Klann, M. ; Koeppl, H. (2012)
Spatial simulations in systems biology: from molecules to cells.
In: International journal of molecular sciences, 13 (6)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Cells are highly organized objects containing millions of molecules. Each biomolecule has a specific shape in order to interact with others in the complex machinery. Spatial dynamics emerge in this system on length and time scales which can not yet be modeled with full atomic detail. This review gives an overview of methods which can be used to simulate the complete cell at least with molecular detail, especially Brownian dynamics simulations. Such simulations require correct implementation of the diffusion-controlled reaction scheme occurring on this level. Implementations and applications of spatial simulations are presented, and finally it is discussed how the atomic level can be included for instance in multi-scale simulation methods.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2012 |
| Autor(en): | Klann, M. ; Koeppl, H. |
| Art des Eintrags: | Bibliographie |
| Titel: | Spatial simulations in systems biology: from molecules to cells |
| Sprache: | Englisch |
| Publikationsjahr: | Januar 2012 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | International journal of molecular sciences |
| Jahrgang/Volume einer Zeitschrift: | 13 |
| (Heft-)Nummer: | 6 |
| URL / URN: | http://www.mdpi.com/1422-0067/13/6/7798 |
| Zugehörige Links: | |
| Kurzbeschreibung (Abstract): | Cells are highly organized objects containing millions of molecules. Each biomolecule has a specific shape in order to interact with others in the complex machinery. Spatial dynamics emerge in this system on length and time scales which can not yet be modeled with full atomic detail. This review gives an overview of methods which can be used to simulate the complete cell at least with molecular detail, especially Brownian dynamics simulations. Such simulations require correct implementation of the diffusion-controlled reaction scheme occurring on this level. Implementations and applications of spatial simulations are presented, and finally it is discussed how the atomic level can be included for instance in multi-scale simulation methods. |
| Fachbereich(e)/-gebiet(e): | 18 Fachbereich Elektrotechnik und Informationstechnik 18 Fachbereich Elektrotechnik und Informationstechnik > Institut für Nachrichtentechnik > Bioinspirierte Kommunikationssysteme 18 Fachbereich Elektrotechnik und Informationstechnik > Institut für Nachrichtentechnik |
| Hinterlegungsdatum: | 04 Apr 2014 12:50 |
| Letzte Änderung: | 23 Sep 2021 14:31 |
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