Layer, Paul G. ; Rothermel, A. ; Willbold, E. (1998)
Inductive effects of the retinal pigmented epithelium (RPE) on histogenesis of the avian retina as revealed by retinospheroid technology.
In: Seminars in cell & developmental biology, 9 (3)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
During eye formation, inductive phenomena occurring between retinal pigmented epithelium (RPE) and retina are not well understood. After briefly summarizing the normal development of retina and RPE, we present three-dimensional in vitro models of the chick embryonic retina which allows elucidation of RPE-retina interactions. In such retinospheroids, a complete arrangement of layers is achieved, provided that dispersed retinal cells are: (1) young enough; and (2) reaggregated on a monolayer of RPE. Thereby, the RPE extends cell proliferation, while differentiation is much delayed. These findings assign to the RPE a decisive role for the genesis and regeneration of a vertebrate retina.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 1998 |
| Autor(en): | Layer, Paul G. ; Rothermel, A. ; Willbold, E. |
| Art des Eintrags: | Bibliographie |
| Titel: | Inductive effects of the retinal pigmented epithelium (RPE) on histogenesis of the avian retina as revealed by retinospheroid technology. |
| Sprache: | Englisch |
| Publikationsjahr: | 1998 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Seminars in cell & developmental biology |
| Jahrgang/Volume einer Zeitschrift: | 9 |
| (Heft-)Nummer: | 3 |
| Kurzbeschreibung (Abstract): | During eye formation, inductive phenomena occurring between retinal pigmented epithelium (RPE) and retina are not well understood. After briefly summarizing the normal development of retina and RPE, we present three-dimensional in vitro models of the chick embryonic retina which allows elucidation of RPE-retina interactions. In such retinospheroids, a complete arrangement of layers is achieved, provided that dispersed retinal cells are: (1) young enough; and (2) reaggregated on a monolayer of RPE. Thereby, the RPE extends cell proliferation, while differentiation is much delayed. These findings assign to the RPE a decisive role for the genesis and regeneration of a vertebrate retina. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie ?? fb10_zoologie ?? 10 Fachbereich Biologie > Developmental Biology and Neurogenetics |
| Hinterlegungsdatum: | 21 Nov 2011 12:48 |
| Letzte Änderung: | 05 Mär 2013 09:56 |
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