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Radioactive Beams for Image-Guided Particle Therapy: The BARB Experiment at GSI

Boscolo, Daria ; Kostyleva, Daria ; Safari, Mohammad Javad ; Anagnostatou, Vasiliki ; Äystö, Juha ; Bagchi, Soumya ; Binder, Tim ; Dedes, Georgios ; Dendooven, Peter ; Dickel, Timo ; Drozd, Vasyl ; Franczack, Bernhard ; Geissel, Hans ; Gianoli, Chiara ; Graeff, Christian ; Grahn, Tuomas ; Greiner, Florian ; Haettner, Emma ; Haghani, Roghieh ; Harakeh, Muhsin N. ; Horst, Felix ; Hornung, Christine ; Hucka, Jan-Paul ; Kalantar-Nayestanaki, Nasser ; Kazantseva, Erika ; Kindler, Birgit ; Knöbel, Ronja ; Kuzminchuk-Feuerstein, Natalia ; Lommel, Bettina ; Mukha, Ivan ; Nociforo, Chiara ; Ishikawa, Shunki ; Lovatti, Giulio ; Nitta, Munetaka ; Ozoemelam, Ikechi ; Pietri, Stephane ; Plaß, Wolfgang R. ; Prochazka, Andrej ; Purushothaman, Sivaji ; Reidel, Claire-Anne ; Roesch, Heidi ; Schirru, Fabio ; Schuy, Christoph ; Sokol, Olga ; Steinsberger, Timo ; Tanaka, Yoshiki K. ; Tanihata, Isao ; Thirolf, Peter ; Tinganelli, Walter ; Voss, Bernd ; Weber, Uli ; Weick, Helmut ; Winfield, John S. ; Winkler, Martin ; Zhao, Jianwei ; Scheidenberger, Christoph ; Parodi, Katia ; Durante, Marco (2021)
Radioactive Beams for Image-Guided Particle Therapy: The BARB Experiment at GSI.
In: Frontiers in Oncology, 11
doi: 10.3389/fonc.2021.737050
Article, Bibliographie

This is the latest version of this item.

Abstract

Several techniques are under development for image-guidance in particle therapy. Positron (β⁺) emission tomography (PET) is in use since many years, because accelerated ions generate positron-emitting isotopes by nuclear fragmentation in the human body. In heavy ion therapy, a major part of the PET signals is produced by β⁺-emitters generated via projectile fragmentation. A much higher intensity for the PET signal can be obtained using β⁺-radioactive beams directly for treatment. This idea has always been hampered by the low intensity of the secondary beams, produced by fragmentation of the primary, stable beams. With the intensity upgrade of the SIS-18 synchrotron and the isotopic separation with the fragment separator FRS in the FAIR-phase-0 in Darmstadt, it is now possible to reach radioactive ion beams with sufficient intensity to treat a tumor in small animals. This was the motivation of the BARB (Biomedical Applications of Radioactive ion Beams) experiment that is ongoing at GSI in Darmstadt. This paper will present the plans and instruments developed by the BARB collaboration for testing the use of radioactive beams in cancer therapy.

Item Type: Article
Erschienen: 2021
Creators: Boscolo, Daria ; Kostyleva, Daria ; Safari, Mohammad Javad ; Anagnostatou, Vasiliki ; Äystö, Juha ; Bagchi, Soumya ; Binder, Tim ; Dedes, Georgios ; Dendooven, Peter ; Dickel, Timo ; Drozd, Vasyl ; Franczack, Bernhard ; Geissel, Hans ; Gianoli, Chiara ; Graeff, Christian ; Grahn, Tuomas ; Greiner, Florian ; Haettner, Emma ; Haghani, Roghieh ; Harakeh, Muhsin N. ; Horst, Felix ; Hornung, Christine ; Hucka, Jan-Paul ; Kalantar-Nayestanaki, Nasser ; Kazantseva, Erika ; Kindler, Birgit ; Knöbel, Ronja ; Kuzminchuk-Feuerstein, Natalia ; Lommel, Bettina ; Mukha, Ivan ; Nociforo, Chiara ; Ishikawa, Shunki ; Lovatti, Giulio ; Nitta, Munetaka ; Ozoemelam, Ikechi ; Pietri, Stephane ; Plaß, Wolfgang R. ; Prochazka, Andrej ; Purushothaman, Sivaji ; Reidel, Claire-Anne ; Roesch, Heidi ; Schirru, Fabio ; Schuy, Christoph ; Sokol, Olga ; Steinsberger, Timo ; Tanaka, Yoshiki K. ; Tanihata, Isao ; Thirolf, Peter ; Tinganelli, Walter ; Voss, Bernd ; Weber, Uli ; Weick, Helmut ; Winfield, John S. ; Winkler, Martin ; Zhao, Jianwei ; Scheidenberger, Christoph ; Parodi, Katia ; Durante, Marco
Type of entry: Bibliographie
Title: Radioactive Beams for Image-Guided Particle Therapy: The BARB Experiment at GSI
Language: English
Date: 19 August 2021
Place of Publication: Lausanne
Publisher: Frontiers Media S.A.
Journal or Publication Title: Frontiers in Oncology
Volume of the journal: 11
Collation: 15 Seiten
DOI: 10.3389/fonc.2021.737050
Corresponding Links:
Abstract:

Several techniques are under development for image-guidance in particle therapy. Positron (β⁺) emission tomography (PET) is in use since many years, because accelerated ions generate positron-emitting isotopes by nuclear fragmentation in the human body. In heavy ion therapy, a major part of the PET signals is produced by β⁺-emitters generated via projectile fragmentation. A much higher intensity for the PET signal can be obtained using β⁺-radioactive beams directly for treatment. This idea has always been hampered by the low intensity of the secondary beams, produced by fragmentation of the primary, stable beams. With the intensity upgrade of the SIS-18 synchrotron and the isotopic separation with the fragment separator FRS in the FAIR-phase-0 in Darmstadt, it is now possible to reach radioactive ion beams with sufficient intensity to treat a tumor in small animals. This was the motivation of the BARB (Biomedical Applications of Radioactive ion Beams) experiment that is ongoing at GSI in Darmstadt. This paper will present the plans and instruments developed by the BARB collaboration for testing the use of radioactive beams in cancer therapy.

Uncontrolled Keywords: particle therapy, radioactive ion beams, carbon ions, oxygen ions, PET
Identification Number: Artikel-ID: 737050
Additional Information:

This article is part of the Research Topic: Image-guided Particle Therapy

Specialty section: This article was submitted to Cancer Imaging and Image-directed Interventions, a section of the journal Frontiers in Oncology

Classification DDC: 500 Science and mathematics > 530 Physics
600 Technology, medicine, applied sciences > 610 Medicine and health
Divisions: 05 Department of Physics
05 Department of Physics > Institute for Condensed Matter Physics
05 Department of Physics > Institute of Nuclear Physics
05 Department of Physics > Institute of Nuclear Physics > Experimentelle Kernphysik
Date Deposited: 19 Mar 2024 10:34
Last Modified: 19 Mar 2024 10:34
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