Paraoanu, Laura E. ; Steinert, G. ; Klaczinski, J. ; Becker-Roeck, Michaela ; Bytyqi, Afrim H. ; Layer, Paul G. (2006)
On functions of cholinesterases during embryonic development.
In: Journal of molecular neuroscience, 30 (1-2)
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Expression of cholinesterase (ChE) activity during phases of embryonic development is a general phenomenon in embryonic tissues. To elucidate the role(s) of ChEs during embryonic development, one line of research followed the assumption of a primitive muscarinic system involved in morphogenesis (Hohmann et al., 1995). This means that ChE functioning during development fits into the classical cholinergic neurotransmitter system: acetylcholine (ACh), as a signal, binds to ACh receptors and then is degraded by acetylcholinesterase (AChE) as the terminating enzyme. However, this is just one of the possible mechanisms. The other line of research was driven by evidence for noncholinergic functions of ChE proteins (AChE and butyrylcholinesterase [BChE]). There is accumulating data that other sites on AChE could exert nonclassical roles related to cell differentiation, neurite outgrowth, and adhesion.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2006 |
| Autor(en): | Paraoanu, Laura E. ; Steinert, G. ; Klaczinski, J. ; Becker-Roeck, Michaela ; Bytyqi, Afrim H. ; Layer, Paul G. |
| Art des Eintrags: | Bibliographie |
| Titel: | On functions of cholinesterases during embryonic development |
| Sprache: | Englisch |
| Publikationsjahr: | 2006 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Journal of molecular neuroscience |
| Jahrgang/Volume einer Zeitschrift: | 30 |
| (Heft-)Nummer: | 1-2 |
| Kurzbeschreibung (Abstract): | Expression of cholinesterase (ChE) activity during phases of embryonic development is a general phenomenon in embryonic tissues. To elucidate the role(s) of ChEs during embryonic development, one line of research followed the assumption of a primitive muscarinic system involved in morphogenesis (Hohmann et al., 1995). This means that ChE functioning during development fits into the classical cholinergic neurotransmitter system: acetylcholine (ACh), as a signal, binds to ACh receptors and then is degraded by acetylcholinesterase (AChE) as the terminating enzyme. However, this is just one of the possible mechanisms. The other line of research was driven by evidence for noncholinergic functions of ChE proteins (AChE and butyrylcholinesterase [BChE]). There is accumulating data that other sites on AChE could exert nonclassical roles related to cell differentiation, neurite outgrowth, and adhesion. |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie ?? fb10_zoologie ?? 10 Fachbereich Biologie > Developmental Biology and Neurogenetics |
| Hinterlegungsdatum: | 20 Nov 2008 08:24 |
| Letzte Änderung: | 20 Feb 2020 13:24 |
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