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Radioactive Beams for Image-Guided Particle Therapy: The BARB Experiment at GSI

Boscolo, Daria ; Kostyleva, Daria ; Safari, Mohammad Javad ; Anagnostatou, Vasiliki ; Äystö, Juha ; Bagchi, Soumya ; Binder, Tim ; Dedes, Georgios ; Dendooven, Peter ; Dickel, Timo ; Drozd, Vasyl ; Franczack, Bernhard ; Geissel, Hans ; Gianoli, Chiara ; Graeff, Christian ; Grahn, Tuomas ; Greiner, Florian ; Haettner, Emma ; Haghani, Roghieh ; Harakeh, Muhsin N. ; Horst, Felix ; Hornung, Christine ; Hucka, Jan-Paul ; Kalantar-Nayestanaki, Nasser ; Kazantseva, Erika ; Kindler, Birgit ; Knöbel, Ronja ; Kuzminchuk-Feuerstein, Natalia ; Lommel, Bettina ; Mukha, Ivan ; Nociforo, Chiara ; Ishikawa, Shunki ; Lovatti, Giulio ; Nitta, Munetaka ; Ozoemelam, Ikechi ; Pietri, Stephane ; Plaß, Wolfgang R. ; Prochazka, Andrej ; Purushothaman, Sivaji ; Reidel, Claire-Anne ; Roesch, Heidi ; Schirru, Fabio ; Schuy, Christoph ; Sokol, Olga ; Steinsberger, Timo ; Tanaka, Yoshiki K. ; Tanihata, Isao ; Thirolf, Peter ; Tinganelli, Walter ; Voss, Bernd ; Weber, Uli ; Weick, Helmut ; Winfield, John S. ; Winkler, Martin ; Zhao, Jianwei ; Scheidenberger, Christoph ; Parodi, Katia ; Durante, Marco (2021)
Radioactive Beams for Image-Guided Particle Therapy: The BARB Experiment at GSI.
In: Frontiers in Oncology, 11
doi: 10.3389/fonc.2021.737050
Artikel, Bibliographie

Dies ist die neueste Version dieses Eintrags.

Kurzbeschreibung (Abstract)

Several techniques are under development for image-guidance in particle therapy. Positron (β⁺) emission tomography (PET) is in use since many years, because accelerated ions generate positron-emitting isotopes by nuclear fragmentation in the human body. In heavy ion therapy, a major part of the PET signals is produced by β⁺-emitters generated via projectile fragmentation. A much higher intensity for the PET signal can be obtained using β⁺-radioactive beams directly for treatment. This idea has always been hampered by the low intensity of the secondary beams, produced by fragmentation of the primary, stable beams. With the intensity upgrade of the SIS-18 synchrotron and the isotopic separation with the fragment separator FRS in the FAIR-phase-0 in Darmstadt, it is now possible to reach radioactive ion beams with sufficient intensity to treat a tumor in small animals. This was the motivation of the BARB (Biomedical Applications of Radioactive ion Beams) experiment that is ongoing at GSI in Darmstadt. This paper will present the plans and instruments developed by the BARB collaboration for testing the use of radioactive beams in cancer therapy.

Typ des Eintrags: Artikel
Erschienen: 2021
Autor(en): Boscolo, Daria ; Kostyleva, Daria ; Safari, Mohammad Javad ; Anagnostatou, Vasiliki ; Äystö, Juha ; Bagchi, Soumya ; Binder, Tim ; Dedes, Georgios ; Dendooven, Peter ; Dickel, Timo ; Drozd, Vasyl ; Franczack, Bernhard ; Geissel, Hans ; Gianoli, Chiara ; Graeff, Christian ; Grahn, Tuomas ; Greiner, Florian ; Haettner, Emma ; Haghani, Roghieh ; Harakeh, Muhsin N. ; Horst, Felix ; Hornung, Christine ; Hucka, Jan-Paul ; Kalantar-Nayestanaki, Nasser ; Kazantseva, Erika ; Kindler, Birgit ; Knöbel, Ronja ; Kuzminchuk-Feuerstein, Natalia ; Lommel, Bettina ; Mukha, Ivan ; Nociforo, Chiara ; Ishikawa, Shunki ; Lovatti, Giulio ; Nitta, Munetaka ; Ozoemelam, Ikechi ; Pietri, Stephane ; Plaß, Wolfgang R. ; Prochazka, Andrej ; Purushothaman, Sivaji ; Reidel, Claire-Anne ; Roesch, Heidi ; Schirru, Fabio ; Schuy, Christoph ; Sokol, Olga ; Steinsberger, Timo ; Tanaka, Yoshiki K. ; Tanihata, Isao ; Thirolf, Peter ; Tinganelli, Walter ; Voss, Bernd ; Weber, Uli ; Weick, Helmut ; Winfield, John S. ; Winkler, Martin ; Zhao, Jianwei ; Scheidenberger, Christoph ; Parodi, Katia ; Durante, Marco
Art des Eintrags: Bibliographie
Titel: Radioactive Beams for Image-Guided Particle Therapy: The BARB Experiment at GSI
Sprache: Englisch
Publikationsjahr: 19 August 2021
Ort: Lausanne
Verlag: Frontiers Media S.A.
Titel der Zeitschrift, Zeitung oder Schriftenreihe: Frontiers in Oncology
Jahrgang/Volume einer Zeitschrift: 11
Kollation: 15 Seiten
DOI: 10.3389/fonc.2021.737050
Zugehörige Links:
Kurzbeschreibung (Abstract):

Several techniques are under development for image-guidance in particle therapy. Positron (β⁺) emission tomography (PET) is in use since many years, because accelerated ions generate positron-emitting isotopes by nuclear fragmentation in the human body. In heavy ion therapy, a major part of the PET signals is produced by β⁺-emitters generated via projectile fragmentation. A much higher intensity for the PET signal can be obtained using β⁺-radioactive beams directly for treatment. This idea has always been hampered by the low intensity of the secondary beams, produced by fragmentation of the primary, stable beams. With the intensity upgrade of the SIS-18 synchrotron and the isotopic separation with the fragment separator FRS in the FAIR-phase-0 in Darmstadt, it is now possible to reach radioactive ion beams with sufficient intensity to treat a tumor in small animals. This was the motivation of the BARB (Biomedical Applications of Radioactive ion Beams) experiment that is ongoing at GSI in Darmstadt. This paper will present the plans and instruments developed by the BARB collaboration for testing the use of radioactive beams in cancer therapy.

Freie Schlagworte: particle therapy, radioactive ion beams, carbon ions, oxygen ions, PET
ID-Nummer: Artikel-ID: 737050
Zusätzliche Informationen:

This article is part of the Research Topic: Image-guided Particle Therapy

Specialty section: This article was submitted to Cancer Imaging and Image-directed Interventions, a section of the journal Frontiers in Oncology

Sachgruppe der Dewey Dezimalklassifikatin (DDC): 500 Naturwissenschaften und Mathematik > 530 Physik
600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin, Gesundheit
Fachbereich(e)/-gebiet(e): 05 Fachbereich Physik
05 Fachbereich Physik > Institut für Physik Kondensierter Materie (IPKM)
05 Fachbereich Physik > Institut für Kernphysik
05 Fachbereich Physik > Institut für Kernphysik > Experimentelle Kernphysik
Hinterlegungsdatum: 19 Mär 2024 10:34
Letzte Änderung: 19 Mär 2024 10:34
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