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Nanobodies and recombinant binders in cell biology.

Helma, Jonas and Cardoso, M. Cristina and Muyldermans, Serge and Leonhardt, Heinrich (2015):
Nanobodies and recombinant binders in cell biology.
In: The Journal of cell biology, pp. 633-644, 209, (5), ISSN 1540-8140,
[Article]

Abstract

Antibodies are key reagents to investigate cellular processes. The development of recombinant antibodies and binders derived from natural protein scaffolds has expanded traditional applications, such as immunofluorescence, binding arrays, and immunoprecipitation. In addition, their small size and high stability in ectopic environments have enabled their use in all areas of cell research, including structural biology, advanced microscopy, and intracellular expression. Understanding these novel reagents as genetic modules that can be integrated into cellular pathways opens up a broad experimental spectrum to monitor and manipulate cellular processes.

Item Type: Article
Erschienen: 2015
Creators: Helma, Jonas and Cardoso, M. Cristina and Muyldermans, Serge and Leonhardt, Heinrich
Title: Nanobodies and recombinant binders in cell biology.
Language: English
Abstract:

Antibodies are key reagents to investigate cellular processes. The development of recombinant antibodies and binders derived from natural protein scaffolds has expanded traditional applications, such as immunofluorescence, binding arrays, and immunoprecipitation. In addition, their small size and high stability in ectopic environments have enabled their use in all areas of cell research, including structural biology, advanced microscopy, and intracellular expression. Understanding these novel reagents as genetic modules that can be integrated into cellular pathways opens up a broad experimental spectrum to monitor and manipulate cellular processes.

Journal or Publication Title: The Journal of cell biology
Volume: 209
Number: 5
Divisions: 10 Department of Biology
10 Department of Biology > Cell Biology and Epigenetics
Date Deposited: 15 Jun 2015 12:47
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