohlleben, Wolfgang ; Hausch, Felix (2022)
Mechanism‐Based Design of the First GlnA4‐Specific Inhibitors.
In: ChemBioChem, 23 (19)
doi: 10.1002/cbic.202200312
Artikel, Bibliographie

Kolos, Jürgen M. ; Pomplun, Sebastian ; Jung, Sascha ; Rieß, Benedikt ; Purder, Patrick L. ; Voll, Andreas M. ; Merz, Stephanie ; Gnatzy, Monika ; Geiger, Thomas M. ; Quist-Løkken, Ingrid ; Jatzlau, Jerome ; Knaus, Petra ; Holien, Toril ; Bracher, Andreas ; Meyners, Christian ; Czodrowski, Paul ; Krewald, Vera ; Hausch, Felix (2021)
Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3.1] aza-amides.
In: Chemical Science, 12 (44)
doi: 10.1039/D1SC04638A
Artikel, Bibliographie

Martinelli, Silvia ; Anderzhanova, Elmira A. ; Bajaj, Thomas ; Wiechmann, Svenja ; Dethloff, Frederik ; Weckmann, Katja ; Heinz, Daniel E. ; Ebert, Tim ; Hartmann, Jakob ; Geiger, Thomas M. ; Döngi, Michael ; Hafner, Kathrin ; Pöhlmann, Max L. ; Jollans, Lee ; Philipsen, Alexandra ; Schmidt, Susanne V. ; Schmidt, Ulrike ; Maccarrone, Giuseppina ; Stein, Valentin ; Hausch, Felix ; Turck, Christoph W. ; Schmidt, Mathias V. ; Gellner, Anne-Kathrin ; Kuster, Bernhard ; Gassen, Nils C. (2021)
Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion.
In: Nature Communications, 12 (1)
doi: 10.1038/s41467-021-24810-5
Artikel, Bibliographie

Jagtap, Pravin Kumar Ankush ; Kubelka, Tomáš ; Soni, Komal ; Will, Cindy L. ; Garg, Divita ; Sippel, Claudia ; Kapp, Tobias G. ; Potukuchi, Harish Kumar ; Schorpp, Kenji ; Hadian, Kamyar ; Kessler, Horst ; Lührmann, Reinhard ; Hausch, Felix ; Bach, Thorsten ; Sattler, Michael (2020)
Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly.
In: Nature Communications, 11 (1)
doi: 10.1038/s41467-020-19514-1
Artikel, Bibliographie

Bischoff, Matthias ; Mayer, Peter ; Meyners, Christian ; Hausch, Felix (2020)
Enantioselective synthesis of a tricyclic, sp³‐rich diazatetradecanedione: an amino acid‐based natural product‐like scaffold.
In: Chemistry – A European Journal, 26 (21)
doi: 10.1002/chem.201905144
Artikel, Bibliographie

Schraut, Karla‐Gerlinde ; Kalnytska, Oleksandra ; Lamp, Daniel ; Jastroch, Martin ; Eder, Matthias ; Hausch, Felix ; Gassen, Nils C. ; Moore, Sarah ; Nagaraj, Nagarjuna ; Lopez, Juan P. ; Chen, Alon ; Schmidt, Mathias V. (2020)
Loss of the psychiatric risk factor SLC6A15 is associated with increased metabolic functions in primary hippocampal neurons.
In: European Journal of Neuroscience, 53 (2)
doi: 10.1111/ejn.14990
Artikel, Bibliographie

Geiger, Thomas M. ; Hähle, Andreas ; Merz, Stephanie ; Meyners, Christian ; Tianqi, Mao ; Kolos, Jürgen ; Hausch, Felix (2019)
FKBP51 and FKBP12.6—Novel and tight interactors of Glomulin.
In: PLOS ONE, 14 (9)
doi: 10.1371/journal.pone.0221926
Artikel, Bibliographie

Hähle, Andreas ; Merz, Stephanie ; Meyners, Christian ; Hausch, Felix (2019)
The many faces of FKBP51.
In: Biomolecules, 9 (1)
doi: 10.3390/biom9010035
Artikel, Bibliographie

Kolos, Jürgen M. ; Voll, Andreas M. ; Bauder, Michael ; Hausch, Felix (2018)
FKBP Ligands—Where We Are and Where to Go?
In: Frontiers in Pharmacology, 9
doi: 10.3389/fphar.2018.01425
Artikel, Bibliographie

Konferenzveröffentlichung

Korner, Dominic ; Kramer, Andreas ; Hofmann, Klaus ; Hausch, Felix (2023)
Standalone Area Optimized ASIC Tag Powered and Programmable by Light for Identification of Novel Drug Candidates.
26th International Symposium on Design and Diagnostics of Electronic Circuits and Systems. Tallinn, Estonia (03.05.2023-05.05.2023)
doi: 10.1109/DDECS57882.2023.10139720
Konferenzveröffentlichung, Bibliographie