Helma, Jonas ; Cardoso, M. Cristina ; Muyldermans, Serge ; Leonhardt, Heinrich (2015):
Nanobodies and recombinant binders in cell biology.
In: The Journal of cell biology, 209 (5), pp. 633-644. ISSN 1540-8140,
[Article]
Abstract
Antibodies are key reagents to investigate cellular processes. The development of recombinant antibodies and binders derived from natural protein scaffolds has expanded traditional applications, such as immunofluorescence, binding arrays, and immunoprecipitation. In addition, their small size and high stability in ectopic environments have enabled their use in all areas of cell research, including structural biology, advanced microscopy, and intracellular expression. Understanding these novel reagents as genetic modules that can be integrated into cellular pathways opens up a broad experimental spectrum to monitor and manipulate cellular processes.
| Item Type: | Article |
|---|---|
| Erschienen: | 2015 |
| Creators: | Helma, Jonas ; Cardoso, M. Cristina ; Muyldermans, Serge ; Leonhardt, Heinrich |
| Title: | Nanobodies and recombinant binders in cell biology. |
| Language: | English |
| Abstract: | Antibodies are key reagents to investigate cellular processes. The development of recombinant antibodies and binders derived from natural protein scaffolds has expanded traditional applications, such as immunofluorescence, binding arrays, and immunoprecipitation. In addition, their small size and high stability in ectopic environments have enabled their use in all areas of cell research, including structural biology, advanced microscopy, and intracellular expression. Understanding these novel reagents as genetic modules that can be integrated into cellular pathways opens up a broad experimental spectrum to monitor and manipulate cellular processes. |
| Journal or Publication Title: | The Journal of cell biology |
| Volume of the journal: | 209 |
| Issue Number: | 5 |
| Divisions: | 10 Department of Biology 10 Department of Biology > Cell Biology and Epigenetics |
| Date Deposited: | 15 Jun 2015 12:47 |
| PPN: | |
| Export: | |
| Suche nach Titel in: | TUfind oder in Google |
 |
Send an inquiry |
Options (only for editors)
 |
Show editorial Details |
Drucken
Impressum