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Protein transduction: a novel tool for tissue regeneration.

Cardoso, M Cristina and Leonhardt, Heinrich (2002):
Protein transduction: a novel tool for tissue regeneration.
In: Biological chemistry, pp. 1593-9, 383, (10), ISSN 1431-6730,
[Online-Edition: http://www.cardoso-lab.org/publications/Cardoso_2002.pdf],
[Article]

Abstract

Tissue regeneration in humans is limited and excludes vitals organs like heart and brain. Transformation experiments with oncogenes like T antigen have shown that retrodifferentiation of the respective cells is possible but hard to control. To bypass the risk of cancer formation a protein therapy approach has been developed. The transient delivery of proteins rather than genes could still induce terminally-differentiated cells to reenter the cell cycle. This approach takes advantage of protein-transducing domains that mediate the transfer of cargo proteins into cells. The goal of this brief review is to outline the basics of protein transduction and to discuss potential applications for tissue regeneration.

Item Type: Article
Erschienen: 2002
Creators: Cardoso, M Cristina and Leonhardt, Heinrich
Title: Protein transduction: a novel tool for tissue regeneration.
Language: German
Abstract:

Tissue regeneration in humans is limited and excludes vitals organs like heart and brain. Transformation experiments with oncogenes like T antigen have shown that retrodifferentiation of the respective cells is possible but hard to control. To bypass the risk of cancer formation a protein therapy approach has been developed. The transient delivery of proteins rather than genes could still induce terminally-differentiated cells to reenter the cell cycle. This approach takes advantage of protein-transducing domains that mediate the transfer of cargo proteins into cells. The goal of this brief review is to outline the basics of protein transduction and to discuss potential applications for tissue regeneration.

Journal or Publication Title: Biological chemistry
Volume: 383
Number: 10
Divisions: 10 Department of Biology > Cell Biology and Epigenetics
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10 Department of Biology
Date Deposited: 06 Mar 2010 07:24
Official URL: http://www.cardoso-lab.org/publications/Cardoso_2002.pdf
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