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Nanobodies and recombinant binders in cell biology.

Helma, Jonas ; Cardoso, M. Cristina ; Muyldermans, Serge ; Leonhardt, Heinrich (2015)
Nanobodies and recombinant binders in cell biology.
In: The Journal of cell biology, 209 (5)
Article, Bibliographie

Abstract

Antibodies are key reagents to investigate cellular processes. The development of recombinant antibodies and binders derived from natural protein scaffolds has expanded traditional applications, such as immunofluorescence, binding arrays, and immunoprecipitation. In addition, their small size and high stability in ectopic environments have enabled their use in all areas of cell research, including structural biology, advanced microscopy, and intracellular expression. Understanding these novel reagents as genetic modules that can be integrated into cellular pathways opens up a broad experimental spectrum to monitor and manipulate cellular processes.

Item Type: Article
Erschienen: 2015
Creators: Helma, Jonas ; Cardoso, M. Cristina ; Muyldermans, Serge ; Leonhardt, Heinrich
Type of entry: Bibliographie
Title: Nanobodies and recombinant binders in cell biology.
Language: English
Date: 2015
Journal or Publication Title: The Journal of cell biology
Volume of the journal: 209
Issue Number: 5
Abstract:

Antibodies are key reagents to investigate cellular processes. The development of recombinant antibodies and binders derived from natural protein scaffolds has expanded traditional applications, such as immunofluorescence, binding arrays, and immunoprecipitation. In addition, their small size and high stability in ectopic environments have enabled their use in all areas of cell research, including structural biology, advanced microscopy, and intracellular expression. Understanding these novel reagents as genetic modules that can be integrated into cellular pathways opens up a broad experimental spectrum to monitor and manipulate cellular processes.

Divisions: 10 Department of Biology
10 Department of Biology > Cell Biology and Epigenetics
Date Deposited: 15 Jun 2015 12:47
Last Modified: 15 Jun 2015 12:47
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