Durante, Marco ; Schulze, Kai ; Incerti, Sebastien ; Francis, Ziad ; Zein, Sara ; Guzmán, Carlos Alberto (2024)
Virus Irradiation and COVID-19 Disease.
In: Frontiers in Physics, 2020, 8
doi: 10.26083/tuprints-00016724
Artikel, Zweitveröffentlichung, Verlagsversion
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Kurzbeschreibung (Abstract)
Virus irradiation has been performed for many decades for basic research studies, sterilization, and vaccine development. The COVID-19 outbreak is currently causing an enormous effort worldwide for finding a vaccine against coronavirus. High doses of γ-rays can be used for the development of vaccines that exploit inactivated virus. This technique has been gradually replaced by more practical methods, in particular the use of chemicals, but irradiation remains a simple and effective method used in some cases. The technique employed for inactivating a virus has an impact on its ability to induce an adaptive immune response able to confer effective protection. We propose here that accelerated heavy ions can be used to inactivate SARS-CoV-2 viruses with small damage to the spike proteins of the envelope and can then provide an intact virion for vaccine development.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2024 |
| Autor(en): | Durante, Marco ; Schulze, Kai ; Incerti, Sebastien ; Francis, Ziad ; Zein, Sara ; Guzmán, Carlos Alberto |
| Art des Eintrags: | Zweitveröffentlichung |
| Titel: | Virus Irradiation and COVID-19 Disease |
| Sprache: | Englisch |
| Publikationsjahr: | 12 März 2024 |
| Ort: | Darmstadt |
| Publikationsdatum der Erstveröffentlichung: | 20 Oktober 2020 |
| Ort der Erstveröffentlichung: | Lausanne |
| Verlag: | Frontiers Media S.A. |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Frontiers in Physics |
| Jahrgang/Volume einer Zeitschrift: | 8 |
| Kollation: | 7 Seiten |
| DOI: | 10.26083/tuprints-00016724 |
| URL / URN: | https://tuprints.ulb.tu-darmstadt.de/16724 |
| Zugehörige Links: | |
| Herkunft: | Zweitveröffentlichung DeepGreen |
| Kurzbeschreibung (Abstract): | Virus irradiation has been performed for many decades for basic research studies, sterilization, and vaccine development. The COVID-19 outbreak is currently causing an enormous effort worldwide for finding a vaccine against coronavirus. High doses of γ-rays can be used for the development of vaccines that exploit inactivated virus. This technique has been gradually replaced by more practical methods, in particular the use of chemicals, but irradiation remains a simple and effective method used in some cases. The technique employed for inactivating a virus has an impact on its ability to induce an adaptive immune response able to confer effective protection. We propose here that accelerated heavy ions can be used to inactivate SARS-CoV-2 viruses with small damage to the spike proteins of the envelope and can then provide an intact virion for vaccine development. |
| Freie Schlagworte: | COVID-19, SARS-CoV-2, virus, gamma rays, heavy ions |
| ID-Nummer: | Artikel-ID: 565861 |
| Status: | Verlagsversion |
| URN: | urn:nbn:de:tuda-tuprints-167245 |
| Zusätzliche Informationen: | This article is part of the Research Topic: Applied Nuclear Physics at Accelerators Specialty section: This article was submitted to Medical Physics and Imaging, a section of the journal Frontiers in Physics |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 500 Naturwissenschaften und Mathematik > 530 Physik 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin, Gesundheit |
| Fachbereich(e)/-gebiet(e): | 05 Fachbereich Physik 05 Fachbereich Physik > Institut für Physik Kondensierter Materie (IPKM) |
| Hinterlegungsdatum: | 12 Mär 2024 12:53 |
| Letzte Änderung: | 19 Mär 2024 10:14 |
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| Zugehörige Links: | |
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| Suche nach Titel in: | TUfind oder in Google |
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- Virus Irradiation and COVID-19 Disease. (deposited 12 Mär 2024 12:53) [Gegenwärtig angezeigt]
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