Helma, Jonas ; Cardoso, M. Cristina ; Muyldermans, Serge ; Leonhardt, Heinrich (2015)
Nanobodies and recombinant binders in cell biology.
In: The Journal of cell biology, 209 (5)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Antibodies are key reagents to investigate cellular processes. The development of recombinant antibodies and binders derived from natural protein scaffolds has expanded traditional applications, such as immunofluorescence, binding arrays, and immunoprecipitation. In addition, their small size and high stability in ectopic environments have enabled their use in all areas of cell research, including structural biology, advanced microscopy, and intracellular expression. Understanding these novel reagents as genetic modules that can be integrated into cellular pathways opens up a broad experimental spectrum to monitor and manipulate cellular processes.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2015 |
| Autor(en): | Helma, Jonas ; Cardoso, M. Cristina ; Muyldermans, Serge ; Leonhardt, Heinrich |
| Art des Eintrags: | Bibliographie |
| Titel: | Nanobodies and recombinant binders in cell biology. |
| Sprache: | Englisch |
| Publikationsjahr: | 2015 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | The Journal of cell biology |
| Jahrgang/Volume einer Zeitschrift: | 209 |
| (Heft-)Nummer: | 5 |
| Kurzbeschreibung (Abstract): | Antibodies are key reagents to investigate cellular processes. The development of recombinant antibodies and binders derived from natural protein scaffolds has expanded traditional applications, such as immunofluorescence, binding arrays, and immunoprecipitation. In addition, their small size and high stability in ectopic environments have enabled their use in all areas of cell research, including structural biology, advanced microscopy, and intracellular expression. Understanding these novel reagents as genetic modules that can be integrated into cellular pathways opens up a broad experimental spectrum to monitor and manipulate cellular processes. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > Cell Biology and Epigenetics |
| Hinterlegungsdatum: | 15 Jun 2015 12:47 |
| Letzte Änderung: | 15 Jun 2015 12:47 |
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