Kolos, Jürgen M. ; Voll, Andreas M. ; Bauder, Michael ; Hausch, Felix (2019)
FKBP Ligands—Where We Are and Where to Go?
In: Frontiers in Pharmacology, 2018, 9
doi: 10.3389/fphar.2018.01425
Artikel, Zweitveröffentlichung
Kurzbeschreibung (Abstract)
In recent years, many members of the FK506-binding protein (FKBP) family were increasingly linked to various diseases. The binding domain of FKBPs differs only in a few amino acid residues, but their biological roles are versatile. High-affinity ligands with selectivity between close homologs are scarce. This review will give an overview of the most prominent ligands developed for FKBPs and highlight a perspective for future developments. More precisely, human FKBPs and correlated diseases will be discussed as well as microbial FKBPs in the context of anti-bacterial and anti-fungal therapeutics. The last section gives insights into high-affinity ligands as chemical tools and dimerizers.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2019 |
| Autor(en): | Kolos, Jürgen M. ; Voll, Andreas M. ; Bauder, Michael ; Hausch, Felix |
| Art des Eintrags: | Zweitveröffentlichung |
| Titel: | FKBP Ligands—Where We Are and Where to Go? |
| Sprache: | Englisch |
| Publikationsjahr: | 2019 |
| Publikationsdatum der Erstveröffentlichung: | 2018 |
| Verlag: | Frontiers |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Frontiers in Pharmacology |
| Jahrgang/Volume einer Zeitschrift: | 9 |
| DOI: | 10.3389/fphar.2018.01425 |
| URL / URN: | https://doi.org/10.3389/fphar.2018.01425 |
| Herkunft: | Zweitveröffentlichung aus gefördertem Golden Open Access |
| Kurzbeschreibung (Abstract): | In recent years, many members of the FK506-binding protein (FKBP) family were increasingly linked to various diseases. The binding domain of FKBPs differs only in a few amino acid residues, but their biological roles are versatile. High-affinity ligands with selectivity between close homologs are scarce. This review will give an overview of the most prominent ligands developed for FKBPs and highlight a perspective for future developments. More precisely, human FKBPs and correlated diseases will be discussed as well as microbial FKBPs in the context of anti-bacterial and anti-fungal therapeutics. The last section gives insights into high-affinity ligands as chemical tools and dimerizers. |
| URN: | urn:nbn:de:tuda-tuprints-85010 |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 500 Naturwissenschaften und Mathematik > 540 Chemie |
| Fachbereich(e)/-gebiet(e): | 07 Fachbereich Chemie 07 Fachbereich Chemie > Clemens-Schöpf-Institut > Fachgebiet Biochemie |
| Hinterlegungsdatum: | 24 Feb 2019 20:55 |
| Letzte Änderung: | 20 Okt 2023 09:00 |
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| Suche nach Titel in: | TUfind oder in Google |
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