Lynagh, Timothy ; Beech, Robin N. ; Lalande, Maryline J. ; Keller, Kevin ; Cromer, Brett A. ; Wolstenholme, Adrian J. ; Laube, Bodo (2015)
Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels.
In: Scientific reports, 24 (5)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Glutamate is an indispensable neurotransmitter, triggering postsynaptic signals upon recognition by postsynaptic receptors. We questioned the phylogenetic position and the molecular details of when and where glutamate recognition arose in the glutamate-gated chloride channels. Experiments revealed that glutamate recognition requires an arginine residue in the base of the binding site, which originated at least three distinct times according to phylogenetic analysis. Most remarkably, the arginine emerged on the principal face of the binding site in the Lophotrochozoan lineage, but 65 amino acids upstream, on the complementary face, in the Ecdysozoan lineage. This combined experimental and computational approach throws new light on the evolution of synaptic signalling.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2015 |
| Autor(en): | Lynagh, Timothy ; Beech, Robin N. ; Lalande, Maryline J. ; Keller, Kevin ; Cromer, Brett A. ; Wolstenholme, Adrian J. ; Laube, Bodo |
| Art des Eintrags: | Bibliographie |
| Titel: | Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels. |
| Sprache: | Englisch |
| Publikationsjahr: | 2015 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Scientific reports |
| Jahrgang/Volume einer Zeitschrift: | 24 |
| (Heft-)Nummer: | 5 |
| Kurzbeschreibung (Abstract): | Glutamate is an indispensable neurotransmitter, triggering postsynaptic signals upon recognition by postsynaptic receptors. We questioned the phylogenetic position and the molecular details of when and where glutamate recognition arose in the glutamate-gated chloride channels. Experiments revealed that glutamate recognition requires an arginine residue in the base of the binding site, which originated at least three distinct times according to phylogenetic analysis. Most remarkably, the arginine emerged on the principal face of the binding site in the Lophotrochozoan lineage, but 65 amino acids upstream, on the complementary face, in the Ecdysozoan lineage. This combined experimental and computational approach throws new light on the evolution of synaptic signalling. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > Neurophysiologie und neurosensorische Systeme |
| Hinterlegungsdatum: | 03 Mär 2015 10:19 |
| Letzte Änderung: | 05 Mär 2019 06:48 |
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