Acosta, Matias ; Detsch, Rainer ; Grünewald, Alina ; Rojas, Virginia ; Schultheiß, Jan ; Wajda, Aleksandra ; Stark, R. W. ; Narayan, Suman ; Sitarz, Maciej ; Koruza, Jurij ; Boccaccini, Aldo R. (2018)
Cytotoxicity, chemical stability, and surface properties of
ferroelectric ceramics for biomaterials.
In: Journal of the American Ceramic Society, 110
doi: 10.1111/jace.15193
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Surface chemistry and topo-physical properties determine the interactions of biomaterials with their physiological environment. Ferroelectrics hold great promise as the next generation of scaffolds for tissue repair since they feature tunable surface electrical charges, piezoelectricity, and sensing capabilities. We investigate the topography, wettability, chemical stability, and cytotoxicity in salient ferroelectric systems such as (1-x) (Na1/2Bi1/2)TiO3–xBaTiO3, (1-x)Ba(Zr0.2Ti0.8)O3-x(Ba0.7Ca0.3)TiO3, and Pb(Zr,Ti)O3 to test their suitability as biomaterials. The lead-free ferroelectrics promote in vitro cell viability and proliferation to a considerably high extent. 0.94 mol % (Na1/2Bi1/2)TiO3–0.06 mol% BaTiO3 showed the greatest potential leading to a cell viability of (149 +- 30)% and DNA synthesis of (299 +- 85)% in comparison to the reference. Lead leaching from Pb (Zr,Ti)O3 negatively affected the cultured cells. Wettability and chemical stability are key factors that determine the cytotoxicity of ferroelectrics. These variables have to be considered in the design of novel electroactive scaffolds based on ferroelectric ceramics.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2018 |
| Autor(en): | Acosta, Matias ; Detsch, Rainer ; Grünewald, Alina ; Rojas, Virginia ; Schultheiß, Jan ; Wajda, Aleksandra ; Stark, R. W. ; Narayan, Suman ; Sitarz, Maciej ; Koruza, Jurij ; Boccaccini, Aldo R. |
| Art des Eintrags: | Bibliographie |
| Titel: | Cytotoxicity, chemical stability, and surface properties of ferroelectric ceramics for biomaterials |
| Sprache: | Englisch |
| Publikationsjahr: | 1 Januar 2018 |
| Verlag: | The American Ceramic Society |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Journal of the American Ceramic Society |
| Jahrgang/Volume einer Zeitschrift: | 110 |
| DOI: | 10.1111/jace.15193 |
| Kurzbeschreibung (Abstract): | Surface chemistry and topo-physical properties determine the interactions of biomaterials with their physiological environment. Ferroelectrics hold great promise as the next generation of scaffolds for tissue repair since they feature tunable surface electrical charges, piezoelectricity, and sensing capabilities. We investigate the topography, wettability, chemical stability, and cytotoxicity in salient ferroelectric systems such as (1-x) (Na1/2Bi1/2)TiO3–xBaTiO3, (1-x)Ba(Zr0.2Ti0.8)O3-x(Ba0.7Ca0.3)TiO3, and Pb(Zr,Ti)O3 to test their suitability as biomaterials. The lead-free ferroelectrics promote in vitro cell viability and proliferation to a considerably high extent. 0.94 mol % (Na1/2Bi1/2)TiO3–0.06 mol% BaTiO3 showed the greatest potential leading to a cell viability of (149 +- 30)% and DNA synthesis of (299 +- 85)% in comparison to the reference. Lead leaching from Pb (Zr,Ti)O3 negatively affected the cultured cells. Wettability and chemical stability are key factors that determine the cytotoxicity of ferroelectrics. These variables have to be considered in the design of novel electroactive scaffolds based on ferroelectric ceramics. |
| Freie Schlagworte: | biocompatible materials, cytotoxicity, ferroelectrics, mouse embryonic fibroblasts, piezoelectric materials |
| Fachbereich(e)/-gebiet(e): | 11 Fachbereich Material- und Geowissenschaften 11 Fachbereich Material- und Geowissenschaften > Materialwissenschaft 11 Fachbereich Material- und Geowissenschaften > Materialwissenschaft > Fachgebiet Nichtmetallisch-Anorganische Werkstoffe |
| Hinterlegungsdatum: | 03 Nov 2017 14:25 |
| Letzte Änderung: | 03 Jun 2018 21:29 |
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