TU Darmstadt / ULB / TUbiblio

FKBP Ligands—Where We Are and Where to Go?

Kolos, Jürgen M. ; Voll, Andreas M. ; Bauder, Michael ; Hausch, Felix (2018):
FKBP Ligands—Where We Are and Where to Go?
In: Frontiers in Pharmacology, 9, Frontiers, ISSN 1663-9812,
DOI: 10.3389/fphar.2018.01425,
[Article]

Abstract

In recent years, many members of the FK506-binding protein (FKBP) family were increasingly linked to various diseases. The binding domain of FKBPs differs only in a few amino acid residues, but their biological roles are versatile. High-affinity ligands with selectivity between close homologs are scarce. This review will give an overview of the most prominent ligands developed for FKBPs and highlight a perspective for future developments. More precisely, human FKBPs and correlated diseases will be discussed as well as microbial FKBPs in the context of anti-bacterial and anti-fungal therapeutics. The last section gives insights into high-affinity ligands as chemical tools and dimerizers.

Item Type: Article
Erschienen: 2018
Creators: Kolos, Jürgen M. ; Voll, Andreas M. ; Bauder, Michael ; Hausch, Felix
Title: FKBP Ligands—Where We Are and Where to Go?
Language: English
Abstract:

In recent years, many members of the FK506-binding protein (FKBP) family were increasingly linked to various diseases. The binding domain of FKBPs differs only in a few amino acid residues, but their biological roles are versatile. High-affinity ligands with selectivity between close homologs are scarce. This review will give an overview of the most prominent ligands developed for FKBPs and highlight a perspective for future developments. More precisely, human FKBPs and correlated diseases will be discussed as well as microbial FKBPs in the context of anti-bacterial and anti-fungal therapeutics. The last section gives insights into high-affinity ligands as chemical tools and dimerizers.

Journal or Publication Title: Frontiers in Pharmacology
Journal volume: 9
Publisher: Frontiers
Divisions: 07 Department of Chemistry
07 Department of Chemistry > Fachgebiet Biochemie
Date Deposited: 24 Feb 2019 20:55
DOI: 10.3389/fphar.2018.01425
Official URL: https://doi.org/10.3389/fphar.2018.01425
URN: urn:nbn:de:tuda-tuprints-85010
Export:
Suche nach Titel in: TUfind oder in Google
Send an inquiry Send an inquiry

Options (only for editors)
Show editorial Details Show editorial Details