Acosta, Matias ; Detsch, Rainer ; Grünewald, Alina ; Rojas, Virginia ; Schultheiß, Jan ; Wajda, Aleksandra ; Stark, R. W. ; Narayan, Suman ; Sitarz, Maciej ; Koruza, Jurij ; Boccaccini, Aldo R. (2018)
Cytotoxicity, chemical stability, and surface properties of
ferroelectric ceramics for biomaterials.
In: Journal of the American Ceramic Society, 110
doi: 10.1111/jace.15193
Article
Abstract
Surface chemistry and topo-physical properties determine the interactions of biomaterials with their physiological environment. Ferroelectrics hold great promise as the next generation of scaffolds for tissue repair since they feature tunable surface electrical charges, piezoelectricity, and sensing capabilities. We investigate the topography, wettability, chemical stability, and cytotoxicity in salient ferroelectric systems such as (1-x) (Na1/2Bi1/2)TiO3–xBaTiO3, (1-x)Ba(Zr0.2Ti0.8)O3-x(Ba0.7Ca0.3)TiO3, and Pb(Zr,Ti)O3 to test their suitability as biomaterials. The lead-free ferroelectrics promote in vitro cell viability and proliferation to a considerably high extent. 0.94 mol % (Na1/2Bi1/2)TiO3–0.06 mol% BaTiO3 showed the greatest potential leading to a cell viability of (149 +- 30)% and DNA synthesis of (299 +- 85)% in comparison to the reference. Lead leaching from Pb (Zr,Ti)O3 negatively affected the cultured cells. Wettability and chemical stability are key factors that determine the cytotoxicity of ferroelectrics. These variables have to be considered in the design of novel electroactive scaffolds based on ferroelectric ceramics.
| Item Type: | Article |
|---|---|
| Erschienen: | 2018 |
| Creators: | Acosta, Matias ; Detsch, Rainer ; Grünewald, Alina ; Rojas, Virginia ; Schultheiß, Jan ; Wajda, Aleksandra ; Stark, R. W. ; Narayan, Suman ; Sitarz, Maciej ; Koruza, Jurij ; Boccaccini, Aldo R. |
| Type of entry: | Bibliographie |
| Title: | Cytotoxicity, chemical stability, and surface properties of ferroelectric ceramics for biomaterials |
| Language: | English |
| Date: | 1 January 2018 |
| Publisher: | The American Ceramic Society |
| Journal or Publication Title: | Journal of the American Ceramic Society |
| Volume of the journal: | 110 |
| DOI: | 10.1111/jace.15193 |
| Abstract: | Surface chemistry and topo-physical properties determine the interactions of biomaterials with their physiological environment. Ferroelectrics hold great promise as the next generation of scaffolds for tissue repair since they feature tunable surface electrical charges, piezoelectricity, and sensing capabilities. We investigate the topography, wettability, chemical stability, and cytotoxicity in salient ferroelectric systems such as (1-x) (Na1/2Bi1/2)TiO3–xBaTiO3, (1-x)Ba(Zr0.2Ti0.8)O3-x(Ba0.7Ca0.3)TiO3, and Pb(Zr,Ti)O3 to test their suitability as biomaterials. The lead-free ferroelectrics promote in vitro cell viability and proliferation to a considerably high extent. 0.94 mol % (Na1/2Bi1/2)TiO3–0.06 mol% BaTiO3 showed the greatest potential leading to a cell viability of (149 +- 30)% and DNA synthesis of (299 +- 85)% in comparison to the reference. Lead leaching from Pb (Zr,Ti)O3 negatively affected the cultured cells. Wettability and chemical stability are key factors that determine the cytotoxicity of ferroelectrics. These variables have to be considered in the design of novel electroactive scaffolds based on ferroelectric ceramics. |
| Uncontrolled Keywords: | biocompatible materials, cytotoxicity, ferroelectrics, mouse embryonic fibroblasts, piezoelectric materials |
| Divisions: | 11 Department of Materials and Earth Sciences 11 Department of Materials and Earth Sciences > Material Science 11 Department of Materials and Earth Sciences > Material Science > Nonmetallic-Inorganic Materials |
| Date Deposited: | 03 Nov 2017 14:25 |
| Last Modified: | 03 Jun 2018 21:29 |
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