Cardoso, M. Cristina ; Leonhardt, Heinrich (2002)
Protein transduction: a novel tool for tissue regeneration.
In: Biological chemistry, 383 (10)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Tissue regeneration in humans is limited and excludes vitals organs like heart and brain. Transformation experiments with oncogenes like T antigen have shown that retrodifferentiation of the respective cells is possible but hard to control. To bypass the risk of cancer formation a protein therapy approach has been developed. The transient delivery of proteins rather than genes could still induce terminally-differentiated cells to reenter the cell cycle. This approach takes advantage of protein-transducing domains that mediate the transfer of cargo proteins into cells. The goal of this brief review is to outline the basics of protein transduction and to discuss potential applications for tissue regeneration.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2002 |
| Autor(en): | Cardoso, M. Cristina ; Leonhardt, Heinrich |
| Art des Eintrags: | Bibliographie |
| Titel: | Protein transduction: a novel tool for tissue regeneration. |
| Sprache: | Deutsch |
| Publikationsjahr: | 2002 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Biological chemistry |
| Jahrgang/Volume einer Zeitschrift: | 383 |
| (Heft-)Nummer: | 10 |
| URL / URN: | http://www.cardoso-lab.org/publications/Cardoso_2002.pdf |
| Kurzbeschreibung (Abstract): | Tissue regeneration in humans is limited and excludes vitals organs like heart and brain. Transformation experiments with oncogenes like T antigen have shown that retrodifferentiation of the respective cells is possible but hard to control. To bypass the risk of cancer formation a protein therapy approach has been developed. The transient delivery of proteins rather than genes could still induce terminally-differentiated cells to reenter the cell cycle. This approach takes advantage of protein-transducing domains that mediate the transfer of cargo proteins into cells. The goal of this brief review is to outline the basics of protein transduction and to discuss potential applications for tissue regeneration. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie > Cell Biology and Epigenetics ?? fb10_zoologie ?? 10 Fachbereich Biologie |
| Hinterlegungsdatum: | 06 Mär 2010 07:24 |
| Letzte Änderung: | 05 Mär 2013 09:32 |
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