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Cytotoxicity, chemical stability, and surface properties of ferroelectric ceramics for biomaterials

Acosta, Matias and Detsch, Rainer and Grünewald, Alina and Rojas, Virginia and Schultheiß, Jan and Wajda, Aleksandra and Stark, R. W. and Narayan, Suman and Sitarz, Maciej and Koruza, Jurij and Boccaccini, Aldo R. (2018):
Cytotoxicity, chemical stability, and surface properties of ferroelectric ceramics for biomaterials.
In: Journal of the American Ceramic Society, The American Ceramic Society, pp. 440-449, 110, ISSN 00027820,
DOI: 10.1111/jace.15193,
[Article]

Abstract

Surface chemistry and topo-physical properties determine the interactions of biomaterials with their physiological environment. Ferroelectrics hold great promise as the next generation of scaffolds for tissue repair since they feature tunable surface electrical charges, piezoelectricity, and sensing capabilities. We investigate the topography, wettability, chemical stability, and cytotoxicity in salient ferroelectric systems such as (1-x) (Na1/2Bi1/2)TiO3–xBaTiO3, (1-x)Ba(Zr0.2Ti0.8)O3-x(Ba0.7Ca0.3)TiO3, and Pb(Zr,Ti)O3 to test their suitability as biomaterials. The lead-free ferroelectrics promote in vitro cell viability and proliferation to a considerably high extent. 0.94 mol % (Na1/2Bi1/2)TiO3–0.06 mol% BaTiO3 showed the greatest potential leading to a cell viability of (149 +- 30)% and DNA synthesis of (299 +- 85)% in comparison to the reference. Lead leaching from Pb (Zr,Ti)O3 negatively affected the cultured cells. Wettability and chemical stability are key factors that determine the cytotoxicity of ferroelectrics. These variables have to be considered in the design of novel electroactive scaffolds based on ferroelectric ceramics.

Item Type: Article
Erschienen: 2018
Creators: Acosta, Matias and Detsch, Rainer and Grünewald, Alina and Rojas, Virginia and Schultheiß, Jan and Wajda, Aleksandra and Stark, R. W. and Narayan, Suman and Sitarz, Maciej and Koruza, Jurij and Boccaccini, Aldo R.
Title: Cytotoxicity, chemical stability, and surface properties of ferroelectric ceramics for biomaterials
Language: English
Abstract:

Surface chemistry and topo-physical properties determine the interactions of biomaterials with their physiological environment. Ferroelectrics hold great promise as the next generation of scaffolds for tissue repair since they feature tunable surface electrical charges, piezoelectricity, and sensing capabilities. We investigate the topography, wettability, chemical stability, and cytotoxicity in salient ferroelectric systems such as (1-x) (Na1/2Bi1/2)TiO3–xBaTiO3, (1-x)Ba(Zr0.2Ti0.8)O3-x(Ba0.7Ca0.3)TiO3, and Pb(Zr,Ti)O3 to test their suitability as biomaterials. The lead-free ferroelectrics promote in vitro cell viability and proliferation to a considerably high extent. 0.94 mol % (Na1/2Bi1/2)TiO3–0.06 mol% BaTiO3 showed the greatest potential leading to a cell viability of (149 +- 30)% and DNA synthesis of (299 +- 85)% in comparison to the reference. Lead leaching from Pb (Zr,Ti)O3 negatively affected the cultured cells. Wettability and chemical stability are key factors that determine the cytotoxicity of ferroelectrics. These variables have to be considered in the design of novel electroactive scaffolds based on ferroelectric ceramics.

Journal or Publication Title: Journal of the American Ceramic Society
Volume: 110
Publisher: The American Ceramic Society
Uncontrolled Keywords: biocompatible materials, cytotoxicity, ferroelectrics, mouse embryonic fibroblasts, piezoelectric materials
Divisions: 11 Department of Materials and Earth Sciences
11 Department of Materials and Earth Sciences > Material Science
11 Department of Materials and Earth Sciences > Material Science > Nonmetallic-Inorganic Materials
Date Deposited: 03 Nov 2017 14:25
DOI: 10.1111/jace.15193
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