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MeCP2 and Chromatin Compartmentalization

Schmidt, Annika ; Zhang, Hui ; Cardoso, M. Cristina (2020)
MeCP2 and Chromatin Compartmentalization.
In: Cells, 2020, 9 (4)
doi: 10.25534/tuprints-00013360
Article, Secondary publication

Abstract

Methyl-CpG binding protein 2 (MeCP2) is a multifunctional epigenetic reader playing a role in transcriptional regulation and chromatin structure, which was linked to Rett syndrome in humans. Here, we focus on its isoforms and functional domains, interactions, modifications and mutations found in Rett patients. Finally, we address how these properties regulate and mediate the ability of MeCP2 to orchestrate chromatin compartmentalization and higher order genome architecture.

Item Type: Article
Erschienen: 2020
Creators: Schmidt, Annika ; Zhang, Hui ; Cardoso, M. Cristina
Type of entry: Secondary publication
Title: MeCP2 and Chromatin Compartmentalization
Language: English
Date: 2020
Year of primary publication: 2020
Publisher: MDPI
Journal or Publication Title: Cells
Volume of the journal: 9
Issue Number: 4
DOI: 10.25534/tuprints-00013360
URL / URN: https://doi.org/10.3390/cells9040878
Origin: Secondary publication via sponsored Golden Open Access
Abstract:

Methyl-CpG binding protein 2 (MeCP2) is a multifunctional epigenetic reader playing a role in transcriptional regulation and chromatin structure, which was linked to Rett syndrome in humans. Here, we focus on its isoforms and functional domains, interactions, modifications and mutations found in Rett patients. Finally, we address how these properties regulate and mediate the ability of MeCP2 to orchestrate chromatin compartmentalization and higher order genome architecture.

URN: urn:nbn:de:tuda-tuprints-133604
Classification DDC: 500 Science and mathematics > 570 Life sciences, biology
Divisions: 10 Department of Biology
10 Department of Biology > Cell Biology and Epigenetics
Date Deposited: 25 Aug 2020 09:22
Last Modified: 01 Sep 2020 05:19
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