Quensel, Christina ; Krämer, Jochen ; Cardoso, M. Cristina ; Leonhardt, Heinrich (2002)
Smoothelin contains a novel actin cytoskeleton localization sequence with similarity to troponin T.
In: Journal of cellular biochemistry, 85 (2)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Smoothelin, a cytoskeletal protein, exists in a large isoform specifically expressed in vascular smooth muscle cells, and a small visceral isoform generated by a downstream transcriptional start site. Using fusions to the green fluorescent protein, we could show that both smoothelin isoforms are localized at actin containing filaments and mapped two domains that are each sufficient for localization at the actin cytoskeleton. The first domain is located in the vascular-specific, N-terminal half of smoothelin and the second in the common, C-terminal half. The second domain shares clear sequence similarity with a domain of troponin T involved in actin filament association. These results suggest that the tissue-specific expression of smoothelin isoforms might contribute to the different contractile properties of smooth muscle cells.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2002 |
| Autor(en): | Quensel, Christina ; Krämer, Jochen ; Cardoso, M. Cristina ; Leonhardt, Heinrich |
| Art des Eintrags: | Bibliographie |
| Titel: | Smoothelin contains a novel actin cytoskeleton localization sequence with similarity to troponin T. |
| Sprache: | Deutsch |
| Publikationsjahr: | 2002 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Journal of cellular biochemistry |
| Jahrgang/Volume einer Zeitschrift: | 85 |
| (Heft-)Nummer: | 2 |
| URL / URN: | http://www.cardoso-lab.org/publications/Quensel_2002.pdf |
| Kurzbeschreibung (Abstract): | Smoothelin, a cytoskeletal protein, exists in a large isoform specifically expressed in vascular smooth muscle cells, and a small visceral isoform generated by a downstream transcriptional start site. Using fusions to the green fluorescent protein, we could show that both smoothelin isoforms are localized at actin containing filaments and mapped two domains that are each sufficient for localization at the actin cytoskeleton. The first domain is located in the vascular-specific, N-terminal half of smoothelin and the second in the common, C-terminal half. The second domain shares clear sequence similarity with a domain of troponin T involved in actin filament association. These results suggest that the tissue-specific expression of smoothelin isoforms might contribute to the different contractile properties of smooth muscle cells. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie > Cell Biology and Epigenetics ?? fb10_zoologie ?? 10 Fachbereich Biologie |
| Hinterlegungsdatum: | 06 Mär 2010 07:22 |
| Letzte Änderung: | 05 Mär 2013 09:32 |
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