Krämer, J. ; Aguirre-Arteta, A. M. ; Thiel, C. ; Gross, C. M. ; Dietz, R. ; Cardoso, M. Cristina ; Leonhardt, H. (1999)
A novel isoform of the smooth muscle cell differentiation marker smoothelin.
In: Journal of molecular medicine, 77 (2)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Studies on smooth muscle cell differentiation and those on vascular development in mouse and humans have long been hampered by the lack of suitable markers. Here we describe a novel, large isoform of smoothelin, a structural protein of differentiated, contractile smooth muscle cells. The protein, which is highly conserved in mouse and humans, shows homology with other cytoskeleton-associated smooth muscle cell proteins and contains an actinin-type actin-binding domain. Northern blot analysis from various mouse organs identified short and long smoothelin mRNA forms, which exhibit distinct tissue expression patterns. The short form is highly expressed in visceral muscle tissues such as intestine and stomach and is not detectable in brain, while the long mRNA form is expressed in all vascularized organs. These results may provide new tools and approaches to study both smooth muscle cell differentiation and proliferative vascular disease.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 1999 |
| Autor(en): | Krämer, J. ; Aguirre-Arteta, A. M. ; Thiel, C. ; Gross, C. M. ; Dietz, R. ; Cardoso, M. Cristina ; Leonhardt, H. |
| Art des Eintrags: | Bibliographie |
| Titel: | A novel isoform of the smooth muscle cell differentiation marker smoothelin. |
| Sprache: | Deutsch |
| Publikationsjahr: | 1999 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Journal of molecular medicine |
| Jahrgang/Volume einer Zeitschrift: | 77 |
| (Heft-)Nummer: | 2 |
| URL / URN: | http://www.cardoso-lab.org/publications/Kraemer_1999.PDF |
| Kurzbeschreibung (Abstract): | Studies on smooth muscle cell differentiation and those on vascular development in mouse and humans have long been hampered by the lack of suitable markers. Here we describe a novel, large isoform of smoothelin, a structural protein of differentiated, contractile smooth muscle cells. The protein, which is highly conserved in mouse and humans, shows homology with other cytoskeleton-associated smooth muscle cell proteins and contains an actinin-type actin-binding domain. Northern blot analysis from various mouse organs identified short and long smoothelin mRNA forms, which exhibit distinct tissue expression patterns. The short form is highly expressed in visceral muscle tissues such as intestine and stomach and is not detectable in brain, while the long mRNA form is expressed in all vascularized organs. These results may provide new tools and approaches to study both smooth muscle cell differentiation and proliferative vascular disease. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie ?? fb10_zoologie ?? 10 Fachbereich Biologie > Cell Biology and Epigenetics |
| Hinterlegungsdatum: | 05 Mär 2010 15:52 |
| Letzte Änderung: | 06 Jul 2018 09:51 |
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