Papadopoulos, Theofilos ; Korte, Martin ; Eulenburg, Volker ; Kubota, Hisahiko ; Retiounskaia, Marina ; Harvey, Robert J. ; Harvey, Kirsten ; O'Sullivan, Gregory A. ; Laube, Bodo ; Hülsmann, Swen ; Geiger, Jörg R. P. ; Betz, Heinrich (2007)
Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin-deficient mice.
In: The EMBO journal, 26 (17)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Collybistin (Cb) is a brain-specific guanine nucleotide exchange factor that has been implicated in plasma membrane targeting of the postsynaptic scaffolding protein gephyrin found at glycinergic and GABAergic synapses. Here we show that Cb-deficient mice display a region-specific loss of postsynaptic gephyrin and GABA(A) receptor clusters in the hippocampus and the basolateral amygdala. Cb deficiency is accompanied by significant changes in hippocampal synaptic plasticity, due to reduced dendritic GABAergic inhibition. Long-term potentiation is enhanced, and long-term depression reduced, in Cb-deficient hippocampal slices. Consistent with the anatomical and electrophysiological findings, the animals show increased levels of anxiety and impaired spatial learning. Together, our data indicate that Cb is essential for gephyrin-dependent clustering of a specific set of GABA(A) receptors, but not required for glycine receptor postsynaptic localization.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2007 |
| Autor(en): | Papadopoulos, Theofilos ; Korte, Martin ; Eulenburg, Volker ; Kubota, Hisahiko ; Retiounskaia, Marina ; Harvey, Robert J. ; Harvey, Kirsten ; O'Sullivan, Gregory A. ; Laube, Bodo ; Hülsmann, Swen ; Geiger, Jörg R. P. ; Betz, Heinrich |
| Art des Eintrags: | Bibliographie |
| Titel: | Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin-deficient mice. |
| Sprache: | Englisch |
| Publikationsjahr: | 2007 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | The EMBO journal |
| Jahrgang/Volume einer Zeitschrift: | 26 |
| (Heft-)Nummer: | 17 |
| Kurzbeschreibung (Abstract): | Collybistin (Cb) is a brain-specific guanine nucleotide exchange factor that has been implicated in plasma membrane targeting of the postsynaptic scaffolding protein gephyrin found at glycinergic and GABAergic synapses. Here we show that Cb-deficient mice display a region-specific loss of postsynaptic gephyrin and GABA(A) receptor clusters in the hippocampus and the basolateral amygdala. Cb deficiency is accompanied by significant changes in hippocampal synaptic plasticity, due to reduced dendritic GABAergic inhibition. Long-term potentiation is enhanced, and long-term depression reduced, in Cb-deficient hippocampal slices. Consistent with the anatomical and electrophysiological findings, the animals show increased levels of anxiety and impaired spatial learning. Together, our data indicate that Cb is essential for gephyrin-dependent clustering of a specific set of GABA(A) receptors, but not required for glycine receptor postsynaptic localization. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > Neurophysiologie und neurosensorische Systeme ?? fb10_zoologie ?? |
| Hinterlegungsdatum: | 11 Apr 2011 09:24 |
| Letzte Änderung: | 05 Mär 2019 06:48 |
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