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FKBP Ligands—Where We Are and Where to Go?

Kolos, Jürgen M. ; Voll, Andreas M. ; Bauder, Michael ; Hausch, Felix (2018)
FKBP Ligands—Where We Are and Where to Go?
In: Frontiers in Pharmacology, 9
doi: 10.3389/fphar.2018.01425
Artikel, Bibliographie

Dies ist die neueste Version dieses Eintrags.

Kurzbeschreibung (Abstract)

In recent years, many members of the FK506-binding protein (FKBP) family were increasingly linked to various diseases. The binding domain of FKBPs differs only in a few amino acid residues, but their biological roles are versatile. High-affinity ligands with selectivity between close homologs are scarce. This review will give an overview of the most prominent ligands developed for FKBPs and highlight a perspective for future developments. More precisely, human FKBPs and correlated diseases will be discussed as well as microbial FKBPs in the context of anti-bacterial and anti-fungal therapeutics. The last section gives insights into high-affinity ligands as chemical tools and dimerizers.

Typ des Eintrags: Artikel
Erschienen: 2018
Autor(en): Kolos, Jürgen M. ; Voll, Andreas M. ; Bauder, Michael ; Hausch, Felix
Art des Eintrags: Bibliographie
Titel: FKBP Ligands—Where We Are and Where to Go?
Sprache: Englisch
Publikationsjahr: 2018
Verlag: Frontiers
Titel der Zeitschrift, Zeitung oder Schriftenreihe: Frontiers in Pharmacology
Jahrgang/Volume einer Zeitschrift: 9
DOI: 10.3389/fphar.2018.01425
URL / URN: https://doi.org/10.3389/fphar.2018.01425
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Kurzbeschreibung (Abstract):

In recent years, many members of the FK506-binding protein (FKBP) family were increasingly linked to various diseases. The binding domain of FKBPs differs only in a few amino acid residues, but their biological roles are versatile. High-affinity ligands with selectivity between close homologs are scarce. This review will give an overview of the most prominent ligands developed for FKBPs and highlight a perspective for future developments. More precisely, human FKBPs and correlated diseases will be discussed as well as microbial FKBPs in the context of anti-bacterial and anti-fungal therapeutics. The last section gives insights into high-affinity ligands as chemical tools and dimerizers.

Sachgruppe der Dewey Dezimalklassifikatin (DDC): 500 Naturwissenschaften und Mathematik > 540 Chemie
Fachbereich(e)/-gebiet(e): 07 Fachbereich Chemie
07 Fachbereich Chemie > Clemens-Schöpf-Institut > Fachgebiet Biochemie
07 Fachbereich Chemie > Clemens-Schöpf-Institut
Hinterlegungsdatum: 02 Jul 2024 23:05
Letzte Änderung: 02 Jul 2024 23:05
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