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Virus Irradiation and COVID-19 Disease

Durante, Marco ; Schulze, Kai ; Incerti, Sebastien ; Francis, Ziad ; Zein, Sara ; Guzmán, Carlos Alberto (2020)
Virus Irradiation and COVID-19 Disease.
In: Frontiers in Physics, 8
doi: 10.3389/fphy.2020.565861
Artikel, Bibliographie

Dies ist die neueste Version dieses Eintrags.

Kurzbeschreibung (Abstract)

Virus irradiation has been performed for many decades for basic research studies, sterilization, and vaccine development. The COVID-19 outbreak is currently causing an enormous effort worldwide for finding a vaccine against coronavirus. High doses of γ-rays can be used for the development of vaccines that exploit inactivated virus. This technique has been gradually replaced by more practical methods, in particular the use of chemicals, but irradiation remains a simple and effective method used in some cases. The technique employed for inactivating a virus has an impact on its ability to induce an adaptive immune response able to confer effective protection. We propose here that accelerated heavy ions can be used to inactivate SARS-CoV-2 viruses with small damage to the spike proteins of the envelope and can then provide an intact virion for vaccine development.

Typ des Eintrags: Artikel
Erschienen: 2020
Autor(en): Durante, Marco ; Schulze, Kai ; Incerti, Sebastien ; Francis, Ziad ; Zein, Sara ; Guzmán, Carlos Alberto
Art des Eintrags: Bibliographie
Titel: Virus Irradiation and COVID-19 Disease
Sprache: Englisch
Publikationsjahr: 20 Oktober 2020
Ort: Lausanne
Verlag: Frontiers Media S.A.
Titel der Zeitschrift, Zeitung oder Schriftenreihe: Frontiers in Physics
Jahrgang/Volume einer Zeitschrift: 8
Kollation: 7 Seiten
DOI: 10.3389/fphy.2020.565861
Zugehörige Links:
Kurzbeschreibung (Abstract):

Virus irradiation has been performed for many decades for basic research studies, sterilization, and vaccine development. The COVID-19 outbreak is currently causing an enormous effort worldwide for finding a vaccine against coronavirus. High doses of γ-rays can be used for the development of vaccines that exploit inactivated virus. This technique has been gradually replaced by more practical methods, in particular the use of chemicals, but irradiation remains a simple and effective method used in some cases. The technique employed for inactivating a virus has an impact on its ability to induce an adaptive immune response able to confer effective protection. We propose here that accelerated heavy ions can be used to inactivate SARS-CoV-2 viruses with small damage to the spike proteins of the envelope and can then provide an intact virion for vaccine development.

Freie Schlagworte: COVID-19, SARS-CoV-2, virus, gamma rays, heavy ions
ID-Nummer: Artikel-ID: 565861
Zusätzliche Informationen:

This article is part of the Research Topic: Applied Nuclear Physics at Accelerators

Specialty section: This article was submitted to Medical Physics and Imaging, a section of the journal Frontiers in Physics

Sachgruppe der Dewey Dezimalklassifikatin (DDC): 500 Naturwissenschaften und Mathematik > 530 Physik
500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie
600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin, Gesundheit
Fachbereich(e)/-gebiet(e): 05 Fachbereich Physik
05 Fachbereich Physik > Institut für Physik Kondensierter Materie (IPKM)
Hinterlegungsdatum: 19 Mär 2024 10:15
Letzte Änderung: 19 Mär 2024 10:15
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